IQCB1

IQCB1
Identifiers
Aliases	IQCB1 , NPHP5, PIQ, SLSN5, IQ motif containing B1
External IDs	OMIM: 609237 MGI: 2443764 HomoloGene: 8766 GeneCards: IQCB1
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q13.33|3q21.1 Start 121,769,761 bp [1] End 121,835,079 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16|16 B3 Start 36,648,747 bp [2] End 36,693,083 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte monocyte body of pancreas Achilles tendon rectum bronchial epithelial cell secondary oocyte right uterine tube ganglionic eminence lymph node Top expressed in hand spermatocyte neural tube secondary oocyte superior frontal gyrus medial ganglionic eminence spermatid seminiferous tubule abdominal wall mirror More reference expression data BioGPS More reference expression data
Gene ontology Molecular function enzyme binding protein binding calmodulin binding Cellular component cytoplasm microtubule organizing center cytosol centrosome photoreceptor outer segment extracellular exosome cytoskeleton photoreceptor connecting cilium centriole nucleoplasm microtubule cytoskeleton intercellular bridge mitotic spindle Biological process photoreceptor cell maintenance maintenance of animal organ identity cell projection organization cilium assembly ciliary basal body-plasma membrane docking Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9657 320299 Ensembl ENSG00000173226 ENSMUSG00000022837 UniProt Q15051 Q8BP00 RefSeq (mRNA) NM_001023570 NM_001023571 NM_001319107 NM_014642 NM_177128 RefSeq (protein) NP_001018864 NP_001018865 NP_001306036 NP_796102 Location (UCSC) Chr 3: 121.77 – 121.84 Mb Chr 16: 36.65 – 36.69 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

IQ calmodulin-binding motif-containing protein 1 is a protein that in humans is encoded by the IQCB1 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000173226 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022837 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Otto EA, Loeys B, Khanna H, Hellemans J, Sudbrak R, Fan S, Muerb U, O'Toole JF, Helou J, Attanasio M, Utsch B, Sayer JA, Lillo C, Jimeno D, Coucke P, De Paepe A, Reinhardt R, Klages S, Tsuda M, Kawakami I, Kusakabe T, Omran H, Imm A, Tippens M, Raymond PA, Hill J, Beales P, He S, Kispert A, Margolis B, Williams DS, Swaroop A, Hildebrandt F (Feb 2005). "Nephrocystin-5, a ciliary IQ domain protein, is mutated in Senior-Loken syndrome and interacts with RPGR and calmodulin". Nat Genet. 37 (3): 282–8. doi:10.1038/ng1520. PMID   15723066. S2CID   4972004.
6. "Entrez Gene: IQCB1 IQ motif containing B1".

Further reading

• Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi: 10.1093/dnares/1.1.27 . PMID   7584026.
• Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi: 10.1093/dnares/1.1.47 . PMID   7584028.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Mollet G, Salomon R, Gribouval O, et al. (2002). "The gene mutated in juvenile nephronophthisis type 4 encodes a novel protein that interacts with nephrocystin". Nat. Genet. 32 (2): 300–5. doi:10.1038/ng996. PMID   12244321. S2CID   24216974.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Mollet G, Silbermann F, Delous M, et al. (2005). "Characterization of the nephrocystin/nephrocystin-4 complex and subcellular localization of nephrocystin-4 to primary cilia and centrosomes". Hum. Mol. Genet. 14 (5): 645–56. doi: 10.1093/hmg/ddi061 . PMID   15661758.
• le Maire A, Weber T, Saunier S, et al. (2006). "Solution NMR structure of the SH3 domain of human nephrocystin and analysis of a mutation-causing juvenile nephronophthisis". Proteins. 59 (2): 347–55. doi:10.1002/prot.20344. PMID   15723349. S2CID   37333782.
• Luo X, He Q, Huang Y, Sheikh MS (2006). "Cloning and characterization of a p53 and DNA damage down-regulated gene PIQ that codes for a novel calmodulin-binding IQ motif protein and is up-regulated in gastrointestinal cancers". Cancer Res. 65 (23): 10725–33. doi: 10.1158/0008-5472.CAN-05-1132 . PMID   16322217.