| Train Name | Railroad | Train Endpoints in a typical [year] | Operated |
|---|
| Namakagon | Omaha Road | Minneapolis, Minnesota–Ashland, Wisconsin | 1939–1950 |
| Nancy Hanks II | Central of Georgia | Atlanta, Georgia–Savannah, Georgia [1953] | 1947–1971 |
| Napa Valley Wine Train | Napa Valley Railroad | Napa, California–St. Helena, California [2016] | 1989–present |
| Narragansett | Pennsylvania Railroad New Haven Railroad | Philadelphia–Boston [1948] | 1925–1957 |
| Narragansett | Amtrak | New York, New York–Boston, Massachusetts [1972] | 1971–1972; 1976; 1984–1994; 1997–1998 |
| Nashville-Chicago Limited | Chicago and Eastern Illinois Railroad, Louisville and Nashville Railroad | Chicago, Illinois–Nashville, Tennessee–Jacksonville, Florida [1924] | 1892–1903 (called Nashville and Chicago Limited); 1907–1913; 1919–1925 |
| Nathan Hale | New Haven | New York, New York–Springfield, Massachusetts [1970] | 1942–1971 |
| Nathan Hale | Amtrak | Washington, DC–Springfield, Massachusetts [1985] | 1984–1987 |
| National Limited | Baltimore & Ohio | Jersey City, New Jersey–St. Louis, Missouri [1948] | 1925–1971 |
| National Limited | Amtrak | New York, New York–Kansas City, Missouri [1973] | 1971–1979 |
| National Limited | West Shore Railroad, Wabash Railroad | New York, New York–St. Louis, Missouri–Boston, Massachusetts–Chicago, Illinois [1904] | 1904–1910 |
| National Parks Special | Chicago & Northwestern, Union Pacific Railroad | Chicago, Illinois–Minneapolis–Saint Paul–Denver, Colorado–West Yellowstone, Montana [1940] | 1940–1941; 1950–1955 |
| Naugatuk | New York, New Haven, & Hartford | New York, New York–Winsted, Connecticut [1949] | 1947–1953 |
| Navajo | Santa Fe | Chicago, Illinois–Los Angeles, California [1934] | 1915–1939 |
| Nebraska Limited | Chicago Great Western | Minneapolis–Saint Paul–Omaha, Nebraska [1921] | 1916–1952 |
| Nebraska Limited | Chicago, Burlington & Quincy | Chicago, Illinois–Lincoln, Nebraska [1923] | 1917; 1923–1928 |
| Nebraska Zephyr | Chicago, Burlington & Quincy | Chicago, Illinois–Lincoln, Nebraska [1955] | 1947–1971 |
| Nebraska-Chicago Limited | Chicago, Burlington & Quincy | Chicago, Illinois–Omaha, Nebraska [1910] | 1910–1916 |
| Nellie Bly | Pennsylvania–Pennsylvania–Reading Seashore Lines | New York City–Atlantic City, New Jersey–Washington, D.C.–Atlantic City, New Jersey [1928] | 1926–1942; 1950–1961 |
| Neptune | New Haven | New York City–Woods Hole, Massachusetts [1940] | 1937–1942; 1946–1958; 1960-1964 |
| New England Express | New York Central and its affiliates | New York City–Boston–Chicago [1904] | 1901–1909; 1921–1928 |
| New England Express | Pennsylvania Railroad–New Haven Railroad | Pittsburgh–Boston [1925] | 1920–1930 |
| New England Express | Amtrak | New York City–Boston [1991] | 1991–1995 |
| New England Express | Boston and Maine, Canadian Pacific Railway | Boston, Massachusetts–Montreal, Quebec [1903] | 1903–1910 |
| New England Special | New York Central and its affiliates | Chicago, Illinois–Boston, Massachusetts [1913] | 1901–1925 |
| New England States | New York Central Penn Central | Chicago, Illinois–Boston, Massachusetts [1942] | 1938–1967 |
| New England States Limited | Central Vermont Railway, Boston and Maine, New York, New Haven and Hartford Railroad | New York, New York–Montreal, Quebec–Boston, Massachusetts [1916] | 1906–1917 |
| New England Wolverine | New York Central | Chicago, Illinois–Boston, Massachusetts (endpoints varied by year) [1952] | 1911–1933; 1942–1956 |
| New England Zip | Amtrak | Boston–Washington, D.C. [1982] | 1982–1983 |
| New Englander | Central Vermont Railway, Boston and Maine, Canadian National Railway | Boston–Montreal, Quebec [1948] | 1927–1953 |
| New Englander | Pennsylvania Railroad New Haven Railroad | Pittsburgh–Boston [1930] | 1929–1961 |
| New Englander | Amtrak | Boston–Philadelphia [1974] | 1974–1975 |
| New Mexico, Utah and California Express | Denver and Rio Grande Railroad | Denver, Colorado–Ogden, Utah [1901] | 1901–1905 |
| New Orleans and Chicago Limited | Illinois Central | Chicago, Illinois–New Orleans, Louisiana [1906] | 1897–1910 |
| New Orleans and Memphis Express | Illinois Central | St. Louis, Missouri–New Orleans, Louisiana [1914] | 1912–1917 |
| New Orleans and St. Louis Limited | Illinois Central | St. Louis, Missouri–New Orleans, Louisiana [1904] | 1897–1910 |
| New Orleans Limited | Queen and Crescent Route (Southern Railway from 1917) | Cincinnati, Ohio–New Orleans, Louisiana [1925] | 1895; 1911–1919; 1923–1926 |
| New Orleans Limited | Louisville and Nashville Railroad | Cincinnati, Ohio–New Orleans, Louisiana [1930] | 1917–1936 |
| New Orleans Limited | Illinois Central | Chicago, Illinois–St. Louis, Missouri–New Orleans, Louisiana [1922] | 1913; 1917–1930 |
| New Orleans Limited | Southern Pacific | Houston, Texas–New Orleans, Louisiana [1925] | 1923–1934 |
| New Orleans Special | Illinois Central | Chicago, Illinois–St. Louis, Missouri–New Orleans, Louisiana [1922] | 1900–1930 |
| New Orleans Special | Southern Railway | Cincinnati, Ohio–New Orleans, Louisiana (with through cars to other points) [1928] | 1925–1930 |
| New Orleans Special | Chicago and Eastern Illinois Railroad, Louisville and Nashville Railroad | Chicago, Illinois–New Orleans, Louisiana (with through cars to other points) [1916] | 1902–1903; 1906–1931 |
| New Orleans-Florida Express | Louisville and Nashville Railroad, Seaboard Air Line Railroad | New Orleans, Louisiana–Jacksonville, Florida [1948] | ca. 1930s–1949 |
| New Orleans-Florida Limited | Louisville and Nashville Railroad, Seaboard Air Line Railroad | New Orleans, Louisiana–Jacksonville, Florida [1926] | 1925–1931; 1937–1949 |
| New Royal Palm | Southern Railway Florida East Coast Railway, New York Central Railroad | Chicago, Illinois–Miami, Florida [1952] | 1949–1955 |
| New York and Atlanta Express | Pennsylvania Railroad, Southern Railway | New York, New York–Atlanta, Georgia [1903] | 1901–1908 |
| New York and Boston Express | New York Central and its affiliates | New York, New York–St. Louis, Missouri–Boston, Massachusetts–Chicago, Illinois [1904] | 1899–1913 |
| New York and Boston Special | Michigan Central and its affiliates | Chicago, Illinois–Boston, Massachusetts–New York, New York [1909] | 1898–1910; 1918–1932 |
| New York and Chicago Express | Lehigh Valley Railroad, Grand Trunk Western Railroad | New York City–Philadelphia–Chicago [1916] | 1908–1916 |
| New York and Florida Special | Pennsylvania Railroad, Richmond, Fredericksburg and Potomac Railroad, Atlantic Coast Line Railroad, Florida East Coast Railway | New York, New York–Key West, Florida | 1888–1920 |
| New York and Memphis Limited | Pennsylvania Railroad, Southern Railway | New York, New York–Memphis, Tennessee [1906] | 1902–1909 |
| New York and New England Express | New York Central and its affiliates | New York, New York–St. Louis, Missouri–Boston, Massachusetts–Chicago, Illinois [1904] | 1901–1925 |
| New York and New England Special | New York Central and its affiliates | New York, New York–St. Louis, Missouri–Boston, Massachusetts–Cincinnati, Ohio [1912] | 1910–1930 |
| New York and New Orleans Limited | Pennsylvania Railroad, Southern Railway, Atlanta and West Point Railroad | New York, New York–New Orleans, Louisiana [1910] | 1907–1925 |
| New York and Norfolk Express | Pennsylvania | New York, New York–Cape Charles, Virginia [1913] | 1894–1917 |
| New York and Philadelphia Day Express | Lehigh Valley Railroad, Reading Railroad | New York City–Philadelphia [1908] | 1908–1916 |
| New York and Philadelphia Express | Lehigh Valley Railroad, Grand Trunk Western Railroad | New York City–Philadelphia–Chicago, Illinois [1903] | 1894–1916 |
| New York and Washington Express | Pennsylvania | New York, New York–Washington, DC [1930] | 1974-1905; 1909; 1913–1949 |
| New York Central Limited | New York Central and its affiliates | New York, New York–Boston, Massachusetts–Chicago, Illinois [1913] | 1896; 1910–1924 |
| New York Clocker (group of trains) | Central Railroad of New Jersey | Allentown, Pennsylvania–Jersey City, New Jersey [1955] | 1954–1963 |
| New York Day Express | Pennsylvania | New York, New York–Pittsburgh, Pennsylvania [1915] | 1906–1927 |
| New York Day Express | Boston and Albany Railroad, New Haven Railroad | New York, New York–Boston, Massachusetts [1922] | 1910; 1919–1931 |
| New York Day Express | Delaware, Lackawanna and Western Railroad | New York, New York–Scranton, Pennsylvania | 1919–1927; 1934 |
| New York Executive | Amtrak | New York, New York–Washington, DC [1984] | 1984–1986 |
| New York Express | New York Central and its affiliates | New York, New York–Chicago, Illinois [1926] | 1877–1894; 1901–1918; 1926–1928; 1933–1941 |
| New York Express | Erie Railroad | Jersey City, New Jersey–Chicago, Illinois [1930] | 1929–1933 |
| New York Express | Boston and Albany Railroad, New Haven Railroad | New York, New York–Boston, Massachusetts [1940] | 1882–1886; 1926–1946 |
| New York Express | Pennsylvania | New York, New York–St. Louis, Missouri [1915] | 1903–1928 |
| New York Express | New York Central, Rutland Railroad | New York, New York–Montreal, Quebec [1916] | 1913–1918 |
| New York Express | Delaware, Lackawanna and Western Railroad | New York, New York–Buffalo, New York (with through cars to other New York destinations) [1920] | 1919–1924; 1933–1936 |
| New York Express | New York Central | North Adams, Massachusetts--New York, New York [1922] | 1919–1932 |
| New York Express | Long Island Rail Road | New York, New York–Montauk, New York [1940] | 1929–1941; 1947–1949 |
| New York Limited | Pennsylvania | New York, New York–Cincinnati, Ohio–St. Louis, Missouri [1904] | 1904–1910 |
| New York Limited | New York Central and its affiliates | New York, New York–Cleveland, Ohio–Chicago, Illinois–Cincinnati, Ohio [1924] | 1910; 1921–1941 |
| New York Limited | Delaware, Lackawanna and Western Railroad | New York, New York–Buffalo, New York [1920] | 1919–1924 |
| New York Limited | Pennsylvania | New York, New York–Atlantic City, New Jersey [1925] | 1923–1931 |
| New York Limited Express | Pennsylvania | New York, New York–Washington, D.C. [1901] | 1874–1904 |
| New York Mail | Delaware, Lackawanna and Western Railroad, New York, Chicago and St. Louis Railroad | Chicago, Illinois-New York City [1938]; Buffalo, New York-Hoboken, New Jersey [1958] | 1937–1968 |
| New York Mail | Pennsylvania | New York, New York–Pittsburgh, Pennsylvania [1915] | 1913–1920 |
| New York Night Express | Baltimore & Ohio Railroad Central Railroad of New Jersey Reading Railroad | Jersey City, New Jersey–Washington, D.C. [1940] | 1938–1952 |
| New York Scenic Express | Erie Railroad | Jersey City, New Jersey–Chicago, Illinois [1925] | 1922–1928 |
| New York Special | New York Central | New York, New York–Chicago, Illinois [1952] | 1910–1967 |
| New York Special | Erie Railroad | Jersey City, New Jersey–Akron, Ohio [1903] | 1897–1915 |
| New York State Express | New York Central and its affiliates | Boston, Massachusetts–Buffalo, New York [1930] | 1927–1941 |
| New York-Berkshire Express | New York Central | New York, New York–Boston, Massachusetts–Albany, New York [1943] | 1942–1952 |
| New York-Boston Express | Boston and Albany Railroad, New Haven Railroad | New York, New York–Boston, Massachusetts [1940] | 1923–1952 |
| New York-Chicago Special | Baltimore and Ohio Railroad | Jersey City, New Jersey–Chicago, Illinois [1925] | 1919–1934 |
| New York-Cincinnati-St. Louis Express | Baltimore and Ohio Railroad | Jersey City, New Jersey–St. Louis, Missouri [1915] | 1913–1936 |
| New York-Cincinnati-St. Louis Limited | Baltimore and Ohio Railroad | Jersey City, New Jersey–St. Louis, Missouri [1915] | 1913–1936 |
| New York-Cincinnati-St. Louis Special | Baltimore and Ohio Railroad | Jersey City, New Jersey–St. Louis, Missouri [1928] | 1925–1930 |
| New York-Cleveland Express | Erie Railroad | Jersey City, New Jersey–Cleveland, Missouri [1925] | 1922–1927 |
| New York-Florida Limited | Pennsylvania Railroad, Richmond, Fredericksburg and Potomac Railroad, Seaboard Air Line Railroad | New York, New York–Miami, Florida–St. Petersburg, Florida [1930] | 1927–1941 |
| New York-Pittsburgh-Chicago Express | Baltimore and Ohio Railroad | Jersey City, New Jersey–Chicago, Illinois [1932] | 1913–1914; 1931–1934; 1939–1944 |
| New York-Richmond Express | Pennsylvania Railroad, Richmond, Fredericksburg and Potomac Railroad | New York, New York–Richmond, Virginia [1914] | 1912–1918 |
| New York-Washington-Atlanta-New Orleans Express | Pennsylvania, Southern Railway, Atlanta and West Point Railroad, Louisville and Nashville Railroad | New York, New York–New Orleans, Louisiana [1934] | 1920–1943 |
| New York-Washington-New Orleans Express | Pennsylvania, Southern Railway | New York, New York–New Orleans, Louisiana [1934] | 1931–1935 |
| New York, Atlanta and New Orleans Limited | Pennsylvania, Southern Railway | New York, New York–New Orleans, Louisiana [1910] | 1910–1915 |
| New York, Boston and Chicago Special | New York Central and its affiliates | New York, New York–Boston, Massachusetts–Chicago, Illinois–Cincinnati, Ohio [1912] | 1895–1900; 1912–1916 |
| New York, Pittsburgh and Chicago Limited | Baltimore and Ohio Railroad | Jersey City, New Jersey–Chicago, Illinois [1911] | 1911–1916 |
| New Yorker | Amtrak | New York, New York–Washington, DC [1991] | 1973–1976; 1980–1982; 1991–1998 |
| New Yorker | Lackawanna Railroad Nickel Plate | Chicago, Illinois–Hoboken, New Jersey [1938] | 1936–1961 |
| New Yorker | Pennsylvania | New York, New York–Chicago, Illinois (with sections to other cities) [1937] | 1916–1927; 1930–1947 |
| New Yorker | New York Central | New York, New York–Chicago, Illinois [1911] | 1904–1928 |
| New Yorker | Pennsylvania, Southern Railway | New York, New York–Atlanta, Georgia [1948] | 1948–1953 |
| New Yorker | New Haven | New York, New York–Boston, Massachusetts [1940] | 1925–1971 |
| New Yorker | Lehigh Valley Railroad, Grand Trunk Western Railroad | New York, New York–Chicago, Illinois [1928] | 1925–1932 |
| New Yorker | Detroit and Mackinac Railway | Detroit, Michigan–Alpena, Michigan [1938] | 1936–1946 |
| Newarker | Central Railroad of New Jersey | New York, New York–Bay Head, New Jersey [1942] | 1942–1949 |
| Newspaper Special | Pennsylvania | New York, New York–Williamsport, Pennsylvania [1920] | 1919–1923 |
| Niagara | New York Central | Chicago, Illinois–Buffalo, New York, via Detroit, Michigan [1948] | 1926–1949 |
| Niagara-Canadian | New York Central, Canadian Pacific Railway | Chicago, Illinois–Buffalo, New York and Toronto, Ontario, via Detroit, Michigan [1948] | 1942–1946 |
| Niagara | Pennsylvania | Philadelphia–Niagara Falls, New York [1922] | 1920–1932 |
| Niagara Falls and Eastern Express | Michigan Central | Chicago–Boston–New York City [1906] | 1906–1934 |
| Niagara Rainbow | Amtrak | New York, New York–Detroit, Michigan [1976] New York, New York–Albany, New York–Niagara Falls, Ontario–Toronto, Ontario [1994] | 1974–1976 as the Empire State Express; 1976–1979; 1994–1995 |
| Nickel Plate Limited | Delaware, Lackawanna and Western Railroad, New York, Chicago and St. Louis Railroad | New York, New York–Chicago, Illinois [1930] | 1929–1954 |
| Nicollete | Amtrak | Chicago, Illinois–Milwaukee, Wisconsin [1980] | 1980–1989 |
| Nieuw Amsterdam | Amtrak | New York, New York–Albany, New York [1991] | 1991; 1995 |
| Night Cap | Amtrak | New York, New York–Washington, DC [1971] | 1971–1975 |
| Night Cape Codder | New Haven | New York, New York–Woods Hole, Massachusetts [1940] | 1937–1941; 1948–1958 |
| Night Diamond | Illinois Central | Chicago, Illinois–St. Louis, Missouri [1950] | 1947–1958 |
| Night Express | Baltimore and Ohio Railroad Chesapeake and Ohio Railway | Detroit, Michigan–Cincinnati, Ohio [1966] | 1960–1967 |
| Night Express | Central Vermont, Boston and Maine | Boston, Massachusetts–Montreal, Quebec [1916] | 1911–1918 |
| Night Express | Chicago, Indianapolis & Louisville | Chicago, Illinois–Cincinnati, Ohio [1921] | 1921–1922 |
| Night Express | Cleveland, Cincinnati, Chicago and St. Louis Railway | Peoria, Illinois–Indianapolis, Indiana [1918] | 1915–1941 |
| Night Express | Cleveland, Cincinnati, Chicago and St. Louis Railway | Chicago, Illinois–Cincinnati, Ohio [1923] | 1923–1930 |
| Night Express | Grand Rapids & Indiana | Chicago, Illinois–Grand Rapids, Michigan [1904] | 1904–1918 |
| Night Express | Lake Shore and Michigan Southern Railway | Chicago, Illinois–Cleveland, Ohio [1903] | 1901–1914 |
| Night Express | Milwaukee Road Railroad | Chicago, Illinois–Minneapolis–Saint Paul [1905] | 1883–1886; 1904–1910 |
| Night Express | New Haven | New York, New York–Boston, Massachusetts [1922] | 1881–1909; 1919–1934 |
| Night Express | New York Central, Rutland Railroad, Canadian Pacific Railway | New York, New York–Montreal, QC (with through cars to Ottawa, ON) [1903] | 1900–1912 |
| Night Express | Northern Pacific Railway | Minneapolis–Saint Paul–Duluth, Minnesota [1901] | 1901–1905 |
| Night Express | Pere Marquette | Chicago, Illinois–Traverse City, Michigan and Muskegon, Michigan [1930] | 1920–1946 |
| Night Express | Texas and Pacific Railway, Missouri Pacific Railroad | St. Louis, Missouri–Fort Worth, Texas (with through cars to other destinations) [1916] | 1900–1918 |
| Night Hawk | Chicago and Alton, Chicago, Burlington and Quincy Railroad; Gulf, Mobile and Ohio Railroad from 1947 | St. Louis, Missouri–Kansas City, Missouri [1948] | 1906–1949 |
| Night Owl | Amtrak | Washington, DC–Boston, Massachusetts [1980] | 1972; 1997 |
| Night Special | New York Central | Cincinnati, Ohio-Cleveland, Ohio– [1955] | 1953–1967 |
| Night White Mountains | New Haven, Boston and Maine | New York, New York–Bretton Woods, New Hampshire [1952] | 1926–1940; 1950–1955 |
| Nightingale | Chicago and Alton | Chicago, Illinois–Kansas City, Missouri [1911] | 1909–1918 |
| Nightingale | Chicago & Northwestern | Omaha, Nebraska–Minneapolis–Saint Paul [1952] | 1931–1956 |
| Noon Daylight | Southern Pacific | Los Angeles, California–San Francisco, California [1941] | 1940–1941; 1947–1949 |
| Noon Flyer | Grand Rapids & Indiana | Chicago, Illinois–Grand Rapids, Michigan [1912] | 1904–1918 |
| North Adams and Pittsfield Express | New York Central | New York, New York–North Adams, Massachusetts [1915] | 1914–1921 |
| North Adams Express | New York Central | New York, New York–North Adams, Massachusetts [1908] | 1907–1914 |
| North Adams Special | New York Central | New York, New York–North Adams, Massachusetts [1908] | 1902–1914 |
| North American | Chicago & Northwestern | Chicago, Illinois–Minneapolis–Saint Paul (several different endpoints over the years) [1916] | 1916–1959 |
| North Coast Hiawatha | Amtrak | Chicago, Illinois–Seattle, Washington [1973] | 1971–1979 |
| North Coast Limited | Northern Pacific, Chicago, Burlington and Quincy Railroad | Chicago, Illinois–Seattle, Washington–Tacoma, Washington [1948] | 1900–1971 |
| North Michigan Special | Michigan Central Railroad, Pennsylvania Railroad | Chicago, Illinois–Mackinaw City, Michigan [1922] | 1918–1930 |
| North Penn | Reading Railroad | Philadelphia–Bethlehem, Pennsylvania [1963] | 1961–1968 |
| North Shore Limited | New York Central | New York City–Chicago; Toronto, Ontario-Chicago [1948] | 1884–1897; 1902–1905; 1921–1963 |
| North Star | Amtrak | Chicago–Duluth, Minnesota [1978] | 1978–1986 |
| North Star | New York Central | New York, New York–Toronto, Ontario-Cleveland, Ohio–Lake Placid, New York [1952] | 1947–1962 |
| North Star | Pennsylvania, Michigan Central Railroad | Chicago, Illinois–Mackinaw City, Michigan [1930] | 1930–1932 |
| North Star Limited | Illinois Central Railroad, Minneapolis and St. Louis Railway | Chicago, Illinois–Minneapolis–Saint Paul [1912] | 1903–1918 |
| North Star Limited | Wabash Railroad, Minneapolis and St. Louis Railway | St. Louis, Missouri–Minneapolis–Saint Paul [1912] | 1907–1918 |
| North Texas Limited | Texas and Pacific Railway, Missouri Pacific Railroad | St. Louis, Missouri–Fort Worth, Texas (with though cars to other destinations) [1916] | 1914–1918 |
| North Texas Mail | Santa Fe | Dallas, Texas–Cleburne, Texas [1906] | 1906–1910 |
| North Western Fast Mail | Chicago & Northwestern | Chicago, Illinois–Minneapolis–Saint Paul [1932] | 1932–1937 |
| North Western Limited | Chicago & Northwestern | Chicago, Illinois–Minneapolis–Saint Paul [1914] | 1914–1958 |
| North Western Mail | Chicago & Northwestern | Chicago, Illinois–Minneapolis–Saint Paul [1914] | 1909–1933 |
| North Wind | Boston and Maine, New Haven, Central Vermont Railway, Canadian National Railway | New York, New York–Montreal, Quebec [1955] | 1950–1955 |
| North Woods Fisherman | Chicago & Northwestern | Chicago, Illinois–Ashland, Wisconsin [1960] | 1958–1963 |
| North Woods Hiawatha | Milwaukee Road | Chicago, Illinois–Minocqua, Wisconsin | ? |
| Northeast Regional (group of trains) | Amtrak | various destinations in the Northeast | -present |
| Northeastern Limited | Illinois Central | Shreveport, Louisiana–Meridian, Mississippi [1935] | 1934–1967; westbound counterpart is the Southwestern Limited |
| Northern and Western Express | New York Central | New York, New York–Ogdensburg, New York–Watertown, New York [1910] | 1908–1912 |
| Northern Arrow | Pennsylvania | Cincinnati, Ohio–Mackinaw City, Michigan [1935] | 1935–1942; 1946–1961 |
| Northern Express | New York Central, Delaware and Hudson Railway, Central Vermont Railway | New York, New York–Montreal, Quebec [1892] | 1890–1901 |
| Northern Express | Pennsylvania | Washington, DC–Philadelphia–Erie, Pennsylvania (several different endpoints over the years; terminus shifted from Erie to Buffalo, NY in latter years) [1952] | 1892–1968 |
| Northern Express | Illinois Central | New Orleans, Louisiana–Chicago, Illinois [1948] | 1922–1931; 1943–1952 |
| Northern Michigan Express | Detroit and Mackinac Railway | Detroit, Michigan–Cheboygan, Michigan [1933] | 1919–1935 |
| Northern Michigan Special | Milwaukee Road | Chicago, Illinois–Calumet, Michigan [1915] | 1913–1921 |
| Northern New York Express | New York Central | New York, New York–Ogdensburg, New York–Oswego, New York [1902] | 1902–1907 |
| Northern Pacific Express | Northern Pacific, Chicago, Burlington and Quincy Railroad | Chicago, Illinois–Seattle, Washington–Portland, Oregon [1911] | 1910–1920 |
| Northerner | New York Central | Detroit, Michigan–Mackinaw City, Michigan [1952] | 1952–1962 |
| Northland Express | Pennsylvania | Cincinnati, Ohio–Mackinaw City, Michigan (in some years just called 'Northland' [1924] | 1901–1903; 1923–1935 |
| Northwest Express | Union Pacific | Salt Lake City, Utah–Portland, Oregon [1935] | 1919–1931; 1935–1946 |
| Northwest Special | Union Pacific | Salt Lake City, Utah–Butte, Montana–Spokane, Washington [1952] | 1947–1958 |
| Northwestern Limited | Chicago & Northwestern | Chicago, Illinois–Minneapolis–Saint Paul [1910] | 1892–1912 |
| Number Eighteen | New York Central | Chicago, Illinois–Cincinnati, Ohio–Buffalo, New York–Pittsburgh, Pennsylvania [1935] | 1936–1946 |
| Number Fifty-Five | New York Central | New York, New York–Chicago, Illinois–Boston, Massachusetts [1937] | 1937–1940 |
| Number Forty-Five | New York Central | New York, New York–Utica, New York [1935] | 1934–1945 |
| Number Forty-Four | New York Central | New York, New York–Cleveland, Ohio [1935] | 1933–1941 |
| Number Forty-One | New York Central | New York, New York–Chicago, Illinois [1916] | 1911–1934 |
| Number Four | New York Central | New York, New York–Chicago, Illinois–St. Louis, Missouri [1918] | 1916–1928 |
| Number Seven | New York Central | New York, New York–Cleveland, Ohio–Toronto, Ontario [1935] | 1932–1941 |
| Number Six | New York Central | New York, New York–Chicago, Illinois–Cincinnati, Ohio [1911] | 1911–1920 |
| Number Thirty-One | New York Central | New York, New York–Plattsburgh, New York [1935] | 1933–1937 |
| Number Thirty-Two | Pennsylvania | New York, New York–Washington, DC [1925] | 1922–1928 |
| Number Twenty-Three | New York Central | New York, New York–Chicago, Illinois [1933] | 1932–1936 |
| Number Twenty-Three | New York Central | New York, New York–Chicago, Illinois [1933] | 1932–1936 |
| Nutmeg | New York, New Haven and Hartford | Boston–Waterbury, Connecticut [1955] | 1950-1955 |
| Nutmeg State | Amtrak | Washington, DC–Springfield, Massachusetts [1995] | 1993–1998 |