Carnosine synthase

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carnosine synthase
Identifiers
EC no. 6.3.2.11
CAS no. 9023-61-4
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MetaCyc metabolic pathway
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Carnosine synthase (EC 6.3.2.11) is an enzyme that catalyzes the chemical reaction

ATP + L-histidine + beta-alanine ADP + phosphate + carnosine

The 3 substrates of this enzyme are ATP, L-histidine, and beta-alanine, whereas its 3 products are ADP (previously thought to form AMP [1] ), diphosphate, and carnosine.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is 'L-histidine:beta-alanine ligase (AMP-forming)' (incorrect on AMP-forming [2] ). Other names in common use include 'carnosine synthetase', 'carnosine-anserine synthetase', 'homocarnosine synthetase', and 'carnosine-homocarnosine synthetase'.

Gene

The gene encoding this enzyme has been identified by Jakub Drozak and coworkers in 2010. [3] The gene encoding the Carnosine synthase is ATPGD1, a member of the “ATP-grasp family” of ligases. Because of its involvement in the formation of carnosine, this gene is now also named 'CARNS1'. [4]

Related Research Articles

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References

  1. "ENZYME - 6.3.2.11 Carnosine synthase".
  2. "Chemistry - Queen Mary University of London".
  3. Drozak J, Veiga-da-Cunha M, Vertommen D, Stroobant V, Van Schaftingen E (Mar 2010). "Molecular identification of carnosine synthase as ATP-grasp domain-containing protein 1 (ATPGD1)". Journal of Biological Chemistry. 285 (13): 9346–56. doi: 10.1074/jbc.M109.095505 . PMC   2843183 . PMID   20097752.
  4. "Carnosine Synthase 1".