Mir-124 microRNA precursor family

Last updated
miR-124 microRNA precursor family
RF00239.jpg
Predicted secondary structure and sequence conservation of mir-124
Identifiers
Symbolmir-124
Rfam RF00239
miRBase MI0000443
miRBase family MIPF0000021
Other data
RNA type Gene; miRNA
Domain(s) Eukaryota
GO GO:0035195 GO:0035068
SO SO:0001244
PDB structures PDBe

The miR-124 microRNA precursor is a small non-coding RNA molecule that has been identified in flies (MI0000373), [1] nematode worms (MI0000302), [2] mouse (MI0000150) and human (MI0000443). [3] The mature ~21 nucleotide microRNAs are processed from hairpin precursor sequences by the Dicer enzyme, and in this case originates from the 3′ arm. miR-124 has been found to be the most abundant microRNA expressed in neuronal cells. Experiments to alter expression of miR-124 in neural cells did not appear to affect differentiation. [4] However these results are controversial since other reports have described a role for miR-124 during neuronal differentiation. [5] [6]

Contents

Targets of miR-124

Clinical medicine

Presence of the G allele, compared to the C allele, in SNP rs531564 in pri-miR-124-1, measured by PCR-RFLP in leukocyte DNA, is linked to a reduced risk of gastric cancer (e.g. GG v CC OR 0.34 95% CI 0.19-0.59, p<0.001). [10]

References

  1. ↑ Lai EC, Tomancak P, Williams RW, Rubin GM (2003). "Computational identification of Drosophila microRNA genes". Genome Biology. 4 (7): R42. doi: 10.1186/gb-2003-4-7-r42 . PMC   193629 . PMID   12844358.
  2. ↑ Lim LP, Lau NC, Weinstein EG, Abdelhakim A, Yekta S, Rhoades MW, et al. (April 2003). "The microRNAs of Caenorhabditis elegans". Genes & Development. 17 (8): 991–1008. doi:10.1101/gad.1074403. PMC   196042 . PMID   12672692.
  3. ↑ Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T (April 2002). "Identification of tissue-specific microRNAs from mouse". Current Biology. 12 (9): 735–739. doi:10.1016/S0960-9822(02)00809-6. hdl: 11858/00-001M-0000-0010-94EF-7 . PMID   12007417. S2CID   7901788.
  4. ↑ Cao X, Pfaff SL, Gage FH (March 2007). "A functional study of miR-124 in the developing neural tube". Genes & Development. 21 (5): 531–536. doi:10.1101/gad.1519207. PMC   1820895 . PMID   17344415.
  5. ↑ Yoo AS, Staahl BT, Chen L, Crabtree GR (July 2009). "MicroRNA-mediated switching of chromatin-remodelling complexes in neural development". Nature. 460 (7255): 642–646. Bibcode:2009Natur.460..642Y. doi:10.1038/nature08139. PMC   2921580 . PMID   19561591.
  6. ↑ Neo WH, Yap K, Lee SH, Looi LS, Khandelia P, Neo SX, et al. (July 2014). "MicroRNA miR-124 controls the choice between neuronal and astrocyte differentiation by fine-tuning Ezh2 expression". The Journal of Biological Chemistry. 289 (30): 20788–20801. doi: 10.1074/jbc.m113.525493 . PMC   4110287 . PMID   24878960.
  7. ↑ Visvanathan J, Lee S, Lee B, Lee JW, Lee SK (April 2007). "The microRNA miR-124 antagonizes the anti-neural REST/SCP1 pathway during embryonic CNS development". Genes & Development. 21 (7): 744–749. doi:10.1101/gad.1519107. PMC   1838526 . PMID   17403776.
  8. ↑ Makeyev EV, Zhang J, Carrasco MA, Maniatis T (August 2007). "The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing". Molecular Cell. 27 (3): 435–448. doi:10.1016/j.molcel.2007.07.015. PMC   3139456 . PMID   17679093.
  9. ↑ Arrant AE, Roberson ED (December 2014). "MicroRNA-124 modulates social behavior in frontotemporal dementia". Nature Medicine. 20 (12): 1381–1383. doi:10.1038/nm.3768. PMID   25473917. S2CID   1028320.
  10. ↑ Mirnoori SM, Shahangian SS, Salehi Z, Mashayekhi F, Talesh Sasani S, Saedi HS (October 2018). "Influence of single nucleotide polymorphisms in pri-miR-124-1 and STAT3 genes on gastric cancer susceptibility". British Journal of Biomedical Science. 75 (4): 182–186. doi:10.1080/09674845.2018.1492206. PMID   29938592. S2CID   49410250.
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