Doramectin

Last updated
Doramectin
Doramectin.svg
Doramectin2.png
Clinical data
Trade names Dectomax, others
Other names
  • 25-cyclohexylavermectin B1,
  • 25-cyclohexyl-25-de(l-methylpropyl)avermectin B1a,
  • 25-cyclohexyl-5-O-demethyl-25-de(l-methylpropyl)avermectin A1a
AHFS/Drugs.com International Drug Names
License data
Routes of
administration
Subcutaneous, intramuscular, topical
ATCvet code
Legal status
Legal status
Identifiers
  • (1'R,2S,4'S,5S,6R,8'R,10'E,12'R,13'S,14'E,20'R,21'R,24'S)-6-cyclohexyl-21',24'-dihydroxy-12'-{[(2R,4S,5S,6S)-5-{[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy}-4-methoxy-6-methyloxan-2-yl]oxy}-5,11',13',22'-tetramethyl-5,6-dihydro-3',7',19'-trioxaspiro[pyran-2,6'-tetracyclo[15.6.1.14,8.020,24]pentacosane]-10',14',16',22'-tetraen-2'-one
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard 100.123.125 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C50H74O14
Molar mass 899.128 g·mol−1
  • InChI=1S/C50H74O14/c1-27-13-12-16-34-26-57-47-42(51)30(4)21-37(50(34,47)54)48(53)60-36-22-35(63-49(25-36)20-19-29(3)45(64-49)33-14-10-9-11-15-33)18-17-28(2)44(27)61-41-24-39(56-8)46(32(6)59-41)62-40-23-38(55-7)43(52)31(5)58-40/h12-13,16-17,19-21,27,29,31-33,35-47,51-52,54H,9-11,14-15,18,22-26H2,1-8H3/b13-12+,28-17+,34-16+/t27-,29-,31-,32-,35+,36-,37-,38-,39-,40-,41-,42+,43-,44-,45-,46-,47+,49+,50+/m0/s1 Yes check.svgY
  • Key:QLFZZSKTJWDQOS-YDBLARSUSA-N Yes check.svgY
   (verify)

Doramectin, sold under the brand name Dectomax among others, is a veterinary medication approved by the US Food and Drug Administration (FDA) for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice, and mange mites in cattle. [1] [2] It is available as a generic medication. [3] It is available as a combination with levamisole under the brand name Valcor. [4]

Contents

It is used for the treatment and control of internal parasitosis (gastrointestinal and pulmonary nematodes), ticks and mange (and other ectoparasites). Doramectin is a derivative of avermectin. Similarly to other drugs of this family, it is produced by fermentation by selected strains of Streptomyces avermitilis followed by chemical modification. [1] [2] [5] Its spectrum includes: Haemonchus, Ostertagia, Trichostrongylus, Cooperia , and Oesophagostomum species and Dictyocaulus viviparus , Dermatobia hominis, Boophilus microplus , and Psoroptes bovis , among many other internal and external parasites. It is available as an injection and as a topical solution. [1] [2]

Society and culture

In November 2024, the FDA approved doramectin (brand name Doracide) for the treatment and control of gastrointestinal roundworms, lungworms, eyeworms, grubs, biting and sucking lice, horn flies, and mange mites in cattle. [6] [7]

Brand names

Doramectin is marketed under the brand name Doramec L.A. for cattle, sheep, and swine.[ citation needed ]

Doramectin is available for horses as an oral, flavored, bioadhesive gel under the name Doraquest L.A. Oral Gel. It can be used to control and treat internal parasites as roundworms, lungworms and some external parasites.[ citation needed ]

References

  1. 1 2 3 4 "Dectomax- doramectin injection, solution". DailyMed. 13 September 2022. Retrieved 25 January 2023.
  2. 1 2 3 4 "Dectomax Pour-On- doramectin solution". DailyMed. 5 August 2022. Retrieved 25 January 2023.
  3. 1 2 "FDA Approves First Generic Doramectin for Use in Cattle". U.S. Food and Drug Administration (FDA). 11 January 2023. Archived from the original on January 17, 2023. Retrieved 25 January 2023.
  4. "Animal Drugs @ FDA". animaldrugsatfda.fda.gov. Retrieved 25 January 2023.
  5. Goudie AC, Evans NA, Gration KA, Bishop BF, Gibson SP, Holdom KS, et al. (July 1993). "Doramectin--a potent novel endectocide". Veterinary Parasitology. 49 (1): 5–15. doi:10.1016/0304-4017(93)90218-c. PMID   8236738.
  6. "Recent Animal Drug Approvals". U.S. Food and Drug Administration (FDA). 2 December 2024. Retrieved 21 December 2024.PD-icon.svg This article incorporates text from this source, which is in the public domain .
  7. fda.gov