Oxfendazole

Last updated
Oxfendazole
Oxfendazole.svg
Clinical data
AHFS/Drugs.com International Drug Names
ATCvet code
Identifiers
  • Methyl N-[6-(benzenesulfinyl)-1H-1,3-benzodiazol-2-yl]carbamate
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard 100.053.358 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C15H13N3O3S
Molar mass 315.35 g·mol−1

Oxfendazole is a broad spectrum benzimidazole anthelmintic. Its main use is for protecting livestock against roundworm, strongyles and pinworms. [1] [2] Oxfendazole is the sulfoxide metabolite of fenbendazole.

Contents

Oxfendazole is an anthelmintic (wormer) compound used in veterinary practice. It comes under the chemical class of the benzimidazoles. This drug is barely used in horses, [3] goats, sheep, and cattle. It is very scarcely applied on dogs and cats. The drug for livestock is majorly available in the form of pills, tablets, drenches, bolus, etc. They are meant for oral consumption. Several drenches are allowed for intraruminal injection in some of the countries. Few countries also prefer injectables and pour-ons. For pet dogs, the drug is available in the form of drenches.

Efficacy

Both oxfendazole and fenbendazole are efficacious against gastrointestinal lungworms and roundworms of livestock, adults, and L4-larvae of the significant species for example, of the genera Bunostomum , Haemonchus , Ostertagia , Oesophagostomum , Nematodirus , Teladorsagia , Cooperia , Trichostrongylus , Dictyocaulus , Trichuris , etc., including against arrested larvae of some of the species. [4] [5] [6] They are even highly efficient against majority of the tapeworms commonly found in livestock. [7] [8] [9] This drug works effectively against the main parasitic roundworms and tapeworms of dogs and cats. [10] [11]

The drug offers a small residual effect in ruminants unless and otherwise it is delivered by using a slow-release device. This essentially means that on a single administration it will help in killing the parasites which are present in the host during the time of treatment and also prevent against re-infestations for some more days but not weeks or months. The residual effect is comparatively shorter in non-ruminants. The drug is non-effective against flukes and external parasites at therapeutic dose.

Adverse Effects

Since the toxicity of oxfendazole is quite low, it is generally well tolerated by most species. However, high oral doses can causes intoxication resulting in loss of appetite, diarrhea, fever, cramps, nausea, vomit and convulsions, hepatic and epicardial hemorrhage, allergic reactions etc. Due to lack of research, it is not suggested to use oxfendazole in pregnant mares and bitches. It is also not recommended to use oxfendazole tablets to treat dogs or cats. [12] A registered veterinarian must authorize the use of oxfendazole.in any species.

Society and culture

Brand names

Oxfendazole is sold under brand names of Synanthic (Suspension), [13] Benzelmin (Paste), [14] Anthelcide EQ(Paste).

Related Research Articles

<span class="mw-page-title-main">Trichuriasis</span> Infection by Trichuris trichiura (whipworm)

Trichuriasis, also known as whipworm infection, is an infection by the parasitic worm Trichuris trichiura (whipworm). If infection is only with a few worms, there are often no symptoms. In those who are infected with many worms, there may be abdominal pain, fatigue and diarrhea. The diarrhea sometimes contains blood. Infections in children may cause poor intellectual and physical development. Low red blood cell levels may occur due to loss of blood.

<span class="mw-page-title-main">Praziquantel</span> Medication

Praziquantel (PZQ), sold under the brandname Biltricide among others, is a medication used to treat a number of types of parasitic worm infections in mammals, birds, amphibians, reptiles, and fish. In humans specifically, it is used to treat schistosomiasis, clonorchiasis, opisthorchiasis, tapeworm infections, cysticercosis, echinococcosis, paragonimiasis, fasciolopsiasis, and fasciolosis. It should not be used for worm infections of the eye. It is taken by mouth.

<span class="mw-page-title-main">Albendazole</span> Chemical compound

Albendazole is a broad-spectrum antihelmintic and antiprotozoal agent of the benzimidazole type. It is used for the treatment of a variety of intestinal parasite infections, including ascariasis, pinworm infection, hookworm infection, trichuriasis, strongyloidiasis, taeniasis, clonorchiasis, opisthorchiasis, cutaneous larva migrans, giardiasis, and gnathostomiasis, among other diseases.

<span class="mw-page-title-main">Oxibendazole</span> Chemical compound

Oxibendazole is a benzimidazole drug that is used to protect against roundworms, strongyles, threadworms, pinworms and lungworm infestations in horses and some domestic pets. It is usually white to yellowish in appearance, and may take the form of a powder, tablet or paste.

<span class="mw-page-title-main">Tiabendazole</span> Chemical compound

Tiabendazole, also known as thiabendazole or TBZ and the trade names Mintezol, Tresaderm, and Arbotect, is a preservative, an antifungal agent, and an antiparasitic agent.

<i>Ascaridia galli</i> Species of roundworm

Ascaridia galli is a parasitic roundworm belonging to the phylum Nematoda. Nematodes of the genus Ascaridia are essentially intestinal parasites of birds. A. galli is the most prevalent and pathogenic species, especially in domestic fowl, Gallus domesticus. It causes ascaridiasis, a disease of poultry due to heavy worm infection, particularly in chickens and turkeys. It inhabits the small intestine, and can be occasionally seen in commercial eggs.

<span class="mw-page-title-main">Moxidectin</span> Chemical compound

Moxidectin is an anthelmintic drug used in animals to prevent or control parasitic worms (helminths), such as heartworm and intestinal worms, in dogs, cats, horses, cattle and sheep. Moxidectin kills some of the most common internal and external parasites by selectively binding to a parasite's glutamate-gated chloride ion channels. These channels are vital to the function of invertebrate nerve and muscle cells; when moxidectin binds to the channels, it disrupts neurotransmission, resulting in paralysis and death of the parasite.

<i>Dictyocaulus</i> Genus of nematode parasites of the bronchial tree of horses, sheep, goats, deer, and cattle

Dictyocaulus is a genus of nematode parasites of the bronchial tree of horses, sheep, goats, deer, and cattle. Dictyocaulus arnfieldi is the lungworm of horses, and Dictyocaulus viviparus is the lungworm affecting ruminants.

<span class="mw-page-title-main">Fenbendazole</span> Chemical compound

Fenbendazole is a broad spectrum benzimidazole anthelmintic used against gastrointestinal parasites including: giardia, roundworms, hookworms, whipworms, the tapeworm genus Taenia, pinworms, aelurostrongylus, paragonimiasis, strongyles, and strongyloides that can be administered to sheep, cattle, horses, fish, dogs, cats, rabbits, most reptiles, freshwater shrimp tanks as planaria and hydra treatments, as well as seals.

Muelleries capillaris, also known as the hair or goat lungworm, is one of the most economically important nematodes of small ruminants. Although normally non-pathogenic in sheep, the parasite causes a disease condition called muelleriosis in goats. Sheep and goats commonly become infected after accidentally ingesting M. capillaris infected snails or slugs, and the parasite produces eggs in the lungs of its host, causing life-threatening bronchopneumonia in serious cases.

<i>Toxocara cati</i> Species of worm

Toxocara cati, also known as the feline roundworm, is a parasite of cats and other felids. It is one of the most common nematodes of cats, infecting both wild and domestic felids worldwide. Adult worms are localised in the gut of the host. In adult cats, the infection – which is called toxocariasis – is usually asymptomatic. However, massive infection in juvenile cats can be fatal.

<span class="mw-page-title-main">Deworming</span> Use of anthelmintic drugs

Deworming is the giving of an anthelmintic drug to a human or animals to rid them of helminths parasites, such as roundworm, flukes and tapeworm. Purge dewormers for use in livestock can be formulated as a feed supplement that is eaten, a paste or gel that is deposited at the back of the animal's mouth, a liquid drench given orally, an injectable, or as a pour-on which can be applied to the animal's topline. In dogs and cats, purge dewormers come in many forms including a granular form to be added to food, pill form, chew tablets, and liquid suspensions.

<span class="mw-page-title-main">Anthelmintic</span> Antiparasitic drugs that expel parasitic worms (helminths) from the body

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. They may also be called vermifuges or vermicides. Anthelmintics are used to treat people who are infected by helminths, a condition called helminthiasis. These drugs are also used to treat infected animals.

<i>Teladorsagia circumcincta</i> Species of roundworm

Teladorsagia circumcincta is a nematode that is one of the most important parasites of sheep and goats. It was previously known as Ostertagia circumcincta and is colloquially known as the brown stomach worm. It is common in cool, temperate areas, such as south-eastern and south-western Australia and the United Kingdom. There is considerable variation among lambs and kids in susceptibility to infection. Much of the variation is genetic and influences the immune response. The parasite induces a type I hypersensitivity response which is responsible for the relative protein deficiency which is characteristic of severely infected animals. There are mechanistic mathematical models which can predict the course of infection. There are a variety of ways to control the infection and a combination of control measures is likely to provide the most effective and sustainable control.

<i>Cooperia oncophora</i> Species of roundworm

Cooperia oncophora is one of the most common intestinal parasitic nematodes in cattle in temperate regions. Infections with C. oncophora may result in mild clinical symptoms, but can lead to weight loss and damage of the small intestine, especially when co-infections with other nematodes such as O. ostertagi occur. Infections are usually treated with broad-spectrum anthelmintics such as benzimidazole, but resistance to these drugs has developed in the last decades and is now very common. C. oncophora has a direct life cycle. Infective larvae are ingested by the host. The larvae grow to adults, which reproduce in the small intestines. Eggs are shed onto the pasture with the faeces, which leads to new infections. Co-infections with other gastro-intestinal nematodes such as O. ostertagi and H. contortus are common.

Ostertagia ostertagi, commonly known as the medium stomach worm or brown stomach worm, is a parasitic nematode of cattle. O. ostertagi can also be found to a lesser extent in sheep, goats, wild ruminants, and horses. It causes ostertagiosis, which is potentially fatal in cattle. It is found worldwide and is economically important to cattle industries, particularly those found in temperate climates.

<i>Cooperia</i> (nematode) Genus of roundworms

Cooperia is a genus of nematode from the Cooperiidae family that is one of the most common intestinal parasitic nematodes in cattle in temperate regions. Infections with Cooperia may result in mild clinical symptoms, but can lead to weight loss and damage of the small intestine, especially when co-infections with other nematodes such as Ostertagia ostertagi occur. Infections are usually treated with broad-spectrum anthelmintics such as benzimidazole, but resistance to these drugs has developed in the last decades and is now very common. Cooperia has a direct life cycle. Infective larvae are ingested by the host. The larvae grow to adults, which reproduce in the small intestines. Eggs are shed onto the pasture with the faeces, which leads to new infections. Co-infections with other gastro-intestinal nematodes such as O. ostertagi and Haemonchus contortus are common.

<span class="mw-page-title-main">Cattle drenching</span> Administration of anti-parasite drugs to cattle

Cattle drenching is the process of administering chemical solutions (anthelmintics) to cattle or Bos taurus with the purpose of protecting livestock from various parasites including worms, fluke, cattle ticks, lice and flies. Parasites hinder the production of cattle through living off their host and carrying diseases that can be transmitted to cattle. Cattle drenches can be applied through a solution poured on the back, throat or an injection. Cattle drenches are predominately necessary for young cattle with weaker immune systems that are susceptible to parasite infestation. Drenching is a common method for controlling parasites in the meat and dairy industries. Drenching cattle improves the health, condition and fertility of cattle leading to increased calving rates, weight gain, hide condition and milk production.

<span class="mw-page-title-main">Cat worm infections</span> Worm infections in cats

Cat worm infections, the infection of cats (Felidae) with parasitic worms, occur frequently. Most worm species occur worldwide in both domestic and other cats, but there are regional, species and lifestyle differences in the frequency of infestation. According to the classification of the corresponding parasites in the zoological system, infections can be divided into those caused by nematode and flatworms - in the case of the latter, mainly cestoda and trematoda - while other strains are of no veterinary significance. While threadworms usually do not require an intermediate host for their reproduction, the development cycle of flatworms always proceeds via alternate hosts.

References

  1. "Oxfendazole".
  2. Gonzalez AE, Codd EE, Horton J, Garcia HH, Gilman RH (January 2019). "Oxfendazole: a promising agent for the treatment and control of helminth infections in humans". Expert Review of Anti-infective Therapy. 17 (1): 51–56. doi:10.1080/14787210.2018.1555241. PMC   6376865 . PMID   30501436.
  3. Duncan JL, Reid JF (October 1978). "An evaluation of the efficacy of oxfendazole against the common nematode parasites of the horse". The Veterinary Record. 103 (15): 332–334. doi:10.1136/vr.103.15.332. PMID   364817.
  4. Jabbar A, Iqbal MZ, Ashraf M, Durrani AZ, Sajjad H, Wana MN, et al. (February 2022). "Effects of Ferula asafetida, closantel, albendazole, oxfendazole, and ivermectin against Haemonchus contortus in goats and sheep". Tropical Animal Health and Production. 54 (2): 107. doi:10.1007/s11250-022-03111-z. PMID   35187616.
  5. Williams JC, DeRosa A, Nakamura Y, Loyacano AF (December 1997). "Comparative efficacy of ivermectin pour-on, albendazole, oxfendazole and fenbendazole against Ostertagia ostertagi inhibited larvae, other gastrointestinal nematodes and lungworm of cattle". Veterinary Parasitology. 73 (1–2): 73–82. doi:10.1016/S0304-4017(97)00066-6. PMID   9477494.
  6. Downey NE (October 1976). "Evaluation of oxfendazole against natural infections of gastro-intestinal nematodes and lung-worms in calves". The Veterinary Record. 99 (14): 267–270. doi:10.1136/vr.99.14.267. PMID   136085. S2CID   29572443.
  7. Kipp K, Cummings DB, Goehl D, Wade HH, Davidson JM, Renter D, et al. (July 2023). "Evaluation of a refugia-based strategy for gastrointestinal nematodes on weight gain and fecal egg counts in naturally infected stocker calves administered combination anthelmintics". Veterinary Parasitology. 319: 109955. doi: 10.1016/j.vetpar.2023.109955 . PMID   37201354.
  8. Nielsen MK, Gee EK, Hansen A, Waghorn T, Bell J, Leathwick DM (September 2021). "Monitoring equine ascarid and cyathostomin parasites: Evaluating health parameters under different treatment regimens". Equine Veterinary Journal. 53 (5): 902–910. doi:10.1111/evj.13374. PMID   33119179. S2CID   226045264.
  9. Kabululu ML, Ngowi HA, Mlangwa JE, Mkupasi EM, Braae UC, Colston A, et al. (October 2020). "TSOL18 vaccine and oxfendazole for control of Taenia solium cysticercosis in pigs: A field trial in endemic areas of Tanzania". PLoS Neglected Tropical Diseases. 14 (10): e0008785. doi: 10.1371/journal.pntd.0008785 . PMC   7588121 . PMID   33052939.
  10. Gemmell MA, Johnstone PD, Oudemans G (May 1979). "The effect of oxfendazole on Echinococcus granulosus and Taenia hydatigena infections in dogs". Research in Veterinary Science. 26 (3): 389–390. doi:10.1016/S0034-5288(18)32902-3. PMID   515529.
  11. Stoye M (August 1992). "[Biology, pathogenicity, diagnosis and control of Ancylostoma caninum]". DTW. Deutsche Tierarztliche Wochenschrift. 99 (8): 315–321. PMID   1425324.
  12. "OXFENDAZOLE TOXICITY, POISONING, INTOXICATION, OVERDOSE, ANTIDOTE: SAFETY SUMMARY for VETERINARY use on DOGS, CATS, CATTLE, SHEEP, GOATS, SWINE, HORSES and POULTRY". parasitipedia.net. Retrieved 2024-02-21.
  13. "Synanthic® (oxfendazole oral suspension) Bovine Dewormer Suspension, 22.5%". dailymed.nlm.nih.gov. Retrieved 2024-02-21.
  14. "BENZELMIN WORMER Paste for HORSES - JUROX - oxfendazole, benzimidazole". parasitipedia.net. Retrieved 2024-02-21.