Mir-196 microRNA precursor family

Last updated
mir-196 microRNA precursor family
RF00256.jpg
Predicted secondary structure and sequence conservation of mir-196
Identifiers
Symbolmir-196
Rfam RF00256
miRBase MI0000238
miRBase family MIPF0000031
Other data
RNA type Gene; miRNA
Domain Eukaryota
GO GO:0035195 GO:0035068
SO SO:0001244
PDB structures PDBe

miR-196 is a non-coding RNA called a microRNA that has been shown to be expressed in humans (MI0000238, MI0000279) and mice (MI0000552, MI0000553). [1] [2] miR-196 appears to be a vertebrate specific microRNA and has now been predicted or experimentally confirmed in a wide range of vertebrate species (MIPF0000031). In many species the miRNA appears to be expressed from intergenic regions in HOX gene clusters. The hairpin precursors are predicted based on base pairing and cross-species conservation—their extents are not known. In this case the mature sequence is excised from the 5' arm of the hairpin.

Contents

It has been suggested that a rare SNP (rs11614913) that overlaps hsa-mir-196a-2 has been found to be associated with non-small cell lung carcinoma. [3]

Further reading

References

  1. ↑ Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A, Tuschl T (2003). "New microRNAs from mouse and human". RNA. 9 (2): 175–9. doi:10.1261/rna.2146903. PMC   1370382 . PMID   12554859.
  2. ↑ Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP (2003). "Vertebrate microRNA genes". Science. 299 (5612): 1540. doi:10.1126/science.1080372. PMID   12624257. S2CID   37750545.
  3. ↑ Hu Z, Chen J, Tian T, Zhou X, Gu H, Xu L, Zeng Y, Miao R, Jin G, Ma H, Chen Y, Shen H (2008). "Genetic variants of miRNA sequences and non-small cell lung cancer survival". J Clin Invest. 118 (7): 2600–8. doi:10.1172/JCI34934. PMC   2402113 . PMID   18521189.
  4. ↑ Zhang XW, Pan SD, Feng YL, Liu JB, Dong J, Zhang YX, Chen JG, Hu ZB, Shen HB (2011). "[Relationship between genetic polymorphism in microRNAs precursor and genetic prediposition of hepatocellular carcinoma]". Zhonghua Yu Fang Yi Xue Za Zhi. 45 (3): 239–43. PMID   21624236.
  5. ↑ Georges M (2011). "The long and winding road from correlation to causation". Nat Genet. 43 (3): 180–1. doi:10.1038/ng0311-180. PMID   21350497. S2CID   205341688.
  6. ↑ Brest P, Lapaquette P, Souidi M, Lebrigand K, Cesaro A, Vouret-Craviari V, Mari B, Barbry P, Mosnier JF, Hébuterne X, Harel-Bellan A, Mograbi B, Darfeuille-Michaud A, Hofman P (2011). "A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease". Nat Genet. 43 (3): 242–5. doi:10.1038/ng.762. PMID   21278745. S2CID   11224420.
  7. ↑ Chen C, Zhang Y, Zhang L, Weakley SM, Yao Q (2011). "MicroRNA-196: critical roles and clinical applications in development and cancer". J Cell Mol Med. 15 (1): 14–23. doi:10.1111/j.1582-4934.2010.01219.x. PMC   3276076 . PMID   21091634.
  8. ↑ Scagnolari C, Zingariello P, Vecchiet J, Selvaggi C, Racciatti D, Taliani G, Riva E, Pizzigallo E, Antonelli G (2010). "Differential expression of interferon-induced microRNAs in patients with chronic hepatitis C virus infection treated with pegylated interferon alpha". Virol J. 7: 311. doi: 10.1186/1743-422X-7-311 . PMC   2996368 . PMID   21070682.
  9. ↑ Li Y, Zhang M, Chen H, Dong Z, Ganapathy V, Thangaraju M, Huang S (2010). "Ratio of miR-196s to HOXC8 messenger RNA correlates with breast cancer cell migration and metastasis". Cancer Res. 70 (20): 7894–904. doi:10.1158/0008-5472.CAN-10-1675. PMC   2955846 . PMID   20736365.
  10. ↑ Guan Y, Mizoguchi M, Yoshimoto K, Hata N, Shono T, Suzuki SO, Araki Y, Kuga D, Nakamizo A, Amano T, Ma X, Hayashi K, Sasaki T (2010). "MiRNA-196 is upregulated in glioblastoma but not in anaplastic astrocytoma and has prognostic significance". Clin Cancer Res. 16 (16): 4289–97. doi: 10.1158/1078-0432.CCR-10-0207 . PMID   20601442.
  11. ↑ Asli NS, Kessel M (2010). "Spatiotemporally restricted regulation of generic motor neuron programs by miR-196-mediated repression of Hoxb8". Dev Biol. 344 (2): 857–68. doi:10.1016/j.ydbio.2010.06.003. hdl: 11858/00-001M-0000-0011-F056-2 . PMID   20553899.
  12. ↑ Schotte D, Lange-Turenhout EA, Stumpel DJ, Stam RW, Buijs-Gladdines JG, Meijerink JP, Pieters R, Den Boer ML (2010). "Expression of miR-196b is not exclusively MLL-driven but is especially linked to activation of HOXA genes in pediatric acute lymphoblastic leukemia". Haematologica. 95 (10): 1675–82. doi:10.3324/haematol.2010.023481. PMC   2948092 . PMID   20494936.
  13. ↑ Hou W, Tian Q, Zheng J, Bonkovsky HL (2010). "MicroRNA-196 represses Bach1 protein and hepatitis C virus gene expression in human hepatoma cells expressing hepatitis C viral proteins". Hepatology. 51 (5): 1494–504. doi:10.1002/hep.23401. PMC   2862129 . PMID   20127796.
  14. ↑ McGlinn E, Yekta S, Mansfield JH, Soutschek J, Bartel DP, Tabin CJ (2009). "In ovo application of antagomiRs indicates a role for miR-196 in patterning the chick axial skeleton through Hox gene regulation". Proc Natl Acad Sci U S A. 106 (44): 18610–5. doi: 10.1073/pnas.0910374106 . PMC   2773993 . PMID   19846767.
  15. ↑ Sehm T, Sachse C, Frenzel C, Echeverri K (2009). "miR-196 is an essential early-stage regulator of tail regeneration, upstream of key spinal cord patterning events". Dev Biol. 334 (2): 468–80. doi: 10.1016/j.ydbio.2009.08.008 . PMID   19682983.
  16. ↑ Popovic R, Riesbeck LE, Velu CS, Chaubey A, Zhang J, Achille NJ, Erfurth FE, Eaton K, Lu J, Grimes HL, Chen J, Rowley JD, Zeleznik-Le NJ (2009). "Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization". Blood. 113 (14): 3314–22. doi:10.1182/blood-2008-04-154310. PMC   2665896 . PMID   19188669.
  17. ↑ Sonkoly E, Ståhle M, Pivarcsi A (2008). "MicroRNAs and immunity: novel players in the regulation of normal immune function and inflammation". Semin Cancer Biol. 18 (2): 131–40. doi:10.1016/j.semcancer.2008.01.005. PMID   18291670.
  18. ↑ Woltering JM, Durston AJ (2008). "MiR-10 represses HoxB1a and HoxB3a in zebrafish". PLOS ONE. 3 (1) e1396. doi: 10.1371/journal.pone.0001396 . PMC   2148072 . PMID   18167555.
  19. ↑ Richardson MK, Crooijmans RP, Groenen MA (2007). "Sequencing and genomic annotation of the chicken (Gallus gallus) Hox clusters, and mapping of evolutionarily conserved regions". Cytogenet Genome Res. 117 (1–4): 110–9. doi:10.1159/000103171. PMID   17675851. S2CID   2643703.
  20. ↑ Kawasaki H, Taira K (2004). "MicroRNA-196 inhibits HOXB8 expression in myeloid differentiation of HL60 cells". Nucleic Acids Symp Ser (Oxf). 48 (48): 211–2. doi: 10.1093/nass/48.1.211 . PMID   17150553.
  21. ↑ Chopra VS, Mishra RK (2006). ""Mir"acles in hox gene regulation". BioEssays. 28 (5): 445–8. doi: 10.1002/bies.20401 . PMID   16615131.
  22. ↑ Ronshaugen M, Biemar F, Piel J, Levine M, Lai EC (2005). "The Drosophila microRNA iab-4 causes a dominant homeotic transformation of halteres to wings". Genes Dev. 19 (24): 2947–52. doi:10.1101/gad.1372505. PMC   1315399 . PMID   16357215.
  23. ↑ Hornstein E, Mansfield JH, Yekta S, Hu JK, Harfe BD, McManus MT, Baskerville S, Bartel DP, Tabin CJ (2005). "The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development". Nature. 438 (7068): 671–4. doi:10.1038/nature04138. PMID   16319892. S2CID   2543608.
  24. ↑ Yekta S, Shih IH, Bartel DP (2004). "MicroRNA-directed cleavage of HOXB8 mRNA". Science. 304 (5670): 594–6. doi:10.1126/science.1097434. PMID   15105502. S2CID   20510339.


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