List of intestinal epithelial differentiation genes

Last updated

Table of genes implicated in development and differentiation of the intestinal epithelium [1]

The table listed below is a running comprehensive list of all intestinal differential genes that have been reported in the literature. The PMID is the pubmed identification number of the papers that support the summarized information in the table corresponding to each row.

OfficialCommonFunction/phenotypePMID
APC Conditional deletion promotes Paneth cell differentiation at the expense of enterocyte, goblet and enteroendocrine cell differentiation. Negative regulator of beta-catenin 15716339 [2]
ATOH1 Math1, HATH1Commitment to secretory lineage20691176 [3] 17570220 [4] 11739954 [5]
BLIMP1 PRDM1Postnatal epithelial maturation; suckling/weaning transition21878906 [6] 21670299 [7]
BMPR1A Involved in terminal differentiation of secretory cells17678919 [8]
CBFA2T2 Mtgr1Required for maintenance of secretory lineage16227606 [9]
CDH1 E-cadherinRequired for maturation/localization of Paneth and goblet cells21179475 [10]
CDX1 Cdx1Induced expression promoted enterocyte differentiation in IEC6 cells19059241 [11] 10579974 [12]
CDX2 Cdx2Involves in epithelial cell maturation as well as goblet and Paneth cell differentiation. Required for the small intestinal identity during development. In IEC-6 cells, conditional expression induced enterocyte and goblet like cells21081128 [13] 19386267 [14] 8552090 [15]
CTNNB1 Catenin, beta Paneth cell differentiation. Essential for stem cell/crypt maintenance. Villus and crypt morphogenesis with Tcf3 via c-Myc18948094 [16] 17785439 [17] 17681174 [18]
DLL1 Functions as a cis acting element and required for goblet cell differentiation in the Notch inactive colonic epithelia. Notch ligand in intestine. Required for the maintenance of stem and progenitors 20170633 [19] 21238454 [20]
DLL4 Notch ligand in intestine. Required for the maintenance of stem and progenitors 21238454 [20]
ELF3 ESE-1Terminal differentiation of absorptive enterocytes 19801644 [21]
EPHB3 Localization of Paneth cells to crypt base12408869 [22]
FGF7 KGFRegulate epithelial growth and promote differentiation 19326389 [23]
FGFR3 Paneth cell specification through beta-catenin/Tcf4 dependent and independent pathway. Significant reduction in Paneth cell in knockout mice. Involved in crypt development and stem cell expansion19407216 [24]
FOXA1 HNF3AInvolved in goblet cell differentiation and enteroendocrine differentiation 19737569 [25]
FOXA2 HNF3BInvolved in goblet cell differentiation and enteroendocrine differentiation 19737569 [25]
FZD5 Required for Paneth cell maturation. Loss of Paneth cell genes after conditional deletion15778706 [26]
GADD45GIP1 Crif1Essential Elf3 coactivator in differentiation of absorptive enterocytes 19801644 [21]
GATA6 Regulates proximal-distal identity in the intestines 21262227 [27]
GATA4 Required for proximal intestinal identity16940177 [28] 18812176 [29]
GFI1 Required for proper allocation of secretory lineage16230531 [30]
HES1 Hes1Commitment to absorptive lineage10615124 [31]
HNF1A HNF1-αRegulates terminal differentiation of enterocytes and secretory cells potentially by direct regulation of Atoh120133952 [32] 20388655 [33]
HNF1B HNF1-βRegulates terminal differentiation of enterocytes and secretory cells potentially by direct regulation of Atoh120133952 [32] 20388655 [33]
IHH Colonocytes differentiation 14770182 [34]
KLF4 GKLFPromotes goblet cell differentiation in colon 21070761 [35] 12015290 [36]
LGR4 GPR48Promotes Paneth cell differentiation and crypt cell proliferation. Along with LGR5, acts as the receptor for R-Spondin, a WNT co-ligand that amplifies WNT signaling21508962 [37] 21909076 [38]
LGR5 GPR49Premature paneth cell differentiation in fetal intestine. Intestinal stem cell marker. Along with LGR4, acts as the receptor for R-Spondin, a WNT co-ligand that amplifies WNT signaling19394326 [39] 21727895 [40]
MMP9 Negatively regulates terminal differentiation of goblet cells in colon 17484881 [41]
MSI1 Suppress paneth cell differentiation independent of Notch and Wnt signaling pathways19214660 [42]
MYBL2 Regulates commitment of colon stem cells to differentiate 20857481; [43] 20133952 [44]
MYC Crypt loss upon conditional deletion in the adult16954380 [45]
NEUROD1 BETA2 Differentiation of Ngn3 enteroendocrine cells into CCK and secretin cells18022152; [46] 15044355 [47]
NEUROG3 NGN3, ATOH5Commitment to the enteroendocrine cell lineage17706959; [48] 12456641 [49]
NKX2-2 Nkx2.2Required for a subset of enteroendocrine cells differentiation 18022152 [46]
NOTCH1 Regulates absorptive cells vs secretory cells15959516; [50] 18274550 [51]
NOTCH2 Regulates absorptive cells vs secretory cells15959516; [50] 18274550 [51]
NOX1 Regulate ROS to activate Notch signaling and indirectly promote absorptive cell lineage in the colon 20351171 [52]
PAX6 Differentiation of GIP in enteroendocrine lineage18022152; [46] 10478839 [53]
PDX1 IPF1Overexpression causes differentiation of immature intestinal epithelia to enteroendocrine cells. Conditional deletion alters enterocyte and enteroendocrine gene expression11408276; [54] 19808654 [55]
PPARD PPAR-δ/βInvolves in Paneth cell maturation by modulating IHH expression16890607 [56]
PTK6 BRKPromote cell cycle exit in Wnt independent pathway and promote enterocyte differentiation 16782882 [57]
RB1 pRBRequired for enterocyte terminal differentiation in small intestine18981186 [58]
RBPJ CBF1Conversion of progenitors and differentiated cells into goblet cells by conditional deletion15959515 [59]
REG4 Marker for enteroendocrine cells
26287467 [60]
SOX9 Required for paneth cell differentiation 17698607; [61] 17681175 [62]
SPDEF PDEFRegulates terminal differentiation of goblet cells and Paneth cells19786015; [63] 19549527 [64]
STK11 LKB1Required for normal differentiation of goblet and Paneth cells19165340 [65]
TGFBR2 Tgf-βRIIThe critical downstream target of Elf3 for enterocyte differentiation 17408644 [66]
VAV Required for enterocyte differentiation in mouse cecum and colon 19139088 [67]

References

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