Charles the Bald (823–877), King of West Francia, King of Italy and Holy Roman Emperor
William I, Duke of Bavaria (1330–1389), also known as William V, Count of Holland, as William III, Count of Hainaut and as William IV, Count of Zeeland
Jakob Heller (c. 1460—1522), patrician, politician, and merchant
Lorenz Heister (1683–1758), anatomist, surgeon and botanist
18th century
Alexander Ferdinand (1704–1773), 3rd Prince of Thurn and Taxis, Postmaster General of the Imperial Reichspost, and Head of the Princely House of Thurn and Taxis
Karl Anselm (1733–1805), 4th Prince of Thurn and Taxis, Postmaster General of the Imperial Reichspost, and Head of the Princely House of Thurn and Taxis
Charlemagne (born between 742 and 748; died 814), King of the Franks who united most of Western Europe during the Middle Ages and laid the foundations for modern France and Germany
Louis the German (c. 810–876), grandson of Charlemagne and third son of the succeeding Frankish Emperor Louis the Pious and his first wife, Ermengarde of Hesbaye
Louis the Younger (born between 830 and 835; died 882), second eldest son of Louis the German and Emma who succeeded his father as King of Saxony and his elder brother Carloman as King of Bavaria
Alois Alzheimer (1864–1915), Bavarian-born psychiatrist and neuropathologist credited with identifying the first published case of "presenile dementia", later identified as Alzheimer's disease
Pope Francis (born Jorge Mario Bergoglio, 1936), pope of the Catholic Church, spent several months at the Sankt Georgen Graduate School of Philosophy and Theology in Frankfurt
F. K. Waechter (1937–2005), cartoonist, author, and playwright
Robert Gernhardt (1937–2006), writer, painter, caricaturist, and poet
Barbara Klemm (born 1939), photographer, worked for Frankfurter Allgemeine Zeitung for 45 years
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