MiR-155

pre-mir-155
pre-mir-155 secondary structure and sequence conservation.ard
Identifiers
Symbol	miR-155
Rfam	RF00731
miRBase family	MIPF0000157
Other data
RNA type	microRNA
Domain(s)	Eukaryota;
PDB structures	PDBe

MIR155
Identifiers
Aliases	MIR155 , MIRN155, miRNA155, mir-155, miR-155, microRNA 155
External IDs	OMIM: 609337 GeneCards: MIR155
Gene location (Human) Chr. Chromosome 21 (human) [1] Band 21q21.3 Start 25,573,980 bp [1] End 25,574,044 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in salivary gland blood hippocampus proper glomerulus male reproductive system prostate thyroid gland left lobe of thyroid gland left adrenal gland skin of abdomen n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 406947 n/a Ensembl ENSG00000283904 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 21: 25.57 – 25.57 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

MiR-155 is a microRNA that in humans is encoded by the MIR155 host gene or MIR155HG. ^[3] MiR-155 plays a role in various physiological and pathological processes. ^{[4] [5] [6] [7] [8] [9]} Exogenous molecular control in vivo of miR-155 expression may inhibit malignant growth, ^{[10] [11]} viral infections, ^[12] and enhance the progression of cardiovascular diseases. ^[13]

Discovery

The MIR155HG was initially identified as a gene that was transcriptionally activated by promoter insertion at a common retroviral integration site in B-cell lymphomas and was formerly called BIC (B-cell Integration Cluster). The MIR155HG is transcribed by RNA polymerase II and the resulting ~1,500 nucleotide RNA is capped and polyadenylated. The 23 nucleotide single-stranded miR-155, which is harbored in exon 3, is subsequently processed from the parent RNA molecule. ^[14]

Figure 1. Schematic representation of the MIR155HG (accession # NC_000021). This gene spans 13024 bp, is composed of three exons, and encodes a 1500 bp non-coding primary-miRNA (pri-miRNA) (accession # NR_001458). The location of the pre-mir-155 is denoted by the orange box.

Biogenesis

The MIR155HG RNA transcript does not contain a long open reading frame (ORF), however, it does include an imperfectly base-paired stem loop that is conserved across species. ^[15] This non-coding RNA (ncRNA) is now defined as a primary-miRNA (pri-miRNA). ^[15] Once miR-155 pri-miRNA is transcribed, this transcript is cleaved by the nuclear microprocessor complex, of which the core components are the RNase III type endonuclease Drosha and the DiGeorge critical region 8 (DGCR8) protein, ^{[16] [17]} to produce a 65 nucleotide stem-loop precursor miRNA (pre-mir-155) (see Figure 2).

Figure 2. The sequence of the pre-mir-155 stem loop that is matured from the pri-miRNA transcript. The mature miR-155 (miR-155-5p) sequence is shown in green and mature miR-155* (miR-155-3p) sequence is shown in red.

Following export from the nucleus by exportin-5, pre-mir-155 molecules are cleaved near the terminal loop by Dicer resulting in RNA duplexes of ~22nucleotides. ^{[16] [17]} Following Dicer cleavage, an Argonaute (Ago) protein binds to the short RNA duplexes, forming the core of a multi-subunit complex called the RNA-induced silencing complex (RISC). ^[18] In a manner similar to siRNA duplexes, one of the two strands, the "passenger miRNA" (miR-155*), is released and degraded while the other strand, designated the "guide strand" or "mature miRNA" (miR-155), is retained within the RISC. ^[18]

Recent data suggest that both arms of the pre-miRNA hairpin can give rise to mature miRNAs. ^{[19] [20]} Due to the increasing number of examples where two functional mature miRNAs are processed from opposite arms of the same pre-miRNA, pre-mir-155 products are now denoted with the suffix -5p (from the 5′ arm) (e.g. miR-155-5p) and -3p (from the 3′ arm) (e.g. miR-155-3p) following their name (see Figure 3). ^[21]

Figure 3. The mature miR-155 (miR-155-5p) sequence is shown in green and mature miR-155* (miR-155-3p) sequence is shown in red.

Once miR-155-5p/-3p is assembled into the RISC, these molecules subsequently recognize their target messenger RNA (mRNA) by base pairing interactions between nucleotides 2 and 8 of miR-155-5p/-3p (the seed region) and complementary nucleotides predominantly in the 3′-untranslated region (3′-UTR) of mRNAs (see Figure 4 and 5 below). ^[22] Finally, with the miR-155-5p/-3p acting as an adaptor for the RISC, complex-bound mRNAs are subjected to translational repression (i.e. inhibition of translation initiation) and/or degradation following deadenylation. ^[18]

Evolutionary conservation

Early phylogenetic analyses demonstrated that the sequence of pre-mir-155 and miR-155-5p was conserved between human, mouse, and chicken. ^[15] Recent annotated sequencing data found that 22 different organisms including, mammals, amphibians, birds, reptiles, sea squirts, and sea lampreys, express a conserved miR-155-5p. Currently much less sequence data is available regarding miR-155-3p, therefore, it is not clear how conserved this miRNA is across species.

Tissue distribution

Northern blot analysis found that miR-155 pri-miRNA was abundantly expressed in the human spleen and thymus and detectable in the liver, lung, and kidney. ^[15] Subsequently, polymerase chain reaction (PCR) experiments demonstrated that miR-155-5p was detectable in all human tissues investigated. ^[23] Sequence analysis of small RNA clone libraries comparing miRNA expression to all other organ systems examined established that miR-155-5p was one of five miRNAs (i.e. miR-142, miR-144, miR-150, miR-155, and miR-223) that was specific for hematopoietic cells including B-cells, T-cells, monocytes and granulocytes. ^[24] Together these results suggest that miR-155-5p is expressed in a number of tissues and cell types and, therefore, may play a critical role in a wide variety of biological processes, including hematopoiesis ^{[4] [5] [6]}

Although very few studies have investigated the expression levels of miR-155-3p, Landgraf et al. ^[24] established that expression levels of this miRNA was very low in hematopoietic cells. Additionally, PCR analyses found that while miR-155-3p was detectable in a number of human tissues the expression levels of this miRNA were 20–200 fold less when compared to miR-155-5p levels. ^[25] Even though the function of miR-155-3p has been largely ignored, several studies now suggest that, in some cases (astrocytes and plasmacytoid dendritic cells), both miR-155-5p and -3p can be functionally matured from pre-mir-155. ^{[26] [27]}

Targets

Bioinformatic analysis using TargetScan 6.2 (release date June, 2012) revealed at least 4,174 putative human miR-155-5p mRNA targets exist, with a total of 918 conserved sites (i.e. between mouse and human) and 4,249 poorly conserved sites (i.e. human only). [22] ^[28] Although the TargetScan 6.2 algorithm cannot be utilized to determine the miR-155-3p putative targets, one would speculate that this miRNA may also potentially regulate the expression of thousands of mRNA targets.

A comprehensive list of miR-155-5p/mRNA targets that were experimentally authenticated by both the demonstration of endogenous transcript regulation by miR-155-5p and validation of the miR-155-5p seed sequence through a reporter assay was recently assembled. ^[29] This list included 140 genes and included regulatory proteins for myelopoiesis and leukemogenesis (e.g. SHIP-1, AICDA, ETS1, JARID2, SPI1, etc.), inflammation (e.g. BACH1, FADD, IKBKE, INPP5D, MYD88, RIPK1, SPI1, SOCS, etc.) and known tumor suppressors (e.g. CEBPβ, IL17RB, PCCD4, TCF12, ZNF652, etc.). ^[29] The validated miR-155-5p binding site harbored in the SPI1 mRNA ^[30] and the validated miR-155-3p binding site harbored in the IRAK3 mRNA ^[27] are shown in Figures 4 and 5 respectively.

Figure 4. Complementary base-pairing between miR-155-5p and the human SPI1 (spleen focus forming virus proviral integration oncogene)(also known as PU.1) mRNA. The miR-155-5p binding site is located 46–53 base pairs downstream from the SPI1 mRNA stop codon. The requisite "seed sequence" base-pairing is denoted by the bold dashes.

Figure 5. Complementary base-pairing between miR-155-3p and the human IRAK3 (interleukin-1 receptor-associated kinase 3) mRNA. The miR-155-3p binding site is located 424–430 base pairs downstream from the IRAK3 mRNA stop codon. The requisite "seed sequence" base-pairing is denoted by the bold dashes.

Physiological roles

Hematopoiesis

Hematopoiesis is defined as the formation and development of blood cells, all of which are derived from hematopoietic stem-progenitor cells (HSPCs). ^[31] HSPCs are primitive cells capable of self-renewal and initially differentiate into common myeloid progenitor (CMP) or common lymphoid progenitor (CLP) cells. ^[31] CMPs represent the cellular population that has become myeloid lineage and it is the point that myelopoiesis begins. ^[31] During myelopoiesis further cellular differentiation takes place including thrombopoiesis, erythropoiesis, granulopoiesis, and monocytopoiesis. ^[31] CLPs subsequently differentiate into B-cells and T-cells in a process designated lymphopoiesis. ^[31] Given that miR-155-5p is expressed in hematopoietic cells ^[24] it was hypothesized that this miRNA plays a critical role in these cellular differentiation processes. In support of this premise, miR-155-5p was found to be expressed in CD34(+) human HSPCs, and it was speculated that this miRNA may hold these cells at an early stem-progenitor stage, inhibiting their differentiation into a more mature cell (i.e. megakaryocytic/erythroid/granulocytic/monocytic/B-lymphoid/T-lymphoid). ^[32] This hypothesis was substantiated when pre-mir-155 transduced HSPCs generated 5-fold fewer myeloid and 3-fold fewer erythroid colonies. ^[32] Additionally, Hu et al. ^[33] demonstrated that the homeobox protein, HOXA9, regulated MIR155HG expression in myeloid cells and that this miRNA played a functional role in hematopoiesis. These investigators found that forced expression of miR-155-5p in bone marrow cells resulted in a ~50% decrease in SPI1 (i.e. PU.1), ^[33] a transcription factor and a regulator of myelopoiesis, ^[34] and a validated target of this miRNA. ^[30] It was also established that in vitro differentiation of purified human erythroid progenitor cells resulted in a progressive decrease of miR-155-5p expression in mature red cells. ^[35] Additionally, mice deficient in pre-mir-155 showed clear defects in lymphocyte development and generation of B- and T-cell responses in vivo. ^{[30] [36] [37]} Finally, it was established that regulatory T-cell (Tregs) development required miR-155-5p and this miRNA was shown to play a role in Treg homeostasis and overall survival by directly targeting SOCS1, a negative regulator for IL-2 signaling. ^{[38] [39]} Taken together, these results strongly suggest that miR-155-5p is an essential molecule in the control of several aspects of hematopoiesis including myelopoiesis, erythropoiesis, and lymphopoiesis.

Immune system

The innate immune system constitutes the first line of defense against invading pathogens and is regarded as the major initiator of inflammatory responses. ^[40] Its cellular component involves primarily monocyte/macrophages, granulocytes, and dendritic cells (DCs), which are activated upon sensing of conserved pathogen structures (PAMPs) by pattern recognition receptors such as Toll-like receptors ((TLRs)). ^[41] MIR155HG (i.e. miR-155-5p) expression is greatly enhanced by TLR agonist stimulation of macrophages and dendritic cells. ^{[42] [43] [44] [45] [46] [47]} Since microbial lipopolysaccharide (an agonist of TLR4) activates a chain of events that lead to the stimulation of the NF-κB and AP-1 transcription factors, ^[41] it was hypothesized that endotoxin activation of MIR155HG may be mediated by those transcription factors. ^[42] Indeed, MIR155HG expression was found to be activated in LPS treated murine macrophage cells (i.e. Raw264.7) by an NF-κB-mediated mechanism. ^[43] Furthermore, H. pylori infection of primary murine bone marrow-derived macrophages resulted in a NF-κB dependent up-regulation of MIR155HG. ^[48] In the context of viral infection vesicular stomatitis virus (VSV) challenge of murine peritoneal macrophages was reported to result in miR-155-5p over-expression via a retinoic acid-inducible gene I/JNK/NF-κB–dependent pathway. ^[49] Support for a role of AP-1 in MIR155HG activation comes from studies using stimuli relevant to viral infection such as TLR3 ligand poly(I:C) or interferon beta (IFN-β). ^[44] Downstream of those stimuli AP-1 seems to play a major role in MIR155HG activation. ^{[44] [50] [51] [52]}

Upon its initiation via activation of e.g. TLRs by pathogen stimuli miR-155-5p functions as a post-transcriptional regulator of innate immune signaling pathways. Importantly, miR-155-5p displays a similar responsiveness to pathogen stimuli (e.g. TLR4 agonist LPS) as major pro-inflammatory marker mRNAs. ^[53] Once activated, miR-155-5p suppresses negative regulators of inflammation. These include inositol polyphosphate-5-phosphatase (INPP5D also denoted SHIP1) and suppressor of cytokine signaling 1 (SOCS1), suppression of which promotes cell survival, growth, migration, and anti-pathogen responses. ^{[49] [54] [55] [56]} Besides supporting the activation of defense pathways miR-155-5p may also limit the strength of the resulting NF-κB dependent inflammatory response, ^[53] suggesting varying functions of miR-155 at different stages of inflammation.

Taken together, these observations imply that the activation of the MIR155HG may be context-dependent given that both AP-1- and NF-κB-mediated mechanisms regulate the expression of this gene. These studies also suggest that a broad range of viral and bacterial inflammatory mediators can stimulate the expression of miR-155-5p and indicate that there is an intimate relationship between inflammation, innate immunity and MIR155HG expression.

Activity and phenotypes

There is evidence that miR-155 participates in cascades associated with cardiovascular diseases and hypertension, and was also found to be implicated in immunity, genomic instability, cell differentiation, inflammation, virus associated infections, cancer, and diabetes mellitus. ^[57]

Protective roles of miR-155 may arise in response to its action on silencing genes thereby regulating their expression time, mutations in miR-155 target site deny it the optimal access necessary to bring about gene silencing, leading to over abundance of delinquent activities that may go malignant, for example, miR-155 role as a protective agent against predisposition to B Cell associated malignancies is emphasized by maintaining the balance of Activation-Induced Cytidine Deaminase (AID) enzyme. MiR-155 mediates regulation of AID abundance and expression time upon immunological cues however, mutations in the target on AID mRNA result in its unresponsiveness to miR-155 silencing and lead to unbridled expression of its protein causing wild immature B-lymphocyte surges and AID-mediated chromosomal translocations. ^{[5] [6]}

Clinical significance

Cardiovascular

Transfection of miR-155 into human primary lung fibroblasts reduces the endogenous expression of the angiotensin II receptor AT1R protein. Furthermore, AT1R mediates angiotensin II-related elevation in blood pressure and contributes to the pathogenesis of heart failure. Defective miR-155 function could be implicated in hypertension and cardiovascular diseases if the cis-regulatory site on 3` UTR of AT1R (miR-155 target site) was affected due to a SNP polymorphism in AT1R itself. This mutation is disruptive of miR-155 targeting and thus preventive of AT1R expression down-regulation. ^[5] In low blood pressure over-expression of miR-155 correlates with the impairment of AT1R activity. ^[4]

Immunity

miR-155 is involved in immunity by playing key roles in modulating humoral and innate cell-mediated immune responses, for example, In miR-155 deficient mice, immunological-memory is impaired; making it fall prey to repetitive bouts of invasions by the same pathogen (Rodriguez et al. 2007), maturation and specificity of miR-155-deficient B-lymphocytes are impaired since the process relies on AID enzyme which has a miR-155 target in its 3′ UTR end. ^{[5] [6]} The phenotypic consequences involving deficiency of miR-155 in mice show later in life where the animals develop lung and intestinal lesions. ^[4]

Activated B and T cells show increased miR-155 expression, the same goes for macrophages and dendritic cells of the immune system. MiR-155 is crucial for proper lymphocyte development and maturation. Details of various manifestations of miR-155 levels and involvement in activities that ascertain optimal immune responses have been the subject of many researches:

Reduction of IgG1

Defective T and B cells as well as markedly decreased IgG1 responses were observed in miR-155-deficient mice, IgG1 is reduced whereas the expression of the IgM immunoglobulin remains normal in these mice. The change in IgG1 levels maybe explained by the fact that it is a target for miR-155 in B cells, the protein-encoding mRNA for the transcriptional regulator Pu.1-protein, elevation of Pu.1 protein predisposes defective IgG1 production. In addition to Pu.1, there are nearly 60 other differentially elevated genes in miR-155 deficient B cells, further inspection revealed possible miR-155 target sites in the 3′ UTR regions in these genes. ^[6]

Lymphocyte malignancies

Mature receptors affinity and specificity of lymphocytes to pathogenic agents underlie proper immune responses, optimal miR-155 coordination is required for manufacturing of normal B lymphocytes, production of high-affinity antibodies and balancing of BCR signalling. It has been demonstrated that miR-155 can be transferred through gap junctions from leukemic cells to healthy B cells and promote their transformation to tumorigenic-like cells ^[58]

Selection of competent B cells takes place in the germinal center where they are trained to differentiate body cells vs. foreign antigens, they compete for antigen recognition and for T cell help, in this fashion of selective pressure those B Cells that demonstrated high-affinity receptors and cooperation with T cells (affinity maturation) are recruited and deployed to the bone marrow or become memory B cells, apoptotic termination takes place for those B Cells failing the competition. Immature B cells which are miR-155 deficient evade apoptosis as a result of elevated Bcl-2 protein levels; a protein that was found to be involved in B Cell malignancies and to be controlled by miR-155. ^[6]

Inflammation

Inflammatory responses to triggers such as TNF-α involve macrophages with components that include miR-155. miR-155 is overexpressed in atopic dermatitis and contributes to chronic skin inflammation by increasing the proliferative response of T(H) cells through the downregulation of CTLA-4. ^[59] In Autoimmune disorders such as rheumatoid arthritis, miR-155 showed higher expression in patients' tissues and synovial fibroblasts. ^[4] In multiple sclerosis, increased expression of mir-155 has also been measured in peripheral and CNS-resident myeloid cells, including circulating blood monocytes and activated microglia. ^[60] It was also found that mir-155 is implicated in inflammation. Overexpression of mir-155 will lead to chronic inflammatory state in human. ^[61]

DNA viruses

In DNA viruses, miRNAs were experimentally verified, miRNAs in viruses are encoded by dsDNAs, ^[5] examples of such viruses include herpesviruses such as Humans-Epstein-Barr Virus (EBV) and adenoviruses, ^[4] another virus expressing miR-155-like miRNA in chickens is the oncogenic MDV-1 whose non-oncogenic relative MDV-2 does not, this suggests implication of miR-155 in lymphomagenesis. ^[5] Viruses can exploit host miRNAs to the degree that they use host miRNAs to encode for viral clones for example: miR-K12-11 in Kaposi's-sarcoma-associated Herpesvirus has a target specificity region orthologous to that of miR-155's; mimicking the action of miR-155 ^[62] and, sharing targets with it, thus it can be thought to suppress miR-155 accessibility to its targets by competition and this in effect downregulates expression of genes playing roles in cellular growth and apoptosis in a manner that defies regulations by miR-155. ^[4] EBV modulates host miR-155 expression, which is essential for growth of EBV-infected B cells. ^[63] EBV-infected cells have increased expression of miR-155 thereby disturbing equilibrium of expression for genes regulating transcription in those cells. ^{[4] [5]}

Cancer

Over-silencing by miR-155 may result in triggering oncogenic cascades that begin by apoptotic resistance, the pro-apoptotic Tumour Protein-53-induced-nuclear-protein1 (TP53INP1) is silenced by miR-155, over-expression of miR-155 leads to decreased levels of TP53INP1 in pancreatic ductal adenocarcinomas and possibly in other epithelial cancers where TP53INP1 activity is lost thereby resulting in apoptosis evasion and uncontrolled bouts of growth. ^[5]

Inactivation of DNA Mismatch Repair (MMR) as identified by elevation of mutation rates is the cause of Lynch Syndrome (LS), also known as hereditary nonpolyposis colorectal cancer (HNPCC), down-regulation of MMR controlling protein is carried out by over-expression of miR-155, MMR is controlled by a group of conserved proteins, reduced activity of these proteins results in elevated levels of mutations in the phenotype triggering a march towards developing this type of cancer. ^[64]

Other types of tumors in which miR-155 over-expression was reported include: thyroid carcinoma, breast cancer, colon cancer, cervical cancer, and lung cancer, where distinct miR-155 expression profiles quantification can potentially serve as signals for tumor detection and evaluation of prognosis outcome. ^[4] It is shown in an analysis that miR-155 expression is associated with survival in triple negative breast cancer. ^[65]

See also

• MicroRNA

References

1. GRCh38: Ensembl release 89: ENSG00000283904 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: MIR155HG".
4. Faraoni I, Antonetti FR, Cardone J, Bonmassar E (Jun 2009). "miR-155 gene: a typical multifunctional microRNA" (PDF). Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1792 (6): 497–505. doi: 10.1016/j.bbadis.2009.02.013 . PMID   19268705.
5. Teng G, Papavasiliou FN (Mar 2009). "Shhh! Silencing by microRNA-155". Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 364 (1517): 631–637. doi:10.1098/rstb.2008.0209. PMC   2660923 . PMID   19008191.
6. Calame K (Dec 2007). "MicroRNA-155 function in B Cells". Immunity. 27 (6): 825–827. doi: 10.1016/j.immuni.2007.11.010 . PMID   18093533.
7. Tili E, Croce CM, Michaille JJ (2009). "miR-155: on the crosstalk between inflammation and cancer". International Reviews of Immunology. 28 (5): 264–284. doi:10.1080/08830180903093796. PMID   19811312. S2CID   205589961.
8. O'Connell RM, Rao DS, Baltimore D (2012). "microRNA regulation of inflammatory responses". Annual Review of Immunology. 30: 295–312. doi:10.1146/annurev-immunol-020711-075013. PMID   22224773.
9. Elton TS, Selemon H, Elton SM, Parinandi NL (Dec 2013). "Regulation of the MIR155 host gene in physiological and pathological processes". Gene. 532 (1): 1–12. doi:10.1016/j.gene.2012.12.009. PMID   23246696.
10. Mattiske S, Suetani RJ, Neilsen PM, Callen DF (Aug 2012). "The oncogenic role of miR-155 in breast cancer". Cancer Epidemiology, Biomarkers & Prevention. 21 (8): 1236–1243. doi: 10.1158/1055-9965.EPI-12-0173 . hdl: 2440/73553 . PMID   22736789.
11. Babar IA, Cheng CJ, Booth CJ, Liang X, Weidhaas JB, Saltzman WM, Slack FJ (Jun 2012). "Nanoparticle-based therapy in an in vivo microRNA-155 (miR-155)-dependent mouse model of lymphoma". Proceedings of the National Academy of Sciences of the United States of America. 109 (26): E1695–1704. doi: 10.1073/pnas.1201516109 . PMC   3387084 . PMID   22685206.
12. Wang L, Toomey NL, Diaz LA, Walker G, Ramos JC, Barber GN, Ning S (Aug 2011). "Oncogenic IRFs provide a survival advantage for Epstein-Barr virus- or human T-cell leukemia virus type 1-transformed cells through induction of BIC expression". Journal of Virology. 85 (16): 8328–8337. doi:10.1128/JVI.00570-11. PMC   3147954 . PMID   21680528.
13. Corsten MF, Papageorgiou A, Verhesen W, Carai P, Lindow M, Obad S, Summer G, Coort SL, Hazebroek M, van Leeuwen R, Gijbels MJ, Wijnands E, Biessen EA, De Winther MP, Stassen FR, Carmeliet P, Kauppinen S, Schroen B, Heymans S (Aug 2012). "MicroRNA profiling identifies microRNA-155 as an adverse mediator of cardiac injury and dysfunction during acute viral myocarditis". Circulation Research. 111 (4): 415–425. doi: 10.1161/CIRCRESAHA.112.267443 . PMID   22715471.
14. Eis PS, Tam W, Sun L, Chadburn A, Li Z, Gomez MF, Lund E, Dahlberg JE (Mar 2005). "Accumulation of miR-155 and BIC RNA in human B cell lymphomas". Proceedings of the National Academy of Sciences of the United States of America. 102 (10): 3627–3632. Bibcode:2005PNAS..102.3627E. doi: 10.1073/pnas.0500613102 . PMC   552785 . PMID   15738415.
15. Tam W (Aug 2001). "Identification and characterization of human BIC, a gene on chromosome 21 that encodes a noncoding RNA". Gene. 274 (1–2): 157–167. doi:10.1016/S0378-1119(01)00612-6. PMID   11675008.
16. Kim VN, Han J, Siomi MC (Feb 2009). "Biogenesis of small RNAs in animals". Nature Reviews Molecular Cell Biology. 10 (2): 126–139. doi:10.1038/nrm2632. PMID   19165215. S2CID   8360619.
17. Krol J, Loedige I, Filipowicz W (Sep 2010). "The widespread regulation of microRNA biogenesis, function and decay". Nature Reviews Genetics. 11 (9): 597–610. doi:10.1038/nrg2843. PMID   20661255. S2CID   2619579.
18. Fabian MR, Sonenberg N (Jun 2012). "The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC". Nature Structural & Molecular Biology. 19 (6): 586–593. doi:10.1038/nsmb.2296. PMID   22664986. S2CID   13176647.
19. Bushati N, Cohen SM (2007). "microRNA functions". Annual Review of Cell and Developmental Biology. 23: 175–205. doi:10.1146/annurev.cellbio.23.090506.123406. PMID   17506695.
20. Filipowicz W, Bhattacharyya SN, Sonenberg N (Feb 2008). "Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?". Nature Reviews Genetics. 9 (2): 102–114. doi:10.1038/nrg2290. PMID   18197166. S2CID   11824239.
21. Griffiths-Jones S (Jan 2004). "The microRNA Registry". Nucleic Acids Research. 32 (Database issue): D109–11. doi:10.1093/nar/gkh023. PMC   308757 . PMID   14681370.
22. Friedman RC, Farh KK, Burge CB, Bartel DP (Jan 2009). "Most mammalian mRNAs are conserved targets of microRNAs". Genome Research. 19 (1): 92–105. doi:10.1101/gr.082701.108. PMC   2612969 . PMID   18955434.
23. Martin MM, Lee EJ, Buckenberger JA, Schmittgen TD, Elton TS (Jul 2006). "MicroRNA-155 regulates human angiotensin II type 1 receptor expression in fibroblasts". The Journal of Biological Chemistry. 281 (27): 18277–18284. doi: 10.1074/jbc.M601496200 . PMC   3567671 . PMID   16675453.
24. Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foà R, Schliwka J, Fuchs U, Novosel A, Müller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M, Weir DB, Choksi R, De Vita G, Frezzetti D, Trompeter HI, Hornung V, Teng G, Hartmann G, Palkovits M, Di Lauro R, Wernet P, Macino G, Rogler CE, Nagle JW, Ju J, Papavasiliou FN, Benzing T, Lichter P, Tam W, Brownstein MJ, Bosio A, Borkhardt A, Russo JJ, Sander C, Zavolan M, Tuschl T (Jun 2007). "A mammalian microRNA expression atlas based on small RNA library sequencing". Cell. 129 (7): 1401–1414. doi:10.1016/j.cell.2007.04.040. PMC   2681231 . PMID   17604727.
25. Elton TS, Sansom SE, Martin MM (2010). "Trisomy-21 gene dosage over-expression of miRNAs results in the haploinsufficiency of specific target proteins". RNA Biology. 7 (5): 540–547. doi:10.4161/rna.7.5.12685. PMC   3073250 . PMID   21081842.
26. Tarassishin L, Loudig O, Bauman A, Shafit-Zagardo B, Suh HS, Lee SC (Dec 2011). "Interferon regulatory factor 3 inhibits astrocyte inflammatory gene expression through suppression of the proinflammatory miR-155 and miR-155*". Glia. 59 (12): 1911–1922. doi:10.1002/glia.21233. PMC   3241213 . PMID   22170100.
27. Zhou H, Huang X, Cui H, Luo X, Tang Y, Chen S, Wu L, Shen N (Dec 2010). "miR-155 and its star-form partner miR-155* cooperatively regulate type I interferon production by human plasmacytoid dendritic cells". Blood. 116 (26): 5885–5894. doi: 10.1182/blood-2010-04-280156 . PMID   20852130.
28. Lewis BP, Burge CB, Bartel DP (Jan 2005). "Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets". Cell. 120 (1): 15–20. doi: 10.1016/j.cell.2004.12.035 . PMID   15652477. S2CID   17316349.
29. Neilsen PM, Noll JE, Mattiske S, Bracken CP, Gregory PA, Schulz RB, Lim SP, Kumar R, Suetani RJ, Goodall GJ, Callen DF (Jun 2013). "Mutant p53 drives invasion in breast tumors through up-regulation of miR-155". Oncogene. 32 (24): 2992–3000. doi: 10.1038/onc.2012.305 . hdl: 2440/76596 . PMID   22797073.
30. Vigorito E, Perks KL, Abreu-Goodger C, Bunting S, Xiang Z, Kohlhaas S, Das PP, Miska EA, Rodriguez A, Bradley A, Smith KG, Rada C, Enright AJ, Toellner KM, Maclennan IC, Turner M (Dec 2007). "microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells". Immunity. 27 (6): 847–859. doi:10.1016/j.immuni.2007.10.009. PMC   4135426 . PMID   18055230.
31. Mayani H (Mar 2010). "Biological differences between neonatal and adult human hematopoietic stem/progenitor cells". Stem Cells and Development. 19 (3): 285–298. doi:10.1089/scd.2009.0327. PMID   19778207.
32. Georgantas RW, Hildreth R, Morisot S, Alder J, Liu CG, Heimfeld S, Calin GA, Croce CM, Civin CI (Feb 2007). "CD34+ hematopoietic stem-progenitor cell microRNA expression and function: a circuit diagram of differentiation control". Proceedings of the National Academy of Sciences of the United States of America. 104 (8): 2750–2755. Bibcode:2007PNAS..104.2750G. doi: 10.1073/pnas.0610983104 . PMC   1796783 . PMID   17293455.
33. Hu YL, Fong S, Largman C, Shen WF (Sep 2010). "HOXA9 regulates miR-155 in hematopoietic cells". Nucleic Acids Research. 38 (16): 5472–5478. doi:10.1093/nar/gkq337. PMC   2938212 . PMID   20444872.
34. Kastner P, Chan S (2008). "PU.1: a crucial and versatile player in hematopoiesis and leukemia". The International Journal of Biochemistry & Cell Biology. 40 (1): 22–27. doi:10.1016/j.biocel.2007.01.026. PMID   17374502.
35. Masaki S, Ohtsuka R, Abe Y, Muta K, Umemura T (Dec 2007). "Expression patterns of microRNAs 155 and 451 during normal human erythropoiesis". Biochemical and Biophysical Research Communications. 364 (3): 509–514. doi:10.1016/j.bbrc.2007.10.077. PMID   17964546.
36. Rodriguez A, Vigorito E, Clare S, Warren MV, Couttet P, Soond DR, van Dongen S, Grocock RJ, Das PP, Miska EA, Vetrie D, Okkenhaug K, Enright AJ, Dougan G, Turner M, Bradley A (Apr 2007). "Requirement of bic/microRNA-155 for normal immune function". Science. 316 (5824): 608–611. Bibcode:2007Sci...316..608R. doi:10.1126/science.1139253. PMC   2610435 . PMID   17463290.
37. Thai TH, Calado DP, Casola S, Ansel KM, Xiao C, Xue Y, Murphy A, Frendewey D, Valenzuela D, Kutok JL, Schmidt-Supprian M, Rajewsky N, Yancopoulos G, Rao A, Rajewsky K (Apr 2007). "Regulation of the germinal center response by microRNA-155". Science. 316 (5824): 604–608. Bibcode:2007Sci...316..604T. doi:10.1126/science.1141229. PMID   17463289. S2CID   8174458.
38. Kohlhaas S, Garden OA, Scudamore C, Turner M, Okkenhaug K, Vigorito E (Mar 2009). "Cutting edge: the Foxp3 target miR-155 contributes to the development of regulatory T cells". Journal of Immunology. 182 (5): 2578–2582. doi: 10.4049/jimmunol.0803162 . PMID   19234151.
39. Lu LF, Thai TH, Calado DP, Chaudhry A, Kubo M, Tanaka K, Loeb GB, Lee H, Yoshimura A, Rajewsky K, Rudensky AY (Jan 2009). "Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein". Immunity. 30 (1): 80–91. doi:10.1016/j.immuni.2008.11.010. PMC   2654249 . PMID   19144316.
40. Medzhitov R (Mar 2010). "Inflammation 2010: new adventures of an old flame". Cell. 140 (6): 771–776. doi: 10.1016/j.cell.2010.03.006 . PMID   20303867. S2CID   10297400.
41. Takeda K, Akira S (Jan 2005). "Toll-like receptors in innate immunity". International Immunology. 17 (1): 1–14. doi:10.1093/intimm/dxh186. PMID   15585605.
42. Taganov KD, Boldin MP, Chang KJ, Baltimore D (Aug 2006). "NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses". Proceedings of the National Academy of Sciences of the United States of America. 103 (33): 12481–12486. Bibcode:2006PNAS..10312481T. doi: 10.1073/pnas.0605298103 . PMC   1567904 . PMID   16885212.
43. Tili E, Michaille JJ, Cimino A, Costinean S, Dumitru CD, Adair B, Fabbri M, Alder H, Liu CG, Calin GA, Croce CM (Oct 2007). "Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock". Journal of Immunology. 179 (8): 5082–5089. doi: 10.4049/jimmunol.179.8.5082 . PMID   17911593.
44. O'Connell RM, Taganov KD, Boldin MP, Cheng G, Baltimore D (Jan 2007). "MicroRNA-155 is induced during the macrophage inflammatory response". Proceedings of the National Academy of Sciences of the United States of America. 104 (5): 1604–1609. Bibcode:2007PNAS..104.1604O. doi: 10.1073/pnas.0610731104 . PMC   1780072 . PMID   17242365.
45. Ceppi M, Pereira PM, Dunand-Sauthier I, Barras E, Reith W, Santos MA, Pierre P (Feb 2009). "MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells". Proceedings of the National Academy of Sciences of the United States of America. 106 (8): 2735–2740. Bibcode:2009PNAS..106.2735C. doi: 10.1073/pnas.0811073106 . PMC   2650335 . PMID   19193853.
46. Cremer TJ, Ravneberg DH, Clay CD, Piper-Hunter MG, Marsh CB, Elton TS, Gunn JS, Amer A, Kanneganti TD, Schlesinger LS, Butchar JP, Tridandapani S (2009). "MiR-155 induction by F. novicida but not the virulent F. tularensis results in SHIP down-regulation and enhanced pro-inflammatory cytokine response". PLOS ONE. 4 (12): e8508. Bibcode:2009PLoSO...4.8508C. doi: 10.1371/journal.pone.0008508 . PMC   2794384 . PMID   20041145.
47. Mao CP, He L, Tsai YC, Peng S, Kang TH, Pang X, Monie A, Hung CF, Wu TC (2011). "In vivo microRNA-155 expression influences antigen-specific T cell-mediated immune responses generated by DNA vaccination". Cell & Bioscience. 1 (1): 3. doi: 10.1186/2045-3701-1-3 . PMC   3116247 . PMID   21711593.
48. Koch M, Mollenkopf HJ, Klemm U, Meyer TF (May 2012). "Induction of microRNA-155 is TLR- and type IV secretion system-dependent in macrophages and inhibits DNA-damage induced apoptosis". Proceedings of the National Academy of Sciences of the United States of America. 109 (19): E1153–1162. doi: 10.1073/pnas.1116125109 . PMC   3358876 . PMID   22509021.
49. Wang P, Hou J, Lin L, Wang C, Liu X, Li D, Ma F, Wang Z, Cao X (Nov 2010). "Inducible microRNA-155 feedback promotes type I IFN signaling in antiviral innate immunity by targeting suppressor of cytokine signaling 1". Journal of Immunology. 185 (10): 6226–6233. doi: 10.4049/jimmunol.1000491 . PMID   20937844.
50. Tili E, Michaille JJ, Adair B, Alder H, Limagne E, Taccioli C, Ferracin M, Delmas D, Latruffe N, Croce CM (Sep 2010). "Resveratrol decreases the levels of miR-155 by upregulating miR-663, a microRNA targeting JunB and JunD". Carcinogenesis. 31 (9): 1561–1566. doi:10.1093/carcin/bgq143. PMC   4647642 . PMID   20622002.
51. McCoy CE, Sheedy FJ, Qualls JE, Doyle SL, Quinn SR, Murray PJ, O'Neill LA (Jul 2010). "IL-10 inhibits miR-155 induction by toll-like receptors". The Journal of Biological Chemistry. 285 (27): 20492–20498. doi: 10.1074/jbc.M110.102111 . PMC   2898307 . PMID   20435894.
52. Ruggiero T, Trabucchi M, De Santa F, Zupo S, Harfe BD, McManus MT, Rosenfeld MG, Briata P, Gherzi R (Sep 2009). "LPS induces KH-type splicing regulatory protein-dependent processing of microRNA-155 precursors in macrophages". FASEB Journal. 23 (9): 2898–2908. doi:10.1096/fj.09-131342. PMID   19423639. S2CID   588328.
53. Schulte LN, Westermann AJ, Vogel J (Jan 2013). "Differential activation and functional specialization of miR-146 and miR-155 in innate immune sensing". Nucleic Acids Research. 41 (1): 542–553. doi:10.1093/nar/gks1030. PMC   3592429 . PMID   23143100.
54. Androulidaki A, Iliopoulos D, Arranz A, Doxaki C, Schworer S, Zacharioudaki V, Margioris AN, Tsichlis PN, Tsatsanis C (Aug 2009). "The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs". Immunity. 31 (2): 220–231. doi:10.1016/j.immuni.2009.06.024. PMC   2865583 . PMID   19699171.
55. O'Connell RM, Chaudhuri AA, Rao DS, Baltimore D (Apr 2009). "Inositol phosphatase SHIP1 is a primary target of miR-155". Proceedings of the National Academy of Sciences of the United States of America. 106 (17): 7113–7118. Bibcode:2009PNAS..106.7113O. doi: 10.1073/pnas.0902636106 . PMC   2678424 . PMID   19359473.
56. Costinean S, Sandhu SK, Pedersen IM, Tili E, Trotta R, Perrotti D, Ciarlariello D, Neviani P, Harb J, Kauffman LR, Shidham A, Croce CM (Aug 2009). "Src homology 2 domain-containing inositol-5-phosphatase and CCAAT enhancer-binding protein beta are targeted by miR-155 in B cells of Emicro-MiR-155 transgenic mice". Blood. 114 (7): 1374–1382. doi:10.1182/blood-2009-05-220814. PMC   2727407 . PMID   19520806.
57. Jankauskas SS, Gambardella J, Sardu C, Lombardi A, Santulli G (July 2021). "Functional Role of miR-155 in the Pathogenesis of Diabetes Mellitus and Its Complications". Non-Coding RNA. 7 (3): 39. doi: 10.3390/ncrna7030039 . PMC   8293470 . PMID   34287359.
58. Nesmiyanov P, Strygin A, Tolkachev B, Kaplanov K, Dotsenko A, Strygina A (2016). "mIRNA-155 shuttling through gap junctions facilitates CLL progression". The 14th CIMT Annual Meeting Mechanisms of Efficacy in Cancer Immunotherapy, Mainz, Germany, 2016.
59. Sonkoly E, Janson P, Majuri ML, Savinko T, Fyhrquist N, Eidsmo L, Xu N, Meisgen F, Wei T, Bradley M, Stenvang J, Kauppinen S, Alenius H, Lauerma A, Homey B, Winqvist O, Ståhle M, Pivarcsi A (Sep 2010). "MiR-155 is overexpressed in patients with atopic dermatitis and modulates T-cell proliferative responses by targeting cytotoxic T lymphocyte-associated antigen 4". The Journal of Allergy and Clinical Immunology. 126 (3): 581–589.e1–20. doi:10.1016/j.jaci.2010.05.045. PMID   20673989.
60. Moore CS, Rao VT, Durafourt BA, Bedell BJ, Ludwin SK, Bar-Or A, Antel JP (Nov 2013). "miR-155 as a multiple sclerosis-relevant regulator of myeloid cell polarization". Annals of Neurology. 74 (5): 709–720. doi: 10.1002/ana.23967 . PMID   23818336. S2CID   205344718.
61. O'Connell RM, Rao DS, Baltimore D (2012). "microRNA regulation of inflammatory responses". Annual Review of Immunology. 30: 295–312. doi:10.1146/annurev-immunol-020711-075013. PMID   22224773.
62. Skalsky RL, Samols MA, Plaisance KB, Boss IW, Riva A, Lopez MC, Baker HV, Renne R (Dec 2007). "Kaposi's sarcoma-associated herpesvirus encodes an ortholog of miR-155". Journal of Virology. 81 (23): 12836–12845. doi:10.1128/JVI.01804-07. PMC   2169101 . PMID   17881434.
63. Linnstaedt SD, Gottwein E, Skalsky RL, Luftig MA, Cullen BR (Nov 2010). "Virally induced cellular microRNA miR-155 plays a key role in B-cell immortalization by Epstein-Barr virus". Journal of Virology. 84 (22): 11670–11678. doi:10.1128/JVI.01248-10. PMC   2977875 . PMID   20844043.
64. Valeri N, Gasparini P, Fabbri M, Braconi C, Veronese A, Lovat F, Adair B, Vannini I, Fanini F, Bottoni A, Costinean S, Sandhu SK, Nuovo GJ, Alder H, Gafa R, Calore F, Ferracin M, Lanza G, Volinia S, Negrini M, McIlhatton MA, Amadori D, Fishel R, Croce CM (Apr 2010). "Modulation of mismatch repair and genomic stability by miR-155". Proceedings of the National Academy of Sciences of the United States of America. 107 (15): 6982–6987. Bibcode:2010PNAS..107.6982V. doi: 10.1073/pnas.1002472107 . PMC   2872463 . PMID   20351277.
65. Lánczky A, Nagy Á, Bottai G, Munkácsy G, Szabó A, Santarpia L, Győrffy B (2016-12-01). "miRpower: a web-tool to validate survival-associated miRNAs utilizing expression data from 2178 breast cancer patients". Breast Cancer Research and Treatment. 160 (3): 439–446. doi:10.1007/s10549-016-4013-7. ISSN   1573-7217. PMID   27744485. S2CID   11165696.

Further reading

• Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z (Jul 2005). "Identification of hundreds of conserved and nonconserved human microRNAs". Nature Genetics. 37 (7): 766–770. doi:10.1038/ng1590. PMID   15965474. S2CID   7746954.
• Huang RS, Hu GQ, Lin B, Lin ZY, Sun CC (Dec 2010). "MicroRNA-155 silencing enhances inflammatory response and lipid uptake in oxidized low-density lipoprotein-stimulated human THP-1 macrophages". Journal of Investigative Medicine. 58 (8): 961–967. doi:10.2310/jim.0b013e3181ff46d7. PMID   21030878. S2CID   83123221.
• Ceolotto G, Papparella I, Bortoluzzi A, Strapazzon G, Ragazzo F, Bratti P, Fabricio AS, Squarcina E, Gion M, Palatini P, Semplicini A (Feb 2011). "Interplay between miR-155, AT1R A1166C polymorphism, and AT1R expression in young untreated hypertensives". American Journal of Hypertension. 24 (2): 241–246. doi: 10.1038/ajh.2010.211 . PMID   20966899.
• Wang G, Tam LS, Li EK, Kwan BC, Chow KM, Luk CC, Li PK, Szeto CC (Dec 2010). "Serum and urinary cell-free MiR-146a and MiR-155 in patients with systemic lupus erythematosus". The Journal of Rheumatology. 37 (12): 2516–2522. doi: 10.3899/jrheum.100308 . PMID   20952466. S2CID   23208771.
• Kutty RK, Nagineni CN, Samuel W, Vijayasarathy C, Hooks JJ, Redmond TM (Nov 2010). "Inflammatory cytokines regulate microRNA-155 expression in human retinal pigment epithelial cells by activating JAK/STAT pathway". Biochemical and Biophysical Research Communications. 402 (2): 390–395. doi:10.1016/j.bbrc.2010.10.042. PMC   2992362 . PMID   20950585.
• Imaizumi T, Tanaka H, Tajima A, Yokono Y, Matsumiya T, Yoshida H, Tsuruga K, Aizawa-Yashiro T, Hayakari R, Inoue I, Ito E, Satoh K (2010). "IFN-γ and TNF-α synergistically induce microRNA-155 which regulates TAB2/IP-10 expression in human mesangial cells". American Journal of Nephrology. 32 (5): 462–468. doi:10.1159/000321365. PMID   20948191. S2CID   12859943.
• Thompson RC, Herscovitch M, Zhao I, Ford TJ, Gilmore TD (Jan 2011). "NF-kappaB down-regulates expression of the B-lymphoma marker CD10 through a miR-155/PU.1 pathway". The Journal of Biological Chemistry. 286 (3): 1675–1682. doi: 10.1074/jbc.M110.177063 . PMC   3023462 . PMID   20947507.
• Wang P, Hou J, Lin L, Wang C, Liu X, Li D, Ma F, Wang Z, Cao X (Nov 2010). "Inducible microRNA-155 feedback promotes type I IFN signaling in antiviral innate immunity by targeting suppressor of cytokine signaling 1". Journal of Immunology. 185 (10): 6226–6233. doi: 10.4049/jimmunol.1000491 . PMID   20937844.
• O'Connell RM, Kahn D, Gibson WS, Round JL, Scholz RL, Chaudhuri AA, Kahn ME, Rao DS, Baltimore D (Oct 2010). "MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development". Immunity. 33 (4): 607–619. doi:10.1016/j.immuni.2010.09.009. PMC   2966521 . PMID   20888269.
• Xia QS, Ishigaki Y, Zhao X, Shimasaki T, Nakajima H, Nakagawa H, Takegami T, Chen ZH, Motoo Y (Jan 2011). "Human SMG-1 is involved in gemcitabine-induced primary microRNA-155/BIC up-regulation in human pancreatic cancer PANC-1 cells". Pancreas. 40 (1): 55–60. doi:10.1097/MPA.0b013e3181e89f74. PMID   20871480. S2CID   39789659.
• Zhou H, Huang X, Cui H, Luo X, Tang Y, Chen S, Wu L, Shen N (Dec 2010). "miR-155 and its star-form partner miR-155* cooperatively regulate type I interferon production by human plasmacytoid dendritic cells". Blood. 116 (26): 5885–5894. doi: 10.1182/blood-2010-04-280156 . PMID   20852130.
• Linnstaedt SD, Gottwein E, Skalsky RL, Luftig MA, Cullen BR (Nov 2010). "Virally induced cellular microRNA miR-155 plays a key role in B-cell immortalization by Epstein-Barr virus". Journal of Virology. 84 (22): 11670–11678. doi:10.1128/JVI.01248-10. PMC   2977875 . PMID   20844043.
• Zheng L, Xu CC, Chen WD, Shen WL, Ruan CC, Zhu LM, Zhu DL, Gao PJ (Oct 2010). "MicroRNA-155 regulates angiotensin II type 1 receptor expression and phenotypic differentiation in vascular adventitial fibroblasts". Biochemical and Biophysical Research Communications. 400 (4): 483–488. doi:10.1016/j.bbrc.2010.08.067. PMID   20735984.
• Tili E, Michaille JJ, Adair B, Alder H, Limagne E, Taccioli C, Ferracin M, Delmas D, Latruffe N, Croce CM (Sep 2010). "Resveratrol decreases the levels of miR-155 by upregulating miR-663, a microRNA targeting JunB and JunD". Carcinogenesis. 31 (9): 1561–1566. doi:10.1093/carcin/bgq143. PMC   4647642 . PMID   20622002.
• Boesch-Saadatmandi C, Loboda A, Wagner AE, Stachurska A, Jozkowicz A, Dulak J, Döring F, Wolffram S, Rimbach G (Mar 2011). "Effect of quercetin and its metabolites isorhamnetin and quercetin-3-glucuronide on inflammatory gene expression: role of miR-155". The Journal of Nutritional Biochemistry. 22 (3): 293–299. doi:10.1016/j.jnutbio.2010.02.008. PMID   20579867.
• Liu J, van Mil A, Vrijsen K, Zhao J, Gao L, Metz CH, Goumans MJ, Doevendans PA, Sluijter JP (Jul 2011). "MicroRNA-155 prevents necrotic cell death in human cardiomyocyte progenitor cells via targeting RIP1". Journal of Cellular and Molecular Medicine. 15 (7): 1474–1482. doi:10.1111/j.1582-4934.2010.01104.x. PMC   3823192 . PMID   20550618.
• Pogribny IP, Starlard-Davenport A, Tryndyak VP, Han T, Ross SA, Rusyn I, Beland FA (Oct 2010). "Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice". Laboratory Investigation. 90 (10): 1437–1446. doi:10.1038/labinvest.2010.113. PMC   4281935 . PMID   20548288.
• Zhang Y, Diao Z, Su L, Sun H, Li R, Cui H, Hu Y (May 2010). "MicroRNA-155 contributes to preeclampsia by down-regulating CYR61". American Journal of Obstetrics and Gynecology. 202 (5): 466.e1–7. doi:10.1016/j.ajog.2010.01.057. PMID   20452491.
• Hu YL, Fong S, Largman C, Shen WF (Sep 2010). "HOXA9 regulates miR-155 in hematopoietic cells". Nucleic Acids Research. 38 (16): 5472–5478. doi:10.1093/nar/gkq337. PMC   2938212 . PMID   20444872.
• McCoy CE, Sheedy FJ, Qualls JE, Doyle SL, Quinn SR, Murray PJ, O'Neill LA (Jul 2010). "IL-10 inhibits miR-155 induction by toll-like receptors". The Journal of Biological Chemistry. 285 (27): 20492–20498. doi: 10.1074/jbc.M110.102111 . PMC   2898307 . PMID   20435894.
• Yin Q, Wang X, Fewell C, Cameron J, Zhu H, Baddoo M, Lin Z, Flemington EK (Jul 2010). "MicroRNA miR-155 inhibits bone morphogenetic protein (BMP) signaling and BMP-mediated Epstein-Barr virus reactivation". Journal of Virology. 84 (13): 6318–6327. doi:10.1128/JVI.00635-10. PMC   2903268 . PMID   20427544.
• Zhu J, Hu XQ, Guo GL, Zhang Y, Wang OC, You J, Huang QD, Zhang XH (Feb 2010). "[Expression and its clinical significance of miR-155 in human primary breast cancer]". Zhonghua Wai Ke Za Zhi [Chinese Journal of Surgery]. 48 (3): 205–208. PMID   20388420.
• Kong W, He L, Coppola M, Guo J, Esposito NN, Coppola D, Cheng JQ (Jun 2010). "MicroRNA-155 regulates cell survival, growth, and chemosensitivity by targeting FOXO3a in breast cancer". The Journal of Biological Chemistry. 285 (23): 17869–17879. doi: 10.1074/jbc.M110.101055 . PMC   2878550 . PMID   20371610.
• Xia QS, Ishigaki Y, Sun L, Chen R, Motoo Y (Jan 2010). "[Effect of anti-cancer drugs on the expression of BIC/miR-155 in human pancreatic cancer PANC-1 cells]". Zhonghua Yi Xue Za Zhi. 90 (2): 123–127. PMID   20356498.
• Jiang S, Zhang HW, Lu MH, He XH, Li Y, Gu H, Liu MF, Wang ED (Apr 2010). "MicroRNA-155 functions as an OncomiR in breast cancer by targeting the suppressor of cytokine signaling 1 gene". Cancer Research. 70 (8): 3119–3127. doi: 10.1158/0008-5472.CAN-09-4250 . PMID   20354188.
• Ryu JK, Hong SM, Karikari CA, Hruban RH, Goggins MG, Maitra A (2010). "Aberrant MicroRNA-155 expression is an early event in the multistep progression of pancreatic adenocarcinoma". Pancreatology. 10 (1): 66–73. doi:10.1159/000231984. PMC   2865485 . PMID   20332664.
• Fabani MM, Abreu-Goodger C, Williams D, Lyons PA, Torres AG, Smith KG, Enright AJ, Gait MJ, Vigorito E (Jul 2010). "Efficient inhibition of miR-155 function in vivo by peptide nucleic acids". Nucleic Acids Research. 38 (13): 4466–4475. doi:10.1093/nar/gkq160. PMC   2910044 . PMID   20223773.
• Tang B, Xiao B, Liu Z, Li N, Zhu ED, Li BS, Xie QH, Zhuang Y, Zou QM, Mao XH (Apr 2010). "Identification of MyD88 as a novel target of miR-155, involved in negative regulation of Helicobacter pylori-induced inflammation". FEBS Letters. 584 (8): 1481–1486. doi:10.1016/j.febslet.2010.02.063. PMID   20219467. S2CID   41984991.
• Fassi Fehri L, Koch M, Belogolova E, Khalil H, Bolz C, Kalali B, Mollenkopf HJ, Beigier-Bompadre M, Karlas A, Schneider T, Churin Y, Gerhard M, Meyer TF (2010). "Helicobacter pylori induces miR-155 in T cells in a cAMP-Foxp3-dependent manner". PLOS ONE. 5 (3): e9500. Bibcode:2010PLoSO...5.9500F. doi: 10.1371/journal.pone.0009500 . PMC   2830477 . PMID   20209161.
• Sidorkiewicz M, Grek M, Jozwiak B, Majda-Stanislawska E, Piekarska A, Bartkowiak J (2010). "Expression of microRNA-155 precursor in peripheral blood mononuclear cells from Hepatitis C patients after antiviral treatment". Acta Virologica. 54 (1): 75–78. doi:10.4149/av_2010_01_75. PMID   20201617.
• Gueta K, Molotski N, Gerchikov N, Mor E, Savion S, Fein A, Toder V, Shomron N, Torchinsky A (2010). "Teratogen-induced alterations in microRNA-34, microRNA-125b and microRNA-155 expression: correlation with embryonic p53 genotype and limb phenotype". BMC Developmental Biology. 10: 20. doi: 10.1186/1471-213X-10-20 . PMC   2841584 . PMID   20170545.
• Rai D, Kim SW, McKeller MR, Dahia PL, Aguiar RC (Feb 2010). "Targeting of SMAD5 links microRNA-155 to the TGF-beta pathway and lymphomagenesis". Proceedings of the National Academy of Sciences of the United States of America. 107 (7): 3111–3116. Bibcode:2010PNAS..107.3111R. doi: 10.1073/pnas.0910667107 . PMC   2840369 . PMID   20133617.
• Cremer TJ, Ravneberg DH, Clay CD, Piper-Hunter MG, Marsh CB, Elton TS, Gunn JS, Amer A, Kanneganti TD, Schlesinger LS, Butchar JP, Tridandapani S (2009). "MiR-155 induction by F. novicida but not the virulent F. tularensis results in SHIP down-regulation and enhanced pro-inflammatory cytokine response". PLOS ONE. 4 (12): e8508. Bibcode:2009PLoSO...4.8508C. doi: 10.1371/journal.pone.0008508 . PMC   2794384 . PMID   20041145.
• Forrest AR, Kanamori-Katayama M, Tomaru Y, Lassmann T, Ninomiya N, Takahashi Y, de Hoon MJ, Kubosaki A, Kaiho A, Suzuki M, Yasuda J, Kawai J, Hayashizaki Y, Hume DA, Suzuki H (Feb 2010). "Induction of microRNAs, mir-155, mir-222, mir-424 and mir-503, promotes monocytic differentiation through combinatorial regulation". Leukemia. 24 (2): 460–466. arXiv: 1007.2689 . doi:10.1038/leu.2009.246. PMID   19956200. S2CID   2333658.
• Pedersen IM, Otero D, Kao E, Miletic AV, Hother C, Ralfkiaer E, Rickert RC, Gronbaek K, David M (Aug 2009). "Onco-miR-155 targets SHIP1 to promote TNFalpha-dependent growth of B cell lymphomas". EMBO Molecular Medicine. 1 (5): 288–295. doi:10.1002/emmm.200900028. PMC   2771872 . PMID   19890474.
• He M, Xu Z, Ding T, Kuang DM, Zheng L (Oct 2009). "MicroRNA-155 regulates inflammatory cytokine production in tumor-associated macrophages via targeting C/EBPbeta". Cellular & Molecular Immunology. 6 (5): 343–352. doi:10.1038/cmi.2009.45. PMC   4003217 . PMID   19887047.
• Tili E, Croce CM, Michaille JJ (2009). "miR-155: on the crosstalk between inflammation and cancer". International Reviews of Immunology. 28 (5): 264–284. doi:10.1080/08830180903093796. PMID   19811312. S2CID   205589961.
• Stahl HF, Fauti T, Ullrich N, Bopp T, Kubach J, Rust W, Labhart P, Alexiadis V, Becker C, Hafner M, Weith A, Lenter MC, Jonuleit H, Schmitt E, Mennerich D (2009). "miR-155 inhibition sensitizes CD4+ Th cells for TREG mediated suppression". PLOS ONE. 4 (9): e7158. Bibcode:2009PLoSO...4.7158S. doi: 10.1371/journal.pone.0007158 . PMC   2743997 . PMID   19777054.
• Bolisetty MT, Dy G, Tam W, Beemon KL (Dec 2009). "Reticuloendotheliosis virus strain T induces miR-155, which targets JARID2 and promotes cell survival". Journal of Virology. 83 (23): 12009–12017. doi:10.1128/JVI.01182-09. PMC   2786729 . PMID   19759154.
• Wang B, Majumder S, Nuovo G, Kutay H, Volinia S, Patel T, Schmittgen TD, Croce C, Ghoshal K, Jacob ST (Oct 2009). "Role of microRNA-155 at early stages of hepatocarcinogenesis induced by choline-deficient and amino acid-defined diet in C57BL/6 mice". Hepatology. 50 (4): 1152–1161. doi:10.1002/hep.23100. PMC   2757532 . PMID   19711427.
• Pottier N, Maurin T, Chevalier B, Puisségur MP, Lebrigand K, Robbe-Sermesant K, Bertero T, Lino Cardenas CL, Courcot E, Rios G, Fourre S, Lo-Guidice JM, Marcet B, Cardinaud B, Barbry P, Mari B (2009). "Identification of keratinocyte growth factor as a target of microRNA-155 in lung fibroblasts: implication in epithelial-mesenchymal interactions". PLOS ONE. 4 (8): e6718. Bibcode:2009PLoSO...4.6718P. doi: 10.1371/journal.pone.0006718 . PMC   2726943 . PMID   19701459.
• Xiao B, Liu Z, Li BS, Tang B, Li W, Guo G, Shi Y, Wang F, Wu Y, Tong WD, Guo H, Mao XH, Zou QM (Sep 2009). "Induction of microRNA-155 during Helicobacter pylori infection and its negative regulatory role in the inflammatory response". The Journal of Infectious Diseases. 200 (6): 916–925. doi:10.1086/605443. PMID   19650740. S2CID   8719437.
• Worm J, Stenvang J, Petri A, Frederiksen KS, Obad S, Elmén J, Hedtjärn M, Straarup EM, Hansen JB, Kauppinen S (Sep 2009). "Silencing of microRNA-155 in mice during acute inflammatory response leads to derepression of c/ebp Beta and down-regulation of G-CSF". Nucleic Acids Research. 37 (17): 5784–5792. doi:10.1093/nar/gkp577. PMC   2761263 . PMID   19596814.
• Costinean S, Sandhu SK, Pedersen IM, Tili E, Trotta R, Perrotti D, Ciarlariello D, Neviani P, Harb J, Kauffman LR, Shidham A, Croce CM (Aug 2009). "Src homology 2 domain-containing inositol-5-phosphatase and CCAAT enhancer-binding protein beta are targeted by miR-155 in B cells of Emicro-MiR-155 transgenic mice". Blood. 114 (7): 1374–1382. doi:10.1182/blood-2009-05-220814. PMC   2727407 . PMID   19520806.
• Ruggiero T, Trabucchi M, De Santa F, Zupo S, Harfe BD, McManus MT, Rosenfeld MG, Briata P, Gherzi R (Sep 2009). "LPS induces KH-type splicing regulatory protein-dependent processing of microRNA-155 precursors in macrophages". FASEB Journal. 23 (9): 2898–2908. doi:10.1096/fj.09-131342. PMID   19423639. S2CID   588328.
• Martinez-Nunez RT, Louafi F, Friedmann PS, Sanchez-Elsner T (Jun 2009). "MicroRNA-155 modulates the pathogen binding ability of dendritic cells (DCs) by down-regulation of DC-specific intercellular adhesion molecule-3 grabbing non-integrin (DC-SIGN)". The Journal of Biological Chemistry. 284 (24): 16334–16342. doi: 10.1074/jbc.M109.011601 . PMC   2713543 . PMID   19386588.
• O'Connell RM, Chaudhuri AA, Rao DS, Baltimore D (Apr 2009). "Inositol phosphatase SHIP1 is a primary target of miR-155". Proceedings of the National Academy of Sciences of the United States of America. 106 (17): 7113–7118. Bibcode:2009PNAS..106.7113O. doi: 10.1073/pnas.0902636106 . PMC   2678424 . PMID   19359473.
• Kohlhaas S, Garden OA, Scudamore C, Turner M, Okkenhaug K, Vigorito E (Mar 2009). "Cutting edge: the Foxp3 target miR-155 contributes to the development of regulatory T cells". Journal of Immunology. 182 (5): 2578–2582. doi: 10.4049/jimmunol.0803162 . PMID   19234151.
• Ceppi M, Pereira PM, Dunand-Sauthier I, Barras E, Reith W, Santos MA, Pierre P (Feb 2009). "MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells". Proceedings of the National Academy of Sciences of the United States of America. 106 (8): 2735–2740. Bibcode:2009PNAS..106.2735C. doi: 10.1073/pnas.0811073106 . PMC   2650335 . PMID   19193853.
• Habbe N, Koorstra JB, Mendell JT, Offerhaus GJ, Ryu JK, Feldmann G, Mullendore ME, Goggins MG, Hong SM, Maitra A (Feb 2009). "MicroRNA miR-155 is a biomarker of early pancreatic neoplasia". Cancer Biology & Therapy. 8 (4): 340–346. doi:10.4161/cbt.8.4.7338. PMC   2692997 . PMID   19106647.
• Jung I, Aguiar RC (Jan 2009). "MicroRNA-155 expression and outcome in diffuse large B-cell lymphoma". British Journal of Haematology. 144 (1): 138–140. doi:10.1111/j.1365-2141.2008.07424.x. PMC   4654117 . PMID   19016736.
• Romania P, Lulli V, Pelosi E, Biffoni M, Peschle C, Marziali G (Nov 2008). "MicroRNA 155 modulates megakaryopoiesis at progenitor and precursor level by targeting Ets-1 and Meis1 transcription factors". British Journal of Haematology. 143 (4): 570–580. doi: 10.1111/j.1365-2141.2008.07382.x . PMID   18950466. S2CID   9025761.
• Zhao Y, Yao Y, Xu H, Lambeth L, Smith LP, Kgosana L, Wang X, Nair V (Jan 2009). "A functional MicroRNA-155 ortholog encoded by the oncogenic Marek's disease virus". Journal of Virology. 83 (1): 489–492. doi:10.1128/JVI.01166-08. PMC   2612317 . PMID   18945769.
• Gatto G, Rossi A, Rossi D, Kroening S, Bonatti S, Mallardo M (Nov 2008). "Epstein-Barr virus latent membrane protein 1 trans-activates miR-155 transcription through the NF-kappaB pathway". Nucleic Acids Research. 36 (20): 6608–6619. doi:10.1093/nar/gkn666. PMC   2582607 . PMID   18940871.
• Rahadiani N, Takakuwa T, Tresnasari K, Morii E, Aozasa K (Dec 2008). "Latent membrane protein-1 of Epstein-Barr virus induces the expression of B-cell integration cluster, a precursor form of microRNA-155, in B lymphoma cell lines". Biochemical and Biophysical Research Communications. 377 (2): 579–583. doi:10.1016/j.bbrc.2008.10.007. PMID   18926796.
• Kong W, Yang H, He L, Zhao JJ, Coppola D, Dalton WS, Cheng JQ (Nov 2008). "MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA". Molecular and Cellular Biology. 28 (22): 6773–6784. doi:10.1128/MCB.00941-08. PMC   2573297 . PMID   18794355.
• Lu F, Weidmer A, Liu CG, Volinia S, Croce CM, Lieberman PM (Nov 2008). "Epstein-Barr virus-induced miR-155 attenuates NF-kappaB signaling and stabilizes latent virus persistence". Journal of Virology. 82 (21): 10436–10443. doi:10.1128/JVI.00752-08. PMC   2573162 . PMID   18753206.
• Dorsett Y, McBride KM, Jankovic M, Gazumyan A, Thai TH, Robbiani DF, Di Virgilio M, Reina San-Martin B, Heidkamp G, Schwickert TA, Eisenreich T, Rajewsky K, Nussenzweig MC (May 2008). "MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation". Immunity. 28 (5): 630–638. doi:10.1016/j.immuni.2008.04.002. PMC   2713656 . PMID   18455451.
• Teng G, Hakimpour P, Landgraf P, Rice A, Tuschl T, Casellas R, Papavasiliou FN (May 2008). "MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase". Immunity. 28 (5): 621–629. doi:10.1016/j.immuni.2008.03.015. PMC   2430982 . PMID   18450484.
• Yin Q, McBride J, Fewell C, Lacey M, Wang X, Lin Z, Cameron J, Flemington EK (Jun 2008). "MicroRNA-155 is an Epstein-Barr virus-induced gene that modulates Epstein-Barr virus-regulated gene expression pathways". Journal of Virology. 82 (11): 5295–5306. doi:10.1128/JVI.02380-07. PMC   2395216 . PMID   18367535.
• Zhang T, Nie K, Tam W (Sep 2008). "BIC is processed efficiently to microRNA-155 in Burkitt lymphoma cells". Leukemia. 22 (9): 1795–1797. doi:10.1038/leu.2008.62. PMID   18354490. S2CID   8783237.
• Wang M, Tan LP, Dijkstra MK, van Lom K, Robertus JL, Harms G, Blokzijl T, Kooistra K, van T'veer MB, Rosati S, Visser L, Jongen-Lavrencic M, Kluin PM, van den Berg A (May 2008). "miRNA analysis in B-cell chronic lymphocytic leukaemia: proliferation centres characterized by low miR-150 and high BIC/miR-155 expression". The Journal of Pathology. 215 (1): 13–20. doi:10.1002/path.2333. PMID   18348159. S2CID   29470560.
• O'Connell RM, Rao DS, Chaudhuri AA, Boldin MP, Taganov KD, Nicoll J, Paquette RL, Baltimore D (Mar 2008). "Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder". The Journal of Experimental Medicine. 205 (3): 585–594. doi:10.1084/jem.20072108. PMC   2275382 . PMID   18299402.
• Rai D, Karanti S, Jung I, Dahia PL, Aguiar RC (Feb 2008). "Coordinated expression of microRNA-155 and predicted target genes in diffuse large B-cell lymphoma". Cancer Genetics and Cytogenetics. 181 (1): 8–15. doi:10.1016/j.cancergencyto.2007.10.008. PMC   2276854 . PMID   18262046.
• Gottwein E, Mukherjee N, Sachse C, Frenzel C, Majoros WH, Chi JT, Braich R, Manoharan M, Soutschek J, Ohler U, Cullen BR (Dec 2007). "A viral microRNA functions as an orthologue of cellular miR-155". Nature. 450 (7172): 1096–1099. Bibcode:2007Natur.450.1096G. doi:10.1038/nature05992. PMC   2614920 . PMID   18075594.
• Vigorito E, Perks KL, Abreu-Goodger C, Bunting S, Xiang Z, Kohlhaas S, Das PP, Miska EA, Rodriguez A, Bradley A, Smith KG, Rada C, Enright AJ, Toellner KM, Maclennan IC, Turner M (Dec 2007). "microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells". Immunity. 27 (6): 847–859. doi:10.1016/j.immuni.2007.10.009. PMC   4135426 . PMID   18055230.
• Yin Q, Wang X, McBride J, Fewell C, Flemington E (Feb 2008). "B-cell receptor activation induces BIC/miR-155 expression through a conserved AP-1 element". The Journal of Biological Chemistry. 283 (5): 2654–2662. doi: 10.1074/jbc.M708218200 . PMC   2810639 . PMID   18048365.
• Tili E, Michaille JJ, Cimino A, Costinean S, Dumitru CD, Adair B, Fabbri M, Alder H, Liu CG, Calin GA, Croce CM (Oct 2007). "Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock". Journal of Immunology. 179 (8): 5082–5089. doi: 10.4049/jimmunol.179.8.5082 . PMID   17911593.
• Gironella M, Seux M, Xie MJ, Cano C, Tomasini R, Gommeaux J, Garcia S, Nowak J, Yeung ML, Jeang KT, Chaix A, Fazli L, Motoo Y, Wang Q, Rocchi P, Russo A, Gleave M, Dagorn JC, Iovanna JL, Carrier A, Pébusque MJ, Dusetti NJ (Oct 2007). "Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development". Proceedings of the National Academy of Sciences of the United States of America. 104 (41): 16170–16175. Bibcode:2007PNAS..10416170G. doi: 10.1073/pnas.0703942104 . PMC   2042180 . PMID   17911264.
• Skalsky RL, Samols MA, Plaisance KB, Boss IW, Riva A, Lopez MC, Baker HV, Renne R (Dec 2007). "Kaposi's sarcoma-associated herpesvirus encodes an ortholog of miR-155". Journal of Virology. 81 (23): 12836–12845. doi:10.1128/JVI.01804-07. PMC   2169101 . PMID   17881434.
• Sethupathy P, Borel C, Gagnebin M, Grant GR, Deutsch S, Elton TS, Hatzigeorgiou AG, Antonarakis SE (Aug 2007). "Human microRNA-155 on chromosome 21 differentially interacts with its polymorphic target in the AGTR1 3′ untranslated region: a mechanism for functional single-nucleotide polymorphisms related to phenotypes". American Journal of Human Genetics. 81 (2): 405–413. doi:10.1086/519979. PMC   1950808 . PMID   17668390.
• Martin MM, Buckenberger JA, Jiang J, Malana GE, Nuovo GJ, Chotani M, Feldman DS, Schmittgen TD, Elton TS (Aug 2007). "The human angiotensin II type 1 receptor +1166 A/C polymorphism attenuates microRNA-155 binding". The Journal of Biological Chemistry. 282 (33): 24262–24269. doi: 10.1074/jbc.M701050200 . PMC   2413065 . PMID   17588946.
• Rodriguez A, Vigorito E, Clare S, Warren MV, Couttet P, Soond DR, van Dongen S, Grocock RJ, Das PP, Miska EA, Vetrie D, Okkenhaug K, Enright AJ, Dougan G, Turner M, Bradley A (Apr 2007). "Requirement of bic/microRNA-155 for normal immune function". Science. 316 (5824): 608–611. Bibcode:2007Sci...316..608R. doi:10.1126/science.1139253. PMC   2610435 . PMID   17463290.
• Thai TH, Calado DP, Casola S, Ansel KM, Xiao C, Xue Y, Murphy A, Frendewey D, Valenzuela D, Kutok JL, Schmidt-Supprian M, Rajewsky N, Yancopoulos G, Rao A, Rajewsky K (Apr 2007). "Regulation of the germinal center response by microRNA-155". Science. 316 (5824): 604–608. Bibcode:2007Sci...316..604T. doi:10.1126/science.1141229. PMID   17463289. S2CID   8174458.
• O'Connell RM, Taganov KD, Boldin MP, Cheng G, Baltimore D (Jan 2007). "MicroRNA-155 is induced during the macrophage inflammatory response". Proceedings of the National Academy of Sciences of the United States of America. 104 (5): 1604–1609. Bibcode:2007PNAS..104.1604O. doi: 10.1073/pnas.0610731104 . PMC   1780072 . PMID   17242365.
• Martin MM, Lee EJ, Buckenberger JA, Schmittgen TD, Elton TS (Jul 2006). "MicroRNA-155 regulates human angiotensin II type 1 receptor expression in fibroblasts". The Journal of Biological Chemistry. 281 (27): 18277–18284. doi: 10.1074/jbc.M601496200 . PMC   3567671 . PMID   16675453.
• Chung KH, Hart CC, Al-Bassam S, Avery A, Taylor J, Patel PD, Vojtek AB, Turner DL (2006). "Polycistronic RNA polymerase II expression vectors for RNA interference based on BIC/miR-155". Nucleic Acids Research. 34 (7): e53. doi:10.1093/nar/gkl143. PMC   1435982 . PMID   16614444.
• Tam W, Dahlberg JE (Feb 2006). "miR-155/BIC as an oncogenic microRNA". Genes, Chromosomes & Cancer. 45 (2): 211–212. doi:10.1002/gcc.20282. PMID   16252262. S2CID   8513721.
• Kluiver J, Haralambieva E, de Jong D, Blokzijl T, Jacobs S, Kroesen BJ, Poppema S, van den Berg A (Feb 2006). "Lack of BIC and microRNA miR-155 expression in primary cases of Burkitt lymphoma". Genes, Chromosomes & Cancer. 45 (2): 147–153. doi:10.1002/gcc.20273. PMID   16235244. S2CID   16897980.
• Jiang J, Lee EJ, Schmittgen TD (Jan 2006). "Increased expression of microRNA-155 in Epstein-Barr virus transformed lymphoblastoid cell lines". Genes, Chromosomes & Cancer. 45 (1): 103–106. doi:10.1002/gcc.20264. PMID   16175574. S2CID   19138209.
• Kluiver J, Poppema S, de Jong D, Blokzijl T, Harms G, Jacobs S, Kroesen BJ, van den Berg A (Oct 2005). "BIC and miR-155 are highly expressed in Hodgkin, primary mediastinal and diffuse large B cell lymphomas". The Journal of Pathology. 207 (2): 243–249. doi:10.1002/path.1825. PMID   16041695. S2CID   14329069.
• Eis PS, Tam W, Sun L, Chadburn A, Li Z, Gomez MF, Lund E, Dahlberg JE (Mar 2005). "Accumulation of miR-155 and BIC RNA in human B cell lymphomas". Proceedings of the National Academy of Sciences of the United States of America. 102 (10): 3627–3632. Bibcode:2005PNAS..102.3627E. doi: 10.1073/pnas.0500613102 . PMC   552785 . PMID   15738415.
• Metzler M, Wilda M, Busch K, Viehmann S, Borkhardt A (Feb 2004). "High expression of precursor microRNA-155/BIC RNA in children with Burkitt lymphoma". Genes, Chromosomes & Cancer. 39 (2): 167–169. doi:10.1002/gcc.10316. PMID   14695998. S2CID   10009892.
• Xu Y, Wu J, Yuan X, Liu W, Pan J, Xu B (2021). "MicroRNA-155 contributes to host immunity against Toxoplasma gondii". Parasite. 28: 83. doi:10.1051/parasite/2021082. PMC   8672677 . PMID   34907898.

External links

• miRBase
• miRBase entries for all known mir-155
• Page for mir-155 microRNA precursor family at Rfam