NEK8

NEK8
Identifiers
Aliases	NEK8 , JCK, NEK12A, NPHP9, RHPD2, NIMA related kinase 8
External IDs	OMIM: 609799 MGI: 1890646 HomoloGene: 84442 GeneCards: NEK8
Gene location (Human)
Chr.	Chromosome 17 (human)
End	28,743,455 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	78,067,501 bp
RNA expression pattern
	Top expressed in
	left lobe of thyroid gland; ; right lobe of thyroid gland; ; right uterine tube; ; lymph node; ; monocyte; ; visceral pleura; ; body of pancreas; ; spleen; ; right lobe of liver; ; secondary oocyte;
	Top expressed in
	saccule; ; spermatocyte; ; proximal tubule; ; otic placode; ; lip; ; spermatid; ; yolk sac; ; morula; ; thymus; ; blastocyst;
	More reference expression data
	n/a
Gene ontology
Molecular function	kinase activity ; transferase activity ; nucleotide binding ; protein kinase activity ; protein binding ; ATP binding ; metal ion binding ; protein serine/threonine kinase activity ;
Cellular component	cytoplasm ; ciliary base ; cell projection ; cytoskeleton ; ciliary inversin compartment ; cilium ;
Biological process	animal organ morphogenesis ; heart development ; regulation of hippo signaling ; determination of left/right symmetry ; phosphorylation ; protein phosphorylation ; cilium assembly ;
	Sources:Amigo / QuickGO
Orthologs
	284086
	140859
	ENSG00000160602
	ENSMUSG00000017405
	Q86SG6
	Q91ZR4
	NM_178170
	NM_080849
	NP_835464
	NP_543125
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 14, 2022

Serine/threonine-protein kinase Nek8, also known as never in mitosis A-related kinase 8, is an enzyme that in humans is encoded by the NEK8 gene.^[5]^[6]

Function

Nek8 is a member of the serine/threonine-specific protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans . The encoded protein may play a role in cell cycle progression from G2 to M phase.^[5]

Clinical significance

Mutations in the NEK8 gene associated with nephronophthisis.^[7]^[8]

Related Research Articles

Serine/threonine-protein kinase Nek2 is an enzyme that in humans is encoded by the NEK2 gene.

Serine/threonine-protein kinase Nek6 is an enzyme that in humans is encoded by the NEK6 gene.

Serine/threonine-protein kinase D2 or PKD2 is an enzyme that in humans is encoded by the PRKD2 gene.

Serine/threonine-protein kinase OSR1 is an enzyme that in humans is encoded by the OXSR1 gene.

Serine/threonine-protein kinase 38 is an enzyme that in humans is encoded by the STK38 gene.

Mitogen-activated protein kinase kinase kinase kinase 5 is an enzyme that in humans is encoded by the MAP4K5 gene.

Dual specificity protein kinase CLK3 is an enzyme that in humans is encoded by the CLK3 gene. The CLK3 gene encodes a serine/threonine type protein kinase with a non-conserved N-terminal domain. A long and short isoform result from alternative splicing and coexist in different tissues. Isoform phclk3/152 lacks the kinase domain.

Serine/threonine-protein kinase PCTAIRE-3 is an enzyme that in humans is encoded by the PCTK3 gene.

Serine/threonine-protein kinase Nek9 is an enzyme that in humans is encoded by the NEK9 gene.

Centrosome-associated protein CEP250 is a protein that in humans is encoded by the CEP250 gene. This gene encodes a core centrosomal protein required for centriole-centriole cohesion during interphase of the cell cycle. The encoded protein dissociates from the centrosomes when parental centrioles separate at the beginning of mitosis. The protein associates with and is phosphorylated by NIMA-related kinase 2, which is also associated with the centrosome. Furthermore, CEP135 is also required for the centriolar localization of CEP250.

Serine/threonine-protein kinase 38-like is an enzyme that in humans is encoded by the STK38L gene.

Serine/threonine-protein kinase Nek3 is an enzyme that in humans is encoded by the NEK3 gene.

Serine/threonine-protein kinase 10 is an enzyme that in humans is encoded by the STK10 gene.

Serine/threonine-protein kinase Sgk2 is an enzyme that in humans is encoded by the SGK2 gene.

Serine/threonine-protein kinase, Intestinal cell kinase or ICK is an enzyme that in humans is encoded by the ICK gene.

NIMA -related kinase 1, also known as NEK1, is a human gene highly expressed in germ cells and thought to be involved in meiosis. It is also involved in the response to DNA damage from radiation; defects in this gene can be a cause of polycystic kidney disease. NEK1 is thought to be involved in amytrophic lateral sclerosis.

Serine/threonine-protein kinase PCTAIRE-2 is an enzyme that in humans is encoded by the PCTK2 gene.

Serine/threonine-protein kinase 25 is an enzyme that in humans is encoded by the STK25 gene.

Serine/threonine-protein kinase 40 is an enzyme that in humans is encoded by the STK40 gene.

Cyclin-dependent kinase-like 2 is an enzyme that in humans is encoded by the CDKL2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000160602 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000017405 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: NIMA (never in mitosis gene a)- related kinase 8".
↑ Otto EA, Trapp ML, Schultheiss UT, Helou J, Quarmby LM, Hildebrandt F (March 2008). "NEK8 mutations affect ciliary and centrosomal localization and may cause nephronophthisis". J. Am. Soc. Nephrol. 19 (3): 587–92. doi:10.1681/ASN.2007040490. PMC 2391043 . PMID 18199800.
↑ Lancaster MA, Gleeson JG (June 2009). "The primary cilium as a cellular signaling center: lessons from disease". Curr. Opin. Genet. Dev. 19 (3): 220–9. doi:10.1016/j.gde.2009.04.008. PMC 2953615 . PMID 19477114.
↑ Zalli, D.; Bayliss, R.; Fry, A. M. (21 November 2011). "The Nek8 protein kinase, mutated in the human cystic kidney disease nephronophthisis, is both activated and degraded during ciliogenesis". Human Molecular Genetics. 21 (5): 1155–1171. doi:10.1093/hmg/ddr544. PMC 3277313 . PMID 22106379.

Bowers AJ, Boylan JF (2004). "Nek8, a NIMA family kinase member, is overexpressed in primary human breast tumors". Gene. 328: 135–42. doi:10.1016/j.gene.2003.12.002. PMID 15019993.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Valkova N, Yunis R, Mak SK, et al. (2005). "Nek8 mutation causes overexpression of galectin-1, sorcin, and vimentin and accumulation of the major urinary protein in renal cysts of jck mice". Mol. Cell. Proteomics. 4 (7): 1009–18. doi: 10.1074/mcp.M500091-MCP200 . PMID 15872312.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Holland PM, Milne A, Garka K, et al. (2002). "Purification, cloning, and characterization of Nek8, a novel NIMA-related kinase, and its candidate substrate Bicd2". J. Biol. Chem. 277 (18): 16229–40. doi: 10.1074/jbc.M108662200 . PMID 11864968.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Simms RJ, Eley L, Sayer JA (2009). "Nephronophthisis". Eur. J. Hum. Genet. 17 (4): 406–16. doi:10.1038/ejhg.2008.238. PMC 2986221 . PMID 19066617.
Wu C, Ma MH, Brown KR, et al. (2007). "Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening". Proteomics. 7 (11): 1775–85. doi:10.1002/pmic.200601006. PMID 17474147. S2CID 22474278.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000160602 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000017405 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: NIMA (never in mitosis gene a)- related kinase 8".

[pmid18199800-6] Otto EA, Trapp ML, Schultheiss UT, Helou J, Quarmby LM, Hildebrandt F (March 2008). "NEK8 mutations affect ciliary and centrosomal localization and may cause nephronophthisis". J. Am. Soc. Nephrol. 19 (3): 587–92. doi:10.1681/ASN.2007040490. PMC 2391043 . PMID 18199800.

[pmid19477114-7] Lancaster MA, Gleeson JG (June 2009). "The primary cilium as a cellular signaling center: lessons from disease". Curr. Opin. Genet. Dev. 19 (3): 220–9. doi:10.1016/j.gde.2009.04.008. PMC 2953615 . PMID 19477114.

[doi:10.1093/hmg/ddr544-8] Zalli, D.; Bayliss, R.; Fry, A. M. (21 November 2011). "The Nek8 protein kinase, mutated in the human cystic kidney disease nephronophthisis, is both activated and degraded during ciliogenesis". Human Molecular Genetics. 21 (5): 1155–1171. doi:10.1093/hmg/ddr544. PMC 3277313 . PMID 22106379.

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v t e Ciliary proteins
Nephrocystin	NPHP1 INVS NPHP3 NPHP4 IQCB1 CEP290 GLIS2 RPGRIP1L
Basal body	BBsome BBS1 BBS2 BBS4 BBS5 BBS7 TTC8 BBS9 chaperone MKKS BBS10 BBS12 Other ARL6 TRIM32 ALMS1 CC2D2A CEP290 MKS1 RPGRIP1L OFD1 AHI1 INVS NPHP4 NEK8 NPHP1
Cilia	connecting cilia LCA5 RP1 RPGR RPGRIP1 TULP1 primary cilia ARL13B INPP5E IQCB1 PKHD1 PKD1 PKD2 TMEM67
Dynein	outer dynein arms DNAH5 DNAI2 DNAL1 axoneme DNAH11 DNAI1
Radial spokes	RSPH1 RSPH3 RSPH4A RSPH6A RSPH9 RSPH10B
Other	cytoplasm KTU nucleus GLIS2 intraflagellar transport IFT80 other AHI1 ARL13B BRCC3 INPP5E KIF3A LRRC50 SDCCAG8 TMEM216 TXNDC3
see also: ciliopathy

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

NEK8

Contents

Function

Clinical significance

Related Research Articles

References

Further reading