Cob(II)yrinic acid a,c-diamide reductase

cob(II)yrinic acid a,c-diamide reductase
Identifiers
EC no.	1.16.8.1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a cob(II)yrinic acid a,c-diamide reductase (EC 1.16.8.1) is an enzyme that catalyzes the chemical reaction

2 cob(I)yrinic acid a,c-diamide + FMN + 3 H⁺${\displaystyle \rightleftharpoons }$ 2 cob(II)yrinic acid a,c-diamide + FMNH₂

The three substrates of this enzyme are cob(I)yrinic acid a,c-diamide, flavin mononucleotide, and H⁺; its two products are cob(II)yrinic acid a,c-diamide and FMNH2.

Classification

This enzyme belongs to the family of oxidoreductases, specifically those oxidizing metal ion with a flavin as acceptor.

Nomenclature

The systematic name of this enzyme class is cob(I)yrinic acid-a,c-diamide:FMN oxidoreductase. This enzyme is also called CobR and cob(II)yrinic acid-a,c-diamide:FMN oxidoreductase (incorrect).

Biological role

This enzyme is part of the biosynthetic pathway to cobalamin (vitamin B₁₂) in bacteria.

See also

• Cobalamin biosynthesis

References

• Blanche F, Maton L, Debussche L, Thibaut D (1992). "Purification and characterization of Cob(II)yrinic acid a,c-diamide reductase from Pseudomonas denitrificans". J. Bacteriol. 174 (22): 7452–4. doi:10.1128/jb.174.22.7452-7454.1992. PMC   207442 . PMID   1429467.
• Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC (2002). "The biosynthesis of adenosylcobalamin (vitamin B₁₂)". Nat. Prod. Rep. 19 (4): 390–412. doi:10.1039/b108967f. PMID   12195810.