mir-160 microRNA precursor family | |
---|---|
Identifiers | |
Symbol | mir-160 |
Rfam | RF00247 |
miRBase | MI0000190 |
miRBase family | MIPF0000032 |
Other data | |
RNA type | Gene; miRNA |
Domain(s) | Eukaryota |
GO | GO:0035195 GO:0035068 |
SO | SO:0001244 |
PDB structures | PDBe |
In molecular biology, mir-160 is a microRNA that has been predicted or experimentally confirmed in a range of plant species including Arabidopsis thaliana (mouse-ear cress) and Oryza sativa (rice). [1] miR-160 is predicted to bind complementary sites in the untranslated regions of auxin response factor genes to regulate their expression. [2] The hairpin precursors (represented here) are predicted based on base pairing and cross-species conservation; their extents are not known. In this case, the mature sequence is excised from the 5' arm of the hairpin.
Specifically, 3 of A. thaliana's 23 auxin-response factor genes are thought to be post-transcriptionally regulated by mir-160. [3] [4] When one of these targets (ARF17) is manipulated to become miRNA-resistant, several developmental defects can be observed in the host plant. [3] This experiment has been repeated with another mir-160 target, ARF10, and results highlighted a regulatory role in post-embryonic development and seed germination. [5]
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