CDP-4-dehydro-6-deoxyglucose reductase

CDP-4-dehydro-6-deoxyglucose reductase
Identifiers
EC no.	1.17.1.1
CAS no.	37256-87-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

CDP-4-dehydro-6-deoxyglucose reductase (EC 1.17.1.1) is an enzyme that catalyzes the chemical reaction

CDP-4-dehydro-3,6-dideoxy-D-glucose + NAD(P)⁺ + H₂O ${\displaystyle \rightleftharpoons }$ CDP-4-dehydro-6-deoxy-D-glucose + NAD(P)H + H⁺

The 4 substrates of this enzyme are CDP-4-dehydro-3,6-dideoxy-D-glucose, nicotinamide adenine dinucleotide ion, nicotinamide adenine dinucleotide phosphate ion, and water, whereas its 4 products are CDP-4-dehydro-6-deoxy-D-glucose, nicotinamide adenine dinucleotide, nicotinamide adenine dinucleotide phosphate, and hydrogen ion.

This enzyme belongs to the family of oxidoreductases, specifically those acting on CH or CH₂ groups with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is CDP-4-dehydro-3,6-dideoxy-D-glucose:NAD(P)⁺ 3-oxidoreductase. Other names in common use include CDP-4-keto-6-deoxyglucose reductase, cytidine diphospho-4-keto-6-deoxy-D-glucose reductase, cytidine diphosphate 4-keto-6-deoxy-D-glucose-3-dehydrogenase, CDP-4-keto-deoxy-glucose reductase, CDP-4-keto-6-deoxy-D-glucose-3-dehydrogenase system, and NAD(P)H:CDP-4-keto-6-deoxy-D-glucose oxidoreductase. This enzyme participates in starch and sucrose metabolism.

References

• Pape H, Strominger JL (1969). "Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexoses. V. Partial purification of the two protein components required for introduction of the 3-deoxy group". J. Biol. Chem. 244 (13): 3598–604. doi: 10.1016/S0021-9258(18)83411-1 . PMID   4389672.
• Rubenstein PA, Strominger JL (1974). "Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexoses. 8. Mechanistic roles of enzyme E-1 and pyridoxamine 5'-phosphate in the formation of cytidine diphosphate-4-keto-3,6-dideoxy-D-glucose from cytidine diphosphate-4-keto-6-deoxy-D-glucose". J. Biol. Chem. 249 (12): 3776–81. doi: 10.1016/S0021-9258(19)42541-6 . PMID   4152100.
• Liu HW, Thorson JS (1994). "Pathways and mechanisms in the biogenesis of novel deoxysugars by bacteria". Annu. Rev. Microbiol. 48 (1): 223–56. doi:10.1146/annurev.mi.48.100194.001255. PMID   7826006.