Mevaldate reductase (NADPH)

mevaldate reductase (NADPH)
Identifiers
EC no.	1.1.1.33
CAS no.	9028-34-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a mevaldate reductase (NADPH) (EC 1.1.1.33) is an enzyme that catalyzes the chemical reaction

(R)-mevalonate + NADP⁺${\displaystyle \rightleftharpoons }$ mevaldate + NADPH + H⁺

Thus, the two substrates of this enzyme are (R)-mevalonate and NADP⁺, whereas its 3 products are mevaldate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (R)-mevalonate:NADP⁺ oxidoreductase. Other names in common use include mevaldate (reduced nicotinamide adenine dinucleotide phosphate), reductase, and mevaldate reductase (NADPH).

References

• Schomburg D, Stephan D (1995). "Mevaldate reductase (NADPH).". Enzyme Handbook. Vol. 9. Berlin, Heidelberg: Springer. pp. 189–191. doi:10.1007/978-3-642-85200-8_33. ISBN   978-3-642-85200-8.
• Wolstenholme GE, O'Connor M, eds. (1959). CIBA Symposium on the Biosynthesis of Terpenes and Sterols. London. pp. 62–74.
• Jakoby WB, ed. (1980). Enzymatic Basis of Detoxication. Vol. 1. New York: Academic Press. pp. 249–260.