Dana–Farber Cancer Institute

Last updated
Dana-Farber Cancer Institute
Dana-Farber Cancer Institute logo.svg
Dana-Farber Cancer Institute
Geography
Location450 Brookline Avenue, Boston, Massachusetts, United States
Coordinates 42°20′15″N71°06′30″W / 42.337637°N 71.108195°W / 42.337637; -71.108195
Organization
Care system Private
Funding Non-profit hospital
Type Specialist
Affiliated university Harvard Medical School, Harvard University
Services
Standards NCI-designated Cancer Center
Speciality Oncology, Teaching hospital
Helipad Yes
History
Opened1947
Links
Website www.dana-farber.org
Lists Hospitals in Massachusetts

Dana-Farber Cancer Institute is a comprehensive cancer treatment and research institution in Boston, Massachusetts. Dana-Farber is the founding member of the Dana-Farber/Harvard Cancer Center, Harvard's Comprehensive Cancer Center designated by the National Cancer Institute, and one of the 15 clinical affiliates and research institutes of Harvard Medical School.

Contents

As of 2023, Dana-Farber is ranked the #4 cancer hospital in the world. [1] Two Nobel laureates in Physiology or Medicine are among its past and present faculty. Dana-Farber's research discoveries include the development of the highly successful Gleevec to treat chronic myeloid leukemia.

Overview

Dana–Farber employs more than 4,855 full-time and part-time workers, 529 faculty, and has annual gross revenues of about $1,733,386,000. [2] All faculty and postdoctoral research fellows at Dana–Farber hold the equivalent academic positions concurrently at Harvard University. There are more than 523,425 adult and pediatric patient visits (combined exam and office visits) a year, and it is involved in more than 1,000 clinical trials. It is internationally known for its research and clinical excellence. Expertscape ranks its programs in aplastic anemia [3] and multiple myeloma [4] as best in the world. It has been also ranked overall the fifth best cancer hospital in the United States by U.S. News & World Report . [5] Dana–Farber is a member of the Multiple Myeloma Research Consortium.

In addition to being a principal teaching affiliate of Harvard Medical School, Dana–Farber is also a federally designated Center for AIDS Research, and a founding member of the Dana–Farber/Harvard Cancer Center (DF/HCC), [6] a federally designated Comprehensive Cancer Center. Providing advanced training in cancer treatment and research for an international faculty, Dana–Farber conducts community-based programs in cancer prevention, detection, and control in New England, and maintains joint programs with other Boston institutions, including St. Elizabeth's Medical Center, Brigham and Women's Hospital, Boston Children's Hospital, and Massachusetts General Hospital.

Dana–Farber is supported by the National Cancer Institute, the National Institute of Allergy and Infectious Diseases, and private foundations and individuals contributions. The Jimmy Fund is the principal charity of the Institute named for one of its child patients. The Boston Red Sox adopted the Jimmy Fund as its official charity in 1953 and continues to prominently sponsor the charity.[ citation needed ]

Laurie Glimcher is President/CEO of Dana–Farber Cancer Institute/Jimmy Fund. [7] In 2015, Forbes listed the charity as the 37th biggest in the U.S. [8]

History

In August 2018, Dana–Farber Cancer Institute launched a Chinese language section to the hospital website. The new pages are intended to reach Chinese-speaking people both in the United States and abroad who are seeking cancer-related information. The hospital also has a Spanish language site. [9]

In February 2020, Dana–Farber Cancer Institute inked an investing collaboration deal with MPM Capital. The deal combines MPM's venture capital investment fundraising with Dana–Farber's fundraising for cancer research. [10]

In September 2023, Dana-Farber Cancer Institute announced a new partnership with Beth Israel Deaconess Medical Center and plans to build a new standalone hospital focused on treating adult cancer patients. This includes a departure from their current home and longtime affiliation with Brigham and Women’s Hospital, which had been recognized among U.S. News & World Report's top cancer care facilities for 23 consecutive years. [11]

Breakthroughs

Dana–Farber has a long history of breakthrough discoveries in cancer care and research.

Academic Fraud

In 2024, it came to light that work by several of Dana Farber's executives was fraudulent. The findings, compiled by a British molecular biologist Sholto David, revealed deliberate fabrications by Dana-Farber’s chief executive, Dr. Laurie Glimcher, and its chief operating officer, Dr. William Hahn. More than 58 studies, many of them influential, were affected. The retractions were part of a larger trend of accountability for instances of scientific misconduct. [13] [14] [15] [16]

Patient care

Dana–Farber/St. Elizabeth's Cancer Center (DF/SEMC) and Dana–Farber/Brigham and Women's Cancer Center (DF/BWCC) are collaborations between Dana–Farber Cancer Institute, St. Elizabeth's Medical Center, and Brigham and Women's Hospital to care for adults with cancer. Dana–Farber provides outpatient services, while inpatient care is provided by St. Elizabeth's Medical Center and Brigham and Women's Hospital. DF/SEMC and DF/BWCC care for adult patients in more than a dozen specialized treatment centers.[ citation needed ]

Dana–Farber/Boston Children's Cancer and Blood Disorders Center is a more than 70-year-old partnership between Boston Children's Hospital and Dana–Farber Cancer Institute that delivers comprehensive care to children with and survivors of all types of childhood cancers.

They also work with several other local New England organizations that share a similar vision, such as Take a Swing at Cancer, [17] Angel's Hope, Childhood Cancer Lifeline of New Hampshire and Andrew's Helpful Hands.

Dana–Farber/Harvard Cancer Center

The Dana–Farber/Harvard Cancer Center is the largest National Cancer Institute (NCI) designated Comprehensive Cancer Center in the nation. Founded in 1997, DF/HCC is an inter-institutional research enterprise that unites all of the cancer research efforts of the Harvard affiliated community. The primary goal of the Cancer Center is to encourage and promote collaborative interactions and translational research that will lead to new approaches to cancer prevention, diagnosis, and treatment.[ citation needed ]

DF/HCC is one of just 39 NCI designated Comprehensive Cancer Centers. Its members hail from the following institutions: Beth Israel Deaconess Medical Center, Brigham and Women’s Hospital, Boston Children's Hospital, Dana–Farber Cancer Institute, Harvard Medical School, Harvard School of Public Health, Massachusetts General Hospital, and St. Elizabeth's Medical Center. [18]

Related Research Articles

<span class="mw-page-title-main">Massachusetts General Hospital</span> Hospital in Massachusetts, United States

Massachusetts General Hospital is the original and largest teaching hospital of Harvard Medical School, Harvard University located in the West End neighborhood of Boston, Massachusetts. Massachusetts General Hospital houses the world's largest hospital-based research program, the Mass General Research Institute, with an annual research budget of more than $1.2 billion in 2021. It is the third-oldest general hospital in the United States with a patient capacity of 999 beds. Along with Brigham and Women's Hospital, Mass General is a founding member of Mass General Brigham, formerly known as Partners HealthCare, the largest healthcare provider in Massachusetts.

<span class="mw-page-title-main">Brigham and Women's Hospital</span> Hospital in Massachusetts, United States

Brigham and Women's Hospital (BWH) is the second largest teaching hospital of Harvard Medical School and the largest hospital in the Longwood Medical Area in Boston, Massachusetts. Along with Massachusetts General Hospital, it is one of the two founding members of Mass General Brigham, the largest healthcare provider in Massachusetts. Robert Higgins, MD, MSHA serves as the hospital's current president.

<span class="mw-page-title-main">Frederick Pei Li</span> Chinese-American physician (1940–2015)

Frederick Pei Li was a Chinese-American physician. He is most famous for his discovery, together with his colleague Joseph Fraumeni, of Li–Fraumeni syndrome, which is caused by germline mutations of the p53 tumor suppressor gene and genetically predisposes families to high rates of cancer.

<span class="mw-page-title-main">Sidney Farber</span> American pediatric pathologist regarded as the father of chemotherapy

Sidney Farber was an American pediatric pathologist. He is regarded as the father of modern chemotherapy for his work using folic acid antagonists to combat leukemia, which led to the development of other chemotherapeutic agents against other malignancies. Farber was also active in cancer research advocacy and fundraising, most notably through his establishment of the Jimmy Fund, a foundation dedicated to pediatric research in childhood cancers. The Dana–Farber Cancer Institute is named after him.

The Israel Cancer Research Fund (ICRF) is a fund for cancer research. The ICRF was founded in 1975 by a group of American and Canadian physicians, scientists, and laypeople who sought to prevent the permanent loss of Israel's cancer researchers to foreign universities due to the lack of funding in Israel for newly minted Ph. D.s, post-doctoral fellows and accomplished young scientists (a phenomenon known to many as Israel's "brain drain"). With chapters in New York, Los Angeles, Chicago, Toronto, Montreal, and Jerusalem, ICRF annually sponsors a grant review process conducted by an expert panel of U.S. and Canadian scientists and oncologists and modeled on the NIH grant-making process.

<span class="mw-page-title-main">George Q. Daley</span> Medical academic

George Quentin Daley is the Dean of the Faculty of Medicine, Caroline Shields Walker Professor of Medicine, and Professor of Biological Chemistry and Molecular Pharmacology at Harvard Medical School. He was formerly the Robert A. Stranahan Professor of Pediatrics at Harvard Medical School, Director of the Stem Cell Transplantation Program at Boston Children's Hospital, and an investigator of the Howard Hughes Medical Institute, Associate Director of Children's Stem Cell Program, a member of the Executive Committee of the Harvard Stem Cell Institute. He is a past president of the International Society for Stem Cell Research (2007–2008).

Laurie Hollis Glimcher is an American physician-scientist who was appointed president and CEO of Dana–Farber Cancer Institute in October 2016. She was elected a Member of the American Philosophical Society in 2019.

<span class="mw-page-title-main">Szent-Györgyi Prize for Progress in Cancer Research</span>

The Szent-Györgyi Prize for Progress in Cancer Research, established by National Foundation for Cancer Research (NFCR) and named in honor of Albert Szent-Györgyi, Nobel laureate and co-founder of NFCR, has been awarded annually since 2006 to outstanding researchers whose scientific achievements have expanded the understanding of cancer and whose vision has moved cancer research in new directions. The Szent-Györgyi Prize honors researchers whose discoveries have made possible new approaches to preventing, diagnosing and/or treating cancer. The Prize recipient is honored at a formal dinner and award ceremony and receives a $25,000 cash prize. In addition, the recipient leads the next "Szent-Györgyi Prize Committee" as honorary chairman.

Eric P. Winer is a medical oncologist and clinical researcher specializing in breast cancer. He is director of Yale Cancer Center and president and physician-in-chief of Smilow Cancer Hospital Yale New Haven Health System, effective February 1, 2022. He also is Deputy Dean for Cancer Research at Yale School of Medicine. From 1997 to 2021, he was the Chief of the Breast Oncology Program at Dana–Farber Cancer Institute in Boston, Massachusetts. Beginning in 2013, he held a range of institutional roles at Dana-Farber, including Chief of Clinical Development, the Thompson Chair in Breast Cancer Research and Director of the Dana-Farber/Harvard SPORE in Breast Cancer. He also served as a Professor of Medicine at Harvard Medical School. He was president of the American Society of Clinical Oncology (ASCO) 2022-2023 and became Chair of the Board in mid-June 2023. His career has been focused on breast cancer treatment and research.

Edward J. Benz Jr. is the former president of Dana–Farber Cancer Institute in Boston, Massachusetts., and the Richard and Susan Smith Professor of Medicine as well as a professor of genetics at Harvard Medical School.

Carolyn Kaelin was an American cancer surgeon. She worked at the Dana–Farber Cancer Institute and founded the Comprehensive Breast Health Center at Brigham and Women’s Hospital in 1995.

Nathanael S. Gray is an American chemist. He serves as Krishnan-Shah Family Professor of chemical and systems biology at Stanford University and director of cancer therapeutics programme at Stanford University School of Medicine. Previously he was a Nancy Lurie Marks Professor of biological chemistry and molecular pharmacology at Harvard Medical School and professor of cancer biology at Dana–Farber Cancer Institute. Gray is also co-founder, science advisory board member (SAB) and equity holder in C4 Therapeutics, Gatekeeper, Syros, Petra, B2S, Aduro, Jengu, Allorion, Inception Therapeutics, and Soltego. C4 Therapeutics, which offered IPO in 2020, was founded based on the ground-breaking research of Jay Bradner, current president of Novartis Institutes for BioMedical Research (NIBR), and of Nathanael S. Gray, while he was professor at Harvard Medical School. Before moving to Stanford University, Nathanael S. Gray created Center for Protein Degradation at Harvard Medical School with $80 million agreement with Deerfield Management venture capital firm. In 2020, Gray Lab permanently moved to Stanford University, that was stated by Stuart Schreiber, co-founder of Broad Institute as "Stanford's huge gain".

Mary-Ellen Taplin, is a research oncologist at Dana Farber Cancer Institute and Brigham and Women's Hospital in Harvard's Longwood Medical and Academic Area.

<span class="mw-page-title-main">Jay Loeffler</span> American physician

Jay Steven Loeffler was an American physician at Massachusetts General Hospital where he served as Chair of the Department of Radiation Oncology since 2000. He was the Herman and Joan Suit Professor of Radiation Oncology and Professor of Neurosurgery at Harvard Medical School.

Matthew Kulke is an American cancer researcher. He is the Chief of Hematology/Oncology, co-director of the BU/BMC Cancer Center and "Zoltan Kohn Professor" at the Boston University School of Medicine. His work has shed light on the molecular characteristics of neuroendocrine tumors and has led to the development of multiple new treatments for this condition. His research studies led to the development and approval of telotristat ethyl, a tryptophan hydroxylase inhibitor, for the treatment of patients with carcinoid syndrome. He has also contributed to early and late stage clinical trials of temozolomide, sunitinib, everolimus, and peptide receptor radiotherapy for neuroendocrine tumors.

Catherine J. Wu is an American physician-scientist who studies oncology. She is a Professor of Medicine and Chief of Division of Stem Cell Transplantation and Cellular Therapies at the Dana–Farber Cancer Institute. Her research focuses on longitudinal studies of patients with chronic lymphocytic leukemia (CLL).

Scott Allen Armstrong is an American pediatric oncologist and cancer biologist focused on chromatin-based control of gene expression in cancer and therapeutic discovery. Armstrong and his team were the first to isolate rare leukemia stem cells in a mouse model of leukemia.

Daphne Adele Haas-Kogan is an American radiation oncologist. She is the Willem and Corrie Hees Family Professor of Radiation Oncology at Harvard Medical School.

Nancy Lin is an American oncologist who works at the Dana-Farber Cancer Institute and is an Associate Professor of Medicine at Harvard Medical School. Her research considers new diagnostic strategies and treatment pathways for HER2 positive breast cancer.

James D. Griffin is an American physician-scientist. He is currently Professor of Medicine at Harvard Medical School, Chair of Medical Oncology at Dana–Farber Cancer Institute, and Director of Medical Oncology at Brigham and Women's Hospital. He is considered an expert in medical oncology and is widely recognized for his research in the clinical and biologic aspects of hemotologic malignancies.

References

  1. Newsweek (2022-09-14). "World's Best Specialized Hospitals 2023". Newsweek. Retrieved 2023-01-02.
  2. "Dana-Farber Cancer Institute 2019 Facts" (PDF). Archived from the original (PDF) on 2015-07-17. Retrieved 2015-07-16.
  3. "Expertscape: Aplastic Anemia, December 2013". expertscape.com. December 2013. Retrieved 2015-08-17.
  4. "Expertscape: Multiple Myeloma, February 2014". expertscape.com. February 2014. Retrieved 2014-02-18.
  5. "Best Hospitals Specialty Search: Cancer". U.S News & World Report . Archived from the original on 2012-04-06. Retrieved 2020-04-19.
  6. "Dana-Farber/Harvard Cancer Center" . Retrieved 2007-10-15.
  7. "Laurie H. Glimcher, MD". dana-farber.org. Archived from the original on 14 January 2017. Retrieved 14 April 2018.
  8. "Dana-Farber Cancer Institute on the Forbes The 100 Largest U.S. Charities List". Forbes. Retrieved 14 April 2018.
  9. Berlin, Ellen (2018-08-16). "Dana-Farber targets Chinese-speaking patients with new website". Boston Business Journal . Retrieved 2018-08-17.
  10. "Dana-Farber Cancer Institute and MPM Capital Announce $100 Million Cancer Fund". BioSpace. Retrieved 2020-02-28.
  11. Sacchetti, Sharman (2023-09-15). "New hospital proposed as Boston-based medical giants change partnerships". WCVB. Retrieved 2024-01-06.
  12. "William G. Kaelin Jr – Facts – 2019". NobelPrize.org. Retrieved 6 July 2022.
  13. https://www.nytimes.com/2024/01/22/health/dana-farber-cancer-studies-retractions.html
  14. https://www.bostonherald.com/2024/01/23/dana-farber-cancer-institute-to-retract-6-studies-correct-31-after-data-forgery-allegations/
  15. https://www.cbsnews.com/boston/news/dana-farber-cancer-institute-boston-harvard-data-manipulation-claims/
  16. https://apnews.com/article/danafarber-cancer-scandal-harvard-sleuth-science-389dc2464f25bca736183607bc57415c
  17. "tasc14". tasc14. Retrieved 14 April 2018.
  18. "NCI Cancer Centers Program". Archived from the original on 2008-05-05. Retrieved 2007-06-07.