Glutathione peroxidase 8

GPX8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3CYN, 3KIJ
Identifiers
Aliases	GPX8 , EPLA847, GPx-8, GSHPx-8, UNQ847, glutathione peroxidase 8 (putative)
External IDs	OMIM: 617172; MGI: 1916840; HomoloGene: 88454; GeneCards: GPX8; OMA:GPX8 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	55,167,297 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	113,182,944 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; tibia; ; germinal epithelium; ; placenta; ; smooth muscle tissue; ; Achilles tendon; ; parietal pleura; ; gonad; ; synovial membrane; ; corpus epididymis;
	Top expressed in
	calvaria; ; umbilical cord; ; efferent ductule; ; Epithelium of choroid plexus; ; vestibular sensory epithelium; ; decidua; ; interventricular septum; ; uterus; ; intercostal muscle; ; cervix;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity ; glutathione peroxidase activity ; peroxidase activity ;
Cellular component	integral component of membrane ; endoplasmic reticulum lumen ; membrane ;
Biological process	response to oxidative stress ; cellular oxidant detoxification ; cellular response to oxidative stress ;
	Sources:Amigo / QuickGO
Orthologs
	493869
	69590
	ENSG00000164294
	ENSMUSG00000021760
	Q8TED1
	Q9D7B7
	NM_001008397 ; NM_001306197 ; NM_001306198 ; NM_001306201
	NM_027127
	NP_001008398 ; NP_001293126 ; NP_001293127 ; NP_001293130
	NP_081403
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated July 18, 2025

Glutathione peroxidase 8 (GPx-8) is an enzyme that in humans is encoded by the GPX8 gene.^[5]^[6] GPx-8 is a member of the glutathione peroxidase family.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000164294 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021760 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: glutathione peroxidase 8 (putative)".
↑ Toppo S, Vanin S, Bosello V, Tosatto SC (September 2008). "Evolutionary and structural insights into the multifaceted glutathione peroxidase (Gpx) superfamily". Antioxid. Redox Signal. 10 (9): 1501–14. doi:10.1089/ars.2008.2057. PMID 18498225.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Glutathione Peroxidase 8 (GPX8)

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000164294 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021760 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: glutathione peroxidase 8 (putative)".

[pmid18498225-6] Toppo S, Vanin S, Bosello V, Tosatto SC (September 2008). "Evolutionary and structural insights into the multifaceted glutathione peroxidase (Gpx) superfamily". Antioxid. Redox Signal. 10 (9): 1501–14. doi:10.1089/ars.2008.2057. PMID 18498225.

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v t e Oxidoreductases: peroxidases (EC 1.11)
1.11.1.1-14	NADH peroxidase NADPH peroxidase Fatty-acid peroxidase Catalase Cytochrome c peroxidase Eosinophil peroxidase Glutathione peroxidase GPX 1 2 3 4 5 6 7 8 Horseradish peroxidase Lactoperoxidase Myeloperoxidase Thyroid peroxidase Deiodinase Iodothyronine deiodinase Iodotyrosine deiodinase
1.11.1.15 (peroxiredoxin)	1 2 3 4 5 6

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)