Mir-202 microRNA precursor family

mir-202
Identifiers
Symbol	mir-202
Rfam	RF00705
miRBase family	6
Other data
RNA type	microRNA
Domain	Eukaryota;
PDB structures	PDBe

In molecular biology mir-202 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. The pre-miR-202 in the mouse genome is located fully within an exon, whereas in human it lies across a splice junction. This implies that human miR-202 is exposed to a negative regulation by splicing, whereas murine miR-202 is not. ^[1]

See also

• MicroRNA

References

1. Melamed Z, Levy A, Ashwal-Fluss R, Lev-Maor G, Mekahel K, Atias N, Gilad S, Sharan R, Levy C, Kadener S, Ast G (June 2013). "Alternative splicing regulates biogenesis of miRNAs located across exon-intron junctions". Molecular Cell. 50 (6): 869–81. doi: 10.1016/j.molcel.2013.05.007 . PMID   23747012.

Further reading

• Schrauder MG, Strick R, Schulz-Wendtland R, Strissel PL, Kahmann L, Loehberg CR, Lux MP, Jud SM, Hartmann A, Hein A, Bayer CM, Bani MR, Richter S, Adamietz BR, Wenkel E, Rauh C, Beckmann MW, Fasching PA (2012). Hoheisel JD (ed.). "Circulating micro-RNAs as potential blood-based markers for early stage breast cancer detection". PLOS ONE. 7 (1) e29770. Bibcode:2012PLoSO...729770S. doi: 10.1371/journal.pone.0029770 . PMC   3252341 . PMID   22242178.
• Buechner J, Tømte E, Haug BH, Henriksen JR, Løkke C, Flægstad T, Einvik C (July 2011). "Tumour-suppressor microRNAs let-7 and mir-101 target the proto-oncogene MYCN and inhibit cell proliferation in MYCN-amplified neuroblastoma". British Journal of Cancer. 105 (2): 296–303. doi:10.1038/bjc.2011.220. PMC   3142803 . PMID   21654684.
• Nymark P, Guled M, Borze I, Faisal A, Lahti L, Salmenkivi K, Kettunen E, Anttila S, Knuutila S (August 2011). "Integrative analysis of microRNA, mRNA and aCGH data reveals asbestos- and histology-related changes in lung cancer". Genes, Chromosomes & Cancer. 50 (8): 585–97. doi:10.1002/gcc.20880. PMID   21563230. S2CID   39556202.
• Hawkins SM, Creighton CJ, Han DY, Zariff A, Anderson ML, Gunaratne PH, Matzuk MM (May 2011). "Functional microRNA involved in endometriosis". Molecular Endocrinology. 25 (5): 821–32. doi:10.1210/me.2010-0371. PMC   3082329 . PMID   21436257.
• Muráni E, Ponsuksili S, D'Eath RB, Turner SP, Evans G, Thölking L, Kurt E, Klont R, Foury A, Mormède P, Wimmers K (June 2011). "Differential mRNA expression of genes in the porcine adrenal gland associated with psychosocial stress". Journal of Molecular Endocrinology. 46 (3): 165–74. doi: 10.1530/JME-10-0147 . PMID   21266515.
• Pizzimenti S, Ferracin M, Sabbioni S, Toaldo C, Pettazzoni P, Dianzani MU, Negrini M, Barrera G (January 2009). "MicroRNA expression changes during human leukemic HL-60 cell differentiation induced by 4-hydroxynonenal, a product of lipid peroxidation". Free Radical Biology & Medicine. 46 (2): 282–8. doi:10.1016/j.freeradbiomed.2008.10.035. PMID   19022373.

External links

• Page for mir-202 microRNA precursor family at Rfam