Glutathione peroxidase 7

GPX7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2P31
Identifiers
Aliases	GPX7 , CL683, GPX6, GPx-7, GSHPx-7, NPGPx, glutathione peroxidase 7
External IDs	OMIM: 615784; MGI: 1914555; HomoloGene: 128491; GeneCards: GPX7; OMA:GPX7 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p32.3 Start 52,602,371 bp [1] End 52,609,051 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 C7 Start 108,257,587 bp [2] End 108,264,158 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone cartilage tissue ganglionic eminence periodontal fiber gallbladder granulocyte right lobe of thyroid gland left lobe of thyroid gland anterior pituitary left uterine tube Top expressed in external naris calvaria dermis intervertebral disc efferent ductule cervical vertebral column external carotid artery fossa endocardial cushion thoracic vertebral column More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity glutathione peroxidase activity catalase activity protein binding peroxidase activity Cellular component extracellular region endoplasmic reticulum lumen endoplasmic reticulum Biological process response to oxidative stress cellular oxidant detoxification cellular response to oxidative stress Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2882 67305 Ensembl ENSG00000116157 ENSMUSG00000028597 UniProt Q96SL4 Q99LJ6 RefSeq (mRNA) NM_015696 NM_024198 RefSeq (protein) NP_056511 NP_077160 Location (UCSC) Chr 1: 52.6 – 52.61 Mb Chr 4: 108.26 – 108.26 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Glutathione peroxidase 7 is an enzyme that in humans is encoded by the GPX7 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000116157 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028597 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Utomo A, Jiang X, Furuta S, Yun J, Levin DS, Wang YC, Desai KV, Green JE, Chen PL, Lee WH (Oct 2004). "Identification of a novel putative non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase (NPGPx) essential for alleviating oxidative stress generated from polyunsaturated fatty acids in breast cancer cells". J Biol Chem. 279 (42): 43522–9. doi: 10.1074/jbc.M407141200 . PMID   15294905.
6. "Entrez Gene: GPX7 glutathione peroxidase 7".

Further reading

• Opalenik SR, Ding Q, Mallery SR, Thompson JA (1998). "Glutathione depletion associated with the HIV-1 TAT protein mediates the extracellular appearance of acidic fibroblast growth factor". Arch. Biochem. Biophys. 351 (1): 17–26. doi:10.1006/abbi.1997.0566. PMID   9501919.
• Choi J, Liu RM, Kundu RK, et al. (2000). "Molecular mechanism of decreased glutathione content in human immunodeficiency virus type 1 Tat-transgenic mice". J. Biol. Chem. 275 (5): 3693–8. doi: 10.1074/jbc.275.5.3693 . PMID   10652368.
• Richard MJ, Guiraud P, Didier C, et al. (2001). "Human immunodeficiency virus type 1 Tat protein impairs selenoglutathione peroxidase expression and activity by a mechanism independent of cellular selenium uptake: consequences on cellular resistance to UV-A radiation". Arch. Biochem. Biophys. 386 (2): 213–20. doi:10.1006/abbi.2000.2197. PMID   11368344.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Price TO, Ercal N, Nakaoke R, Banks WA (2005). "HIV-1 viral proteins gp120 and Tat induce oxidative stress in brain endothelial cells". Brain Res. 1045 (1–2): 57–63. doi:10.1016/j.brainres.2005.03.031. PMID   15910762. S2CID   7362454.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569. S2CID   13709685.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Glutathione peroxidase 7