Mir-145

MIR145
Identifiers
Aliases	MIR145 , microRNA 145, MIRN145, miR-145, miRNA145, MIRN145 microRNA, human
External IDs	OMIM: 611795; GeneCards: MIR145; OMA:MIR145 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q32 Start 149,430,646 bp [1] End 149,430,733 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right coronary artery gastric mucosa smooth muscle tissue left uterine tube tibial arteries muscle layer of sigmoid colon body of uterus myometrium left coronary artery prostate n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 406937 n/a Ensembl ENSG00000276365 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 5: 149.43 – 149.43 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

mir-145
Conserved secondary structure of mir-145
Identifiers
Symbol	mir-145
Rfam	RF00675
miRBase family	MIPF0000079
Other data
RNA type	microRNA
Domain(s)	Eukaryota;
PDB structures	PDBe

In molecular biology, mir-145 microRNA is a short RNA molecule that in humans is encoded by the MIR145 gene. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. ^[3]

Targets

MicroRNAs are involved in down-regulation of a variety of target genes. Götte et al. have shown that experimental over-expression of mir-145 down-regulates the junctional cell adhesion molecule JAM-A as well as the actin bundling protein fascin in breast cancer and endometriosis cells, resulting in a reduction of cell motility. ^{[4] [5]} Larsson et al. ^[6] showed that miR-145 targets the 3' UTR of the FLI1 gene, a finding that was later supported by Zhang et al. ^[7]

Role in cancer

miR-145 is hypothesised to be a tumor suppressor. ^[8] miR-145 has been shown to be down-regulated in breast cancer. ^[5] miR-145 is also involved in colon cancer ^{[7] [9] [10]} and acute myeloid leukemia. ^[11]

References

1. GRCh38: Ensembl release 89: ENSG00000276365 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: MicroRNA 145" . Retrieved 2015-01-26.
4. Adammek M (2013). "MicroRNA miR-145 inhibits proliferation, invasiveness, and stem cell phenotype of an in vitro endometriosis model by targeting multiple cytoskeletal elements and pluripotency factors". Fertility and Sterility. 99 (5): 1346–1355.e5. doi: 10.1016/j.fertnstert.2012.11.055 . PMID   23312222.
5. Götte M, Mohr C, Koo CY, Stock C, Vaske AK, Viola M, et al. (Dec 2010). "miR-145-dependent targeting of junctional adhesion molecule A and modulation of fascin expression are associated with reduced breast cancer cell motility and invasiveness". Oncogene. 29 (50): 6569–6580. doi:10.1038/onc.2010.386. PMID   20818426. S2CID   11455884.
6. Larsson E, Fredlund Fuchs P, Heldin J, Barkefors I, Bondjers C, Genové G, et al. (Nov 2009). "Discovery of microvascular miRNAs using public gene expression data: miR-145 is expressed in pericytes and is a regulator of Fli1". Genome Medicine. 1 (11) 108. doi: 10.1186/gm108 . PMC   2808743 . PMID   19917099.
7. Zhang J, Guo H, Zhang H, Wang H, Qian G, Fan X, et al. (Jan 2011). "Putative tumor suppressor miR-145 inhibits colon cancer cell growth by targeting oncogene Friend leukemia virus integration 1 gene". Cancer. 117 (1): 86–95. doi:10.1002/cncr.25522. PMC   2995010 . PMID   20737575.
8. Sachdeva M, Zhu S, Wu F, Wu H, Walia V, Kumar S, et al. (Mar 2009). "p53 represses c-Myc through induction of the tumor suppressor miR-145". Proceedings of the National Academy of Sciences of the United States of America. 106 (9): 3207–3212. Bibcode:2009PNAS..106.3207S. doi: 10.1073/pnas.0808042106 . PMC   2651330 . PMID   19202062.
9. Slaby O, Svoboda M, Fabian P, Smerdova T, Knoflickova D, Bednarikova M, et al. (2007). "Altered expression of miR-21, miR-31, miR-143 and miR-145 is related to clinicopathologic features of colorectal cancer". Oncology. 72 (5–6): 397–402. doi:10.1159/000113489. PMID   18196926. S2CID   207615720.
10. Mazza T, Mazzoccoli G, Fusilli C, Capocefalo D, Panza A, Biagini T, et al. (2016-05-19). "Multifaceted enrichment analysis of RNA-RNA crosstalk reveals cooperating micro-societies in human colorectal cancer". Nucleic Acids Research. 44 (9): 4025–4036. doi:10.1093/nar/gkw245. ISSN   1362-4962. PMC   4872111 . PMID   27067546.
11. Starczynowski DT, Morin R, McPherson A, Lam J, Chari R, Wegrzyn J, et al. (Jan 2011). "Genome-wide identification of human microRNAs located in leukemia-associated genomic alterations". Blood. 117 (2): 595–607. doi: 10.1182/blood-2010-03-277012 . PMID   20962326.

Further reading

• Zhang J, Guo H, Qian G, Ge S, Ji H, Hu X, et al. (Aug 2010). "MiR-145, a new regulator of the DNA fragmentation factor-45 (DFF45)-mediated apoptotic network". Molecular Cancer. 9 211. doi: 10.1186/1476-4598-9-211 . PMC   2924312 . PMID   20687965.
• Zaman MS, Chen Y, Deng G, Shahryari V, Suh SO, Saini S, et al. (Jul 2010). "The functional significance of microRNA-145 in prostate cancer". British Journal of Cancer. 103 (2): 256–264. doi:10.1038/sj.bjc.6605742. PMC   2906737 . PMID   20588276.
• Sachdeva M, Mo YY (Mar 2010). "miR-145-mediated suppression of cell growth, invasion and metastasis". American Journal of Translational Research. 2 (2): 170–180. PMC   2855636 . PMID   20407606.
• Kano M, Seki N, Kikkawa N, Fujimura L, Hoshino I, Akutsu Y, et al. (Dec 2010). "miR-145, miR-133a and miR-133b: Tumor-suppressive miRNAs target FSCN1 in esophageal squamous cell carcinoma". International Journal of Cancer. 127 (12): 2804–2814. doi: 10.1002/ijc.25284 . PMID   21351259. S2CID   25480039.
• Chiyomaru T, Enokida H, Tatarano S, Kawahara K, Uchida Y, Nishiyama K, et al. (Mar 2010). "miR-145 and miR-133a function as tumour suppressors and directly regulate FSCN1 expression in bladder cancer". British Journal of Cancer. 102 (5): 883–891. doi:10.1038/sj.bjc.6605570. PMC   2833258 . PMID   20160723.
• Gregersen LH, Jacobsen AB, Frankel LB, Wen J, Krogh A, Lund AH (Jan 2010). Kudla G (ed.). "MicroRNA-145 targets YES and STAT1 in colon cancer cells". PLOS ONE. 5 (1): e8836. Bibcode:2010PLoSO...5.8836G. doi: 10.1371/journal.pone.0008836 . PMC   2809101 . PMID   20098684.
• Sachdeva M, Mo YY (Jan 2010). "MicroRNA-145 suppresses cell invasion and metastasis by directly targeting mucin 1". Cancer Research. 70 (1): 378–387. doi:10.1158/0008-5472.CAN-09-2021. PMC   2805032 . PMID   19996288.
• Larsson E, Fredlund Fuchs P, Heldin J, Barkefors I, Bondjers C, Genové G, et al. (Nov 2009). "Discovery of microvascular miRNAs using public gene expression data: miR-145 is expressed in pericytes and is a regulator of Fli1". Genome Medicine. 1 (11) 108. doi: 10.1186/gm108 . PMC   2808743 . PMID   19917099.
• Ostenfeld MS, Bramsen JB, Lamy P, Villadsen SB, Fristrup N, Sørensen KD, et al. (Feb 2010). "miR-145 induces caspase-dependent and -independent cell death in urothelial cancer cell lines with targeting of an expression signature present in Ta bladder tumors". Oncogene. 29 (7): 1073–1084. doi:10.1038/onc.2009.395. PMID   19915607. S2CID   25309570.
• Starczynowski DT, Kuchenbauer F, Argiropoulos B, Sung S, Morin R, Muranyi A, et al. (Jan 2010). "Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype". Nature Medicine. 16 (1): 49–58. doi:10.1038/nm.2054. PMID   19898489. S2CID   7987486.
• Arndt GM, Dossey L, Cullen LM, Lai A, Druker R, Eisbacher M, et al. (Oct 2009). "Characterization of global microRNA expression reveals oncogenic potential of miR-145 in metastatic colorectal cancer". BMC Cancer. 9 374. doi: 10.1186/1471-2407-9-374 . PMC   2770572 . PMID   19843336.
• Zhang C (Nov 2009). "MicroRNA-145 in vascular smooth muscle cell biology: a new therapeutic target for vascular disease". Cell Cycle. 8 (21). Georgetown, Tex.: 3469–3473. doi:10.4161/cc.8.21.9837. PMC   3593963 . PMID   19829088.
• Zeng L, Carter AD, Childs SJ (Oct 2009). "miR-145 directs intestinal maturation in zebrafish". Proceedings of the National Academy of Sciences of the United States of America. 106 (42): 17793–17798. Bibcode:2009PNAS..10617793Z. doi: 10.1073/pnas.0903693106 . PMC   2764920 . PMID   19805048.
• Spizzo R, Nicoloso MS, Lupini L, Lu Y, Fogarty J, Rossi S, et al. (Feb 2010). "miR-145 participates with TP53 in a death-promoting regulatory loop and targets estrogen receptor-alpha in human breast cancer cells". Cell Death and Differentiation. 17 (2): 246–254. doi:10.1038/cdd.2009.117. PMC   3648637 . PMID   19730444.
• Xin M, Small EM, Sutherland LB, Qi X, McAnally J, Plato CF, et al. (Sep 2009). "MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury". Genes & Development. 23 (18): 2166–2178. doi:10.1101/gad.1842409. PMC   2751981 . PMID   19720868.
• Cordes KR, Sheehy NT, White MP, Berry EC, Morton SU, Muth AN, et al. (Aug 2009). "miR-145 and miR-143 regulate smooth muscle cell fate and plasticity". Nature. 460 (7256): 705–710. Bibcode:2009Natur.460..705C. doi:10.1038/nature08195. PMC   2769203 . PMID   19578358.
• Cheng Y, Liu X, Yang J, Lin Y, Xu DZ, Lu Q, et al. (Jul 2009). "MicroRNA-145, a novel smooth muscle cell phenotypic marker and modulator, controls vascular neointimal lesion formation". Circulation Research. 105 (2): 158–166. doi:10.1161/CIRCRESAHA.109.197517. PMC   2728297 . PMID   19542014.
• Cho WC, Chow AS, Au JS (Aug 2009). "Restoration of tumour suppressor hsa-miR-145 inhibits cancer cell growth in lung adenocarcinoma patients with epidermal growth factor receptor mutation". European Journal of Cancer. 45 (12). Oxford, England: 2197–2206. doi:10.1016/j.ejca.2009.04.039. PMID   19493678.
• Chivukula RR, Mendell JT (May 2009). "Abate and switch: miR-145 in stem cell differentiation". Cell. 137 (4): 606–608. doi: 10.1016/j.cell.2009.04.059 . PMID   19450510.
• Xu N, Papagiannakopoulos T, Pan G, Thomson JA, Kosik KS (May 2009). "MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells". Cell. 137 (4): 647–658. doi: 10.1016/j.cell.2009.02.038 . PMID   19409607. S2CID   18601406.
• La Rocca G, Badin M, Shi B, Xu SQ, Deangelis T, Sepp-Lorenzinoi L, et al. (Aug 2009). "Mechanism of growth inhibition by MicroRNA 145: the role of the IGF-I receptor signaling pathway". Journal of Cellular Physiology. 220 (2): 485–491. doi:10.1002/jcp.21796. PMID   19391107. S2CID   44343336.
• Wang S, Bian C, Yang Z, Bo Y, Li J, Zeng L, et al. (May 2009). "miR-145 inhibits breast cancer cell growth through RTKN". International Journal of Oncology. 34 (5): 1461–1466. doi: 10.3892/ijo_00000275 . PMID   19360360.
• Zheng L, Pu J, Qi T, Qi M, Li D, Xiang X, et al. (Feb 2013). "miRNA-145 targets v-ets erythroblastosis virus E26 oncogene homolog 1 to suppress the invasion, metastasis, and angiogenesis of gastric cancer cells". Molecular Cancer Research : MCR. 11 (2): 182–193. doi: 10.1158/1541-7786.MCR-12-0534 . PMID   23233482.

External links

• Page for mir-145 microRNA precursor family at Rfam