Mir-720 microRNA precursor family

In molecular biology, mir-720 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

Congenital neural tube defects

miR-720 expression has been found to vary in the serum levels of women carrying fetuses with and without neural tube defects. ^[1] miR-720 is significantly downregulated following child delivery, thus suggesting a role in pregnancy as well as a possible placental derivation.

Upregulation

miR-720 is upregulated in myelodysplastic syndromes, ^[2] in molar tooth germ in newborn mice following anti-miR-214 injection ^[3] and in mesangial cells (specialised smooth muscle cells in the kidneys) treated with microRNA inhibitor. ^[4]

Targeting

miR-720 was shown to target the pluripotency factor Nanog and to upregulate DNMTs. ^[5] miR-720 controlled stem cell phenotype, proliferation, and differentiation of human dental pulp cells. Dental pulp includes mesenchymal (stem) cells, blood vessels, blood and peripheral nerves. Repression of the pluripotency factor Nanog and upregulation of DNMTs in dental pulp cells by miR-720 initiated odontoblastic differentiation. Therefore, it was suggested that odontoblastic differentiation of dental pulp stem cells required miR-720 that repressed Nanog and induced Dnmt3a and Dnmt3b.

See also

• MicroRNA

References

1. Gu H, Li H, Zhang L, Luan H, Huang T, Wang L, et al. (2012). "Diagnostic role of microRNA expression profile in the serum of pregnant women with fetuses with neural tube defects". J Neurochem. 122 (3): 641–9. doi: 10.1111/j.1471-4159.2012.07812.x . PMID   22642222.
2. Borze I, Scheinin I, Siitonen S, Elonen E, Juvonen E, Knuutila S (2011). "miRNA expression profiles in myelodysplastic syndromes reveal Epstein-Barr virus miR-BART13 dysregulation". Leuk Lymphoma. 52 (8): 1567–73. doi:10.3109/10428194.2011.568652. PMID   21649547. S2CID   31148326.
3. Sehic A, Risnes S, Khuu C, Khan QE, Osmundsen H (2011). "Effects of in vivo transfection with anti-miR-214 on gene expression in murine molar tooth germ". Physiol Genomics. 43 (9): 488–98. doi:10.1152/physiolgenomics.00248.2010. PMID   21363966.
4. Chen YQ, Wang XX, Yao XM, Zhang DL, Yang XF, Tian SF, et al. (2012). "Abated microRNA-195 expression protected mesangial cells from apoptosis in early diabetic renal injury in mice". J Nephrol. 25 (4): 566–76. doi:10.5301/jn.5000034. PMID   21983986.
5. Hara, Emilio Satoshi; Ono, Mitsuaki; Eguchi, Takanori; Kubota, Satoshi; Pham, Hai Thanh; Sonoyama, Wataru; Tajima, Shoji; Takigawa, Masaharu; Calderwood, Stuart K. (2013-01-01). "miRNA-720 controls stem cell phenotype, proliferation and differentiation of human dental pulp cells". PLOS ONE. 8 (12) e83545. Bibcode:2013PLoSO...883545H. doi: 10.1371/journal.pone.0083545 . ISSN   1932-6203. PMC   3875457 . PMID   24386225.

Further reading

• Ragusa, M.; Statello, L.; Maugeri, M.; Majorana, A.; Barbagallo, D.; Salito, L.; Sammito, M.; Santonocito, M.; Angelica, R.; Cavallaro, A.; Scalia, M.; Caltabiano, R.; Privitera, G.; Biondi, A.; Di Vita, M.; Cappellani, A.; Vasquez, E.; Lanzafame, S.; Tendi, E.; Celeste, S.; Di Pietro, C.; Basile, F.; Purrello, M. (2012). "Specific alterations of the microRNA transcriptome and global network structure in colorectal cancer after treatment with MAPK/ERK inhibitors". Journal of Molecular Medicine. 90 (12): 1421–1438. doi:10.1007/s00109-012-0918-8. PMID   22660396. S2CID   12620912.
• Della Vittoria Scarpati, G.; Falcetta, F.; Carlomagno, C.; Ubezio, P.; Marchini, S.; De Stefano, A.; Singh, V. K.; d'Incalci, M.; De Placido, S.; Pepe, S. (2011). "A Specific miRNA Signature Correlates with Complete Pathological Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer". International Journal of Radiation Oncology, Biology, Physics. 83 (4): 1113–1119. doi:10.1016/j.ijrobp.2011.09.030. PMID   22172905.
• Chikh, A.; Matin, R. N. H.; Senatore, V.; Hufbauer, M.; Lavery, D.; Raimondi, C.; Ostano, P.; Mello-Grand, M.; Ghimenti, C.; Bahta, A.; Khalaf, S.; Akgül, B.; Braun, K. M.; Chiorino, G.; Philpott, M. P.; Harwood, C. A.; Bergamaschi, D. (2011). "IASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epithelia". The EMBO Journal. 30 (20): 4261–4273. doi:10.1038/emboj.2011.302. PMC   3199390 . PMID   21897369.
• Wenguang, Z.; Jianghong, W.; Jinquan, L.; Yashizawa, M. (2007). "A Subset of Skin-Expressed microRNAs with Possible Roles in Goat and Sheep Hair Growth Based on Expression Profiling of Mammalian microRNAs". OMICS: A Journal of Integrative Biology. 11 (4): 385–396. doi:10.1089/omi.2006.0031. PMID   18092910.