LGR4

LGR4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4KT1, 4QXE, 4QXF
Identifiers
Aliases	LGR4 , BNMD17, GPR48, leucine-rich repeat containing G protein-coupled receptor 4, leucine rich repeat containing G protein-coupled receptor 4, DPSL
External IDs	OMIM: 606666 MGI: 1891468 HomoloGene: 10226 GeneCards: LGR4
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p14.1 Start 27,365,961 bp [1] End 27,472,790 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 E3 Start 109,747,992 bp [2] End 109,844,602 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas hair follicle rectum metanephros metanephric glomerulus germinal epithelium kidney tubule palpebral conjunctiva right uterine tube liver Top expressed in hand otolith organ utricle renal corpuscle ciliary body left colon Epithelium of stomach kidney ileum urothelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signal transducer activity protein binding transmembrane signaling receptor activity G protein-coupled receptor activity protein-hormone receptor activity G protein-coupled peptide receptor activity Cellular component integral component of membrane membrane integral component of plasma membrane plasma membrane Biological process hair follicle development G protein-coupled receptor signaling pathway cell differentiation positive regulation of branching involved in ureteric bud morphogenesis male genitalia development metanephric nephron tubule morphogenesis rhythmic process metanephric glomerulus development immune system process epithelial cell proliferation Wnt signaling pathway tube morphogenesis positive regulation of transcription, DNA-templated multicellular organism development cell differentiation involved in metanephros development intestinal stem cell homeostasis epithelial cell proliferation involved in renal tubule morphogenesis circadian rhythm canonical Wnt signaling pathway involved in metanephric kidney development digestive tract development innate immune response negative regulation of transcription, DNA-templated signal transduction positive regulation of canonical Wnt signaling pathway bone remodeling circadian regulation of gene expression spermatogenesis osteoblast differentiation bone mineralization negative regulation of toll-like receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway activation of adenylate cyclase activity hormone-mediated signaling pathway negative regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55366 107515 Ensembl ENSG00000205213 ENSMUSG00000050199 UniProt Q9BXB1 A2ARI4 RefSeq (mRNA) NM_018490 NM_001346432 NM_172671 RefSeq (protein) NP_001333361 NP_060960 NP_766259 Location (UCSC) Chr 11: 27.37 – 27.47 Mb Chr 2: 109.75 – 109.84 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Leucine-rich repeat-containing G-protein coupled receptor 4 is a protein that in humans is encoded by the LGR4 gene. ^{[5] [6]} LGR4 is known to have a role in the development of the male reproductive tract, eyelids, hair and bone.

Mutations in this gene have been associated to osteoporosis (doi:10.1038/nature12124).

References

1. GRCh38: Ensembl release 89: ENSG00000205213 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000050199 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Loh ED, Broussard SR, Liu Q, Copeland NG, Gilbert DJ, Jenkins NA, Kolakowski LF Jr (Aug 2000). "Chromosomal localization of GPR48, a novel glycoprotein hormone receptor like GPCR, in human and mouse with radiation hybrid and interspecific backcross mapping". Cytogenet Cell Genet. 89 (1–2): 2–5. doi:10.1159/000015576. PMID   10894923. S2CID   607389.
6. "Entrez Gene: LGR4 leucine-rich repeat-containing G protein-coupled receptor 4".

Further reading

• Hsu SY, Liang SG, Hsueh AJ (1999). "Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region". Mol. Endocrinol. 12 (12): 1830–45. doi: 10.1210/me.12.12.1830 . PMID   9849958.
• Loh ED, Broussard SR, Kolakowski LF (2001). "Molecular characterization of a novel glycoprotein hormone G-protein-coupled receptor". Biochem. Biophys. Res. Commun. 282 (3): 757–64. doi:10.1006/bbrc.2001.4625. PMID   11401528.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.