Dichlorophen

Dichlorophen
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	P02DX02 ( WHO );
Identifiers
	IUPAC name 4-Chloro-2-[(5-chloro-2-hydroxyphenyl)methyl]phenol;
CAS Number	97-23-4 ;
PubChem CID	3037 ;
ChemSpider	2929 ;
UNII	T1J0JOU64O ;
KEGG	C14292 ;
ChEMBL	ChEMBL33845 ;
CompTox Dashboard (EPA)	DTXSID6021824 ;
ECHA InfoCard	100.002.335
Chemical and physical data
Formula	C13H10Cl2O2
Molar mass	269.12 g·mol−1
3D model (JSmol)	Interactive image ;
Density	1.5 g/cm3 g/cm3
Melting point	177.5 °C (351.5 °F)
Solubility in water	0.003 g/100 mL mg/mL (20 °C)
	SMILES C1=CC(=C(C=C1Cl)CC2=C(C=CC(=C2)Cl)O)O;
	InChI InChI=1S/C13H10Cl2O2/c14-10-1-3-12(16)8(6-10)5-9-7-11(15)2-4-13(9)17/h1-4,6-7,16-17H,5H2 ; Key:MDNWOSOZYLHTCG-UHFFFAOYSA-N ;
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Last updated October 02, 2025

Dichlorophen is an anticestodal agent, fungicide, germicide, and antimicrobial agent.^[2] It is used in combination with toluene for the removal of parasites such as ascarids, hookworms, and tapeworms from dogs and cats.^[3] In 2025, dichlorophen was reported to function as a tubulin binding mitotic inhibitor.^[4]

Safety and regulation

The LD₅₀ (oral, mouse) is 3300 mg/kg.^[5]

References

↑ Lide DR (1998). Handbook of Chemistry and Physics (87 ed.). Boca Raton, Florida: CRC Press. pp. 8–118. ISBN 0-8493-0594-2.
↑ Milne, G.W.A. (Ed.). (2005). Gardner's commercially important chemicals: Synonyms, trade names, and properties. Hoboken, N.J.: Wiley-Interscience. Google Books
↑ "Code of Federal Regulations", Code of Federal Regulations, Title 21, Volume 6, U.S. Government Printing Office, 2005-04-01, retrieved 2009-05-01
↑ Baksheeva VE, La Rocca R, Allegro D, Derviaux C, Pasquier E, Roche P, Morelli X, Devred F, Golovin AV, Tsvetkov PO (2025). "NanoDSF Screening for Anti-tubulin Agents Uncovers New Structure–Activity Insights". Journal of Medicinal Chemistry. doi:10.1021/acs.jmedchem.5c01008.
↑ Fiege H, Voges HW, Hamamoto T, Umemura S, Iwata T, Miki H, Fujita Y, Buysch HJ, Garbe D, Paulus W (2007). "Phenol Derivatives". Ullmann's Encyclopedia of Industrial Chemistry . Weinheim: Wiley-VCH. doi:10.1002/14356007.a19_313. ISBN 978-3-527-30673-2.

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[hand2-1] Lide DR (1998). Handbook of Chemistry and Physics (87 ed.). Boca Raton, Florida: CRC Press. pp. 8–118. ISBN 0-8493-0594-2.

[gard-2] Milne, G.W.A. (Ed.). (2005). Gardner's commercially important chemicals: Synonyms, trade names, and properties. Hoboken, N.J.: Wiley-Interscience. Google Books

[cfr-3] "Code of Federal Regulations", Code of Federal Regulations, Title 21, Volume 6, U.S. Government Printing Office, 2005-04-01, retrieved 2009-05-01

[4] Baksheeva VE, La Rocca R, Allegro D, Derviaux C, Pasquier E, Roche P, Morelli X, Devred F, Golovin AV, Tsvetkov PO (2025). "NanoDSF Screening for Anti-tubulin Agents Uncovers New Structure–Activity Insights". Journal of Medicinal Chemistry. doi:10.1021/acs.jmedchem.5c01008.

[a-5] Fiege H, Voges HW, Hamamoto T, Umemura S, Iwata T, Miki H, Fujita Y, Buysch HJ, Garbe D, Paulus W (2007). "Phenol Derivatives". Ullmann's Encyclopedia of Industrial Chemistry . Weinheim: Wiley-VCH. doi:10.1002/14356007.a19_313. ISBN 978-3-527-30673-2.

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