Malate dehydrogenase (quinone)

malate dehydrogenase (quinone)
Identifiers
EC no.	1.1.5.4
CAS no.	71822-24-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, malate dehydrogenase (quinone) (EC 1.1.5.4), formerly malate dehydrogenase (acceptor) (EC 1.1.99.16), is an enzyme that catalyzes the chemical reaction

(S)-malic acid

+ a quinone

 

 

 

 

 

 

 

oxaloacetic acid

+ a quinol

 

The two substrates of this enzyme are (S)-malic acid and a quinone. Its products are oxaloacetic acid and reduced quinone. The cofactor can be a variety of quinones including vitamin K. ^{[1] [2] [3]}

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with a quinone as acceptor. The systematic name of this enzyme class is (S)-malate:quinone oxidoreductase. Other names in common use include FAD-dependent malate-vitamin K reductase, malate-vitamin K reductase, and (S)-malate:(quinone) oxidoreductase. This enzyme participates in pyruvate metabolism. It employs one cofactor, FAD.

References

1. Enzyme 1.1.5.4 at KEGG Pathway Database.
2. Imai D; Brodie AF (1973). "A phospholipid-requiring enzyme, malate-vitamin K reductase". J. Biol. Chem. 248 (21): 7487–7494. doi: 10.1016/S0021-9258(19)43316-4 .
   • Imai T (1978). "FAD-dependent malate dehydrogenase, a phospholipid-requiring enzyme from Mycobacterium sp. strain Takeo. Purification and some properties". Biochim. Biophys. Acta. 523 (1): 37–46. doi:10.1016/0005-2744(78)90006-2. PMID   629992.
3. Prasada Reddy TL, Suryanarayana Murthy P, Venkitasubramanian TA (1975). "Variations in the pathways of malate oxidation and phosphorylation in different species of Mycobacteria". Biochim. Biophys. Acta. 376 (2): 210–8. doi:10.1016/0005-2728(75)90012-2. PMID   234747.