MIR141

MIR141
Identifiers
Aliases	MIR141 , MIRN141, mir-141, microRNA 141
External IDs	OMIM: 612093; GeneCards: MIR141; OMA:MIR141 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	6,964,191 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; olfactory zone of nasal mucosa; ; duodenum; ; gastrocnemius muscle; ; blood; ; islet of Langerhans; ; body of stomach; ; body of pancreas; ; fundus; ; endometrium;
	n/a
	More reference expression data
	n/a
Orthologs
	406933
	n/a
	ENSG00000207708
	n/a
	n ; a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

Last updated January 22, 2025

MicroRNA 141 is a non-coding RNA molecule that in humans is encoded by the MIR141 gene.^[3]

Function

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into an RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].

Related Research Articles

mir-9/mir-79 microRNA precursor family Precursor microRNA family

The miR-9 microRNA, is a short non-coding RNA gene involved in gene regulation. The mature ~21nt miRNAs are processed from hairpin precursor sequences by the Dicer enzyme. The dominant mature miRNA sequence is processed from the 5' arm of the mir-9 precursor, and from the 3' arm of the mir-79 precursor. The mature products are thought to have regulatory roles through complementarity to mRNA. In vertebrates, miR-9 is highly expressed in the brain, and is suggested to regulate neuronal differentiation. A number of specific targets of miR-9 have been proposed, including the transcription factor REST and its partner CoREST.

The miR-129 microRNA precursor is a small non-coding RNA molecule that regulates gene expression. This microRNA was first experimentally characterised in mouse and homologues have since been discovered in several other species, such as humans, rats and zebrafish. The mature sequence is excised by the Dicer enzyme from the 5' arm of the hairpin. It was elucidated by Calin et al. that miR-129-1 is located in a fragile site region of the human genome near a specific site, FRA7H in chromosome 7q32, which is a site commonly deleted in many cancers. miR-129-2 is located in 11p11.2.

mir-1 microRNA precursor family Type of RNA

The miR-1 microRNA precursor is a small micro RNA that regulates its target protein's expression in the cell. microRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give products at ~22 nucleotides. In this case the mature sequence comes from the 3' arm of the precursor. The mature products are thought to have regulatory roles through complementarity to mRNA. In humans there are two distinct microRNAs that share an identical mature sequence, and these are called miR-1-1 and miR-1-2.

Metastasis-associated protein MTA2 is a protein that in humans is encoded by the MTA2 gene.

In molecular biology, mir-221 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

In molecular biology mir-185 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

In molecular biology mir-708 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. miR-708 is located on chromosome 11q14.1 and is endcoded in intron 1 of the ODZ4 gene. It is most highly expressed in the brain and eyes, and has a supposed role in endoplasmic reticular stress of the eye.

MicroRNA 7-1 is a microRNA molecule that in humans is encoded by the MIR7-1 gene.

MicroRNA 196a-2 is a MicroRNA that in humans is encoded by the MIR196A2 gene, and is part of the Mir-196 microRNA precursor family.

MicroRNA 138-1 is a protein that in humans is encoded by the MIR138-1 gene.

MicroRNA 489 is a miRNA that in humans is encoded by the MIR489 gene.

MicroRNA 503 is a non-coding RNA molecule that in humans is encoded by the MIR503 gene.

MicroRNA 499a is a non-coding RNA that in humans is encoded by the MIR499A gene.

MicroRNA let-7f-2 is a protein that in humans is encoded by the MIRLET7F2 gene.

MicroRNA 106a is a microRNA that in humans is encoded by the MIR106A gene.

MicroRNA 495 is a protein that in humans is encoded by the MIR495 gene.

MicroRNA 375 is a non coding RNA that in humans is encoded by the MIR375 gene.

MicroRNA 195 is a microRNA that in humans is encoded by the MIR195 gene.

MicroRNA 124-3 is a protein that in humans is encoded by the MIR124-3 gene.

MicroRNA 517c is a protein that in humans is encoded by the MIR517C gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000207708 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: MicroRNA 141" . Retrieved 2018-03-23.

Du Y, Xu Y, Ding L, Yao H, Yu H, Zhou T, Si J (2009). "Down-regulation of miR-141 in gastric cancer and its involvement in cell growth". J. Gastroenterol. 44 (6): 556–61. doi:10.1007/s00535-009-0037-7. PMID 19363643. S2CID 22265968.
Hu M, Xia M, Chen X, Lin Z, Xu Y, Ma Y, Su L (August 2010). "MicroRNA-141 regulates Smad interacting protein 1 (SIP1) and inhibits migration and invasion of colorectal cancer cells". Dig. Dis. Sci. 55 (8): 2365–72. doi:10.1007/s10620-009-1008-9. PMID 19830559. S2CID 25368290.
Zhang L, Deng T, Li X, Liu H, Zhou H, Ma J, Wu M, Zhou M, Shen S, Li X, Niu Z, Zhang W, Shi L, Xiang B, Lu J, Wang L, Li D, Tang H, Li G (April 2010). "microRNA-141 is involved in a nasopharyngeal carcinoma-related genes network". Carcinogenesis. 31 (4): 559–66. doi: 10.1093/carcin/bgp335 . PMID 20053927.
Vrba L, Jensen TJ, Garbe JC, Heimark RL, Cress AE, Dickinson S, Stampfer MR, Futscher BW (January 2010). "Role for DNA methylation in the regulation of miR-200c and miR-141 expression in normal and cancer cells". PLOS ONE. 5 (1): e8697. Bibcode:2010PLoSO...5.8697V. doi: 10.1371/journal.pone.0008697 . PMC 2805718 . PMID 20084174.
Uhlmann S, Zhang JD, Schwäger A, Mannsperger H, Riazalhosseini Y, Burmester S, Ward A, Korf U, Wiemann S, Sahin O (July 2010). "miR-200bc/429 cluster targets PLCgamma1 and differentially regulates proliferation and EGF-driven invasion than miR-200a/141 in breast cancer". Oncogene. 29 (30): 4297–306. doi: 10.1038/onc.2010.201 . PMID 20514023.
Banaudha K, Kaliszewski M, Korolnek T, Florea L, Yeung ML, Jeang KT, Kumar A (January 2011). "MicroRNA silencing of tumor suppressor DLC-1 promotes efficient hepatitis C virus replication in primary human hepatocytes". Hepatology. 53 (1): 53–61. doi: 10.1002/hep.24016 . PMID 20967756.
Ho BC, Yu SL, Chen JJ, Chang SY, Yan BS, Hong QS, Singh S, Kao CL, Chen HY, Su KY, Li KC, Cheng CL, Cheng HW, Lee JY, Lee CN, Yang PC (January 2011). "Enterovirus-induced miR-141 contributes to shutoff of host protein translation by targeting the translation initiation factor eIF4E". Cell Host Microbe. 9 (1): 58–69. doi: 10.1016/j.chom.2010.12.001 . PMID 21238947.
Imanaka Y, Tsuchiya S, Sato F, Shimada Y, Shimizu K, Tsujimoto G (April 2011). "MicroRNA-141 confers resistance to cisplatin-induced apoptosis by targeting YAP1 in human esophageal squamous cell carcinoma". J. Hum. Genet. 56 (4): 270–6. doi: 10.1038/jhg.2011.1 . PMID 21289630.
Cheng H, Zhang L, Cogdell DE, Zheng H, Schetter AJ, Nykter M, Harris CC, Chen K, Hamilton SR, Zhang W (March 2011). "Circulating plasma MiR-141 is a novel biomarker for metastatic colon cancer and predicts poor prognosis". PLOS ONE. 6 (3): e17745. Bibcode:2011PLoSO...617745C. doi: 10.1371/journal.pone.0017745 . PMC 3060165 . PMID 21445232.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000207708 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: MicroRNA 141" . Retrieved 2018-03-23.

[1]

[2]

[3]

v t e miRNA precursor families
1-100	1 2 3 5 6 7 8/141/200 9/79 10 11 14 15 16 17 19 21 22 23 24 25 26 28 29 30 31 32 33 34 42 46/47/281 48 52 58 61 62 67 71 84 92 96
101-200	101 103/107 122 124 126 127 129 130 132 133 134 135 137 138 141 143 144 145 146 148/152 150 153 154 155 156 160 166 172 181 184 185 186 187 188 190 191 192/215 193 194 196 198 199 200
201-300	202 203 203a 205 208 210 212 214 216 218 219 221 223 224 241 275 277 278 279 281 282 296 299
301-400	301 305 322 326 330 331 337 338 339 340 344 345 346 350 351 361 363 365 367 370 374 383 384 390 394 395 396 397 398 399
401-500	403 408 423 425 430 431 432 433 434 444 448 449 451 452 454 455 474 484 488 489 491 492 497 498 500
501-600	503 504 505 506 529 535 541 542 544 548 549 550 552 558 562 569 572 575 580 584 589 590 592 598
601+	601 605 612 615 612 612 624 625 632 633 636 638 650 652 657 661 663 671 672 675 708 711 720 744 764 765 767 786 802 824 828 854 872 873 874 885 938 939 3180
Other	BART1 BART2 BHRF1-1 BHRF1-2 BHRF1-3 Let-7 Lin-4 Lsy-6

MIR141

Contents

Function

Related Research Articles

References

Further reading