Ricobendazole

Ricobendazole
Clinical data
Trade names	Rycoben
Identifiers
	IUPAC name methyl [6-(propylsulfinyl)-1H-benzimidazol-2-yl]carbamate;
CAS Number	54029-12-8 ;
PubChem CID	83969 ;
DrugBank	DB13871 ;
ChemSpider	75767 ;
UNII	J39B52TV34 ;
KEGG	D07106 ;
ChEBI	CHEBI:16959 ;
ChEMBL	ChEMBL1665 ;
CompTox Dashboard (EPA)	DTXSID4057768 ;
ECHA InfoCard	100.157.043
Chemical and physical data
Formula	C12H15N3O3S
Molar mass	281.33 g·mol−1
3D model (JSmol)	Interactive image ;
	SMILES CCCS(=O)c1ccc2[nH]c(NC(=O)OC)nc2c1;
	InChI InChI=1S/C12H15N3O3S/c1-3-6-19(17)8-4-5-9-10(7-8)14-11(13-9)15-12(16)18-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16) ; Key:VXTGHWHFYNYFFV-UHFFFAOYSA-N;

Last updated August 21, 2025

Ricobendazole, also known as albendazole S-oxide, is a broad-spectrum benzimidazole anthelmintic. Its main use is for protecting livestock against nematode parasites.^[1] Ricobendazole is the active sulfoxide metabolite of albendazole.^[2]

Like mebendazole, ricobendazole inhibits tubulin polymerization.

References

↑ Junquera P (26 July 2015). "Ricobendazole = Albendazole Sulfoxide for Veterinary Use on Cattle, Sheep, Goats, Pig Poultry, Dogs and Cats against roundworms, tapeworms and liver flukes". Parasitipedia. Archived from the original on 4 March 2016. Retrieved 21 October 2015.
↑ Stuchlíková LR, Matoušková P, Vokřál I, Lamka J, Szotáková B, Sečkařová A, et al. (April 2018). "Metabolism of albendazole, ricobendazole and flubendazole in Haemonchus contortus adults: Sex differences, resistance-related differences and the identification of new metabolites". International Journal for Parasitology. Drugs and Drug Resistance. 8 (1): 50–58. doi:10.1016/j.ijpddr.2018.01.005. PMC 6114105 . PMID 29414106.

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[parasitipedia-ricobendazole-1] Junquera P (26 July 2015). "Ricobendazole = Albendazole Sulfoxide for Veterinary Use on Cattle, Sheep, Goats, Pig Poultry, Dogs and Cats against roundworms, tapeworms and liver flukes". Parasitipedia. Archived from the original on 4 March 2016. Retrieved 21 October 2015.

[Stuchlikova_2018-2] Stuchlíková LR, Matoušková P, Vokřál I, Lamka J, Szotáková B, Sečkařová A, et al. (April 2018). "Metabolism of albendazole, ricobendazole and flubendazole in Haemonchus contortus adults: Sex differences, resistance-related differences and the identification of new metabolites". International Journal for Parasitology. Drugs and Drug Resistance. 8 (1): 50–58. doi:10.1016/j.ijpddr.2018.01.005. PMC 6114105 . PMID 29414106.

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