Esafoxolaner/eprinomectin/praziquantel

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Esafoxolaner/eprinomectin/praziquantel
Combination of
Esafoxolaner aryl isoxazoline
Eprinomectin avermectin anthelmintic
Praziquantel pyrazinoisoquinoline anthelmintic
Clinical data
Trade names Nexgard Combo
Routes of
administration
Topical
ATC code
Legal status
Legal status

Esafoxolaner/eprinomectin/praziquantel, sold under the brand name Nexgard Combo, is a fixed-dose combination medication used for the treatment and control of flea infestations, ticks, ear mites, and infections caused by tapeworms and Toxocara cati . [3] It is also used for the prevention of heartworm disease Dirofilaria immitis . It contains esafoxolaner, an aryl isoxazoline; eprinomectin, an avermectin anthelmintic; and praziquantel, a pyrazinoisoquinoline anthelmintic. [3]

Medical uses

In the United States, esafoxolaner/eprinomectin/praziquantel is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of roundworm (fourth stage larval and adult Toxocara cati), hookworm (fourth stage larval and adult Ancylostoma tubaeforme ; adult Ancylostoma braziliense ), and tapeworm ( Dipylidium caninum ) infections. [4] [5] It kills adult fleas ( Ctenocephalides felis ) and is indicated for the treatment and prevention of flea infestations and the treatment and control of Ixodes scapularis (black-legged tick) and Amblyomma americanum (lone star tick) infestations for one month in cats and kittens eight weeks of age and older, and weighing 1.8 pounds (0.82 kg) or greater. [4] [5]

Related Research Articles

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References

  1. "Nexgard Combo Product information". Health Canada . 5 January 2022. Retrieved 14 April 2024.
  2. "Health product highlights 2021: Annexes of products approved in 2021". Health Canada . 3 August 2022. Retrieved 25 March 2024.
  3. 1 2 3 "Nexgard Combo- esafoxolaner, eprinomectin, and praziquantel solution". DailyMed. 7 March 2024. Retrieved 14 April 2024.
  4. 1 2 "NexGard Combo 141-570". U.S. Food and Drug Administration. Retrieved 14 April 2024.PD-icon.svg This article incorporates text from this source, which is in the public domain .
  5. 1 2 https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/13855