L-arabinose isomerase | |||||||||
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![]() L-arabinose isomerase hexamer, Geobacillus kaustophilus | |||||||||
Identifiers | |||||||||
EC no. | 5.3.1.4 | ||||||||
CAS no. | 9023-80-7 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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Arabinose isomerase | |||||||||
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![]() crystal structure of l-arabinose isomerase from e.coli | |||||||||
Identifiers | |||||||||
Symbol | Arabinose_Isome | ||||||||
Pfam | PF02610 | ||||||||
InterPro | IPR003762 | ||||||||
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In enzymology, a L-arabinose isomerase (EC 5.3.1.4) is an enzyme that catalyzes the chemical reaction
Hence, this enzyme has one substrate, L-arabinose, and one product, L-ribulose.
This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting aldoses and ketoses. The systematic name of this enzyme class is L-arabinose aldose-ketose-isomerase. This enzyme participates in pentose and glucuronate interconversions.
This enzyme catalyses the conversion of L-arabinose to L-ribulose as the first step in the pathway of L-arabinose utilization as a carbon source. [1]
In 1993, scientists discovered that L-arabinose isomerase from the bacterium Lactobacillus gayonii can convert D-Galactose to D-Tagatose. [2] Tagatose is a biologically rare sugar that has been explored as an alternative sweetening agent in foods due to its low glycemic index. [3] [4] L-arabinose isomerase has been explored as a biological method for producing this sugar industrially. [5]
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2AJT and 2HXG.