Mucor circinelloides

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Mucor circinelloides
Mucor circinelloides1.jpg
Scientific classification OOjs UI icon edit-ltr.svg
Domain: Eukaryota
Kingdom: Fungi
Division: Mucoromycota
Class: Mucoromycetes
Order: Mucorales
Family: Mucoraceae
Genus: Mucor
Species:
M. circinelloides
Binomial name
Mucor circinelloides
Tieghem (1875)
Synonyms
  • Calyptromyces circinelloides Tiegh. (1910)
  • Circinomucor circinelloides Tiegh. (1982)
  • Mucor javanicus Wehmer, et al. (1900)
  • Mucor dubius Wehmer, et al. (1901)
  • Mucor prainii Chodat & Nechitsche (1904)
  • Mucor mandshuricus(1904)

Mucor circinelloides is a dimorphic fungus [1] belonging to the Order Mucorales (Phylum Mucoromycota). It has a worldwide distribution, found mostly in soil, dung and root vegetables. This species is described as not known to be able to produce mycotoxins, [2] however it has been frequently reported to infect animals such as cattle and swine, as well as fowl, platypus and occasionally humans. [3] [4] Ketoacidotic patients are particularly at risk for infection by M. circinelloides. [3]

Contents

History and taxonomy

Mucor circinelloides is one of the common species in the genus Mucor. [5] Mucor circinelloides is a variable species that include several variants such as; M. circinelloides f. circinelloides; M. circinelloides f. lusitanicus; M. circinelloides f. griseocyanus and M. circinelloides f. janssenii. [6]

Growth and morphology

Mucor circinelloides reproduce both asexually and sexually [7] . The asexual sporangiophores are found as two types: elongate and sympodially branched. [6] The elongate sporangiophores have larger sporangia, which are white at first and progressively turn greenish brown in colour. [6] They assume a globose shape and are 40–80 μm in size; characterized as "bobbing heads". [6] Sporangiophores are mostly sympodially branched [5] with small sporangia (25 μm); [6] branches are and sometimes circinate. [8] The diameter of the sporangia range from 20 to 80 μm. [8] Sporangia have slightly encrusted walls. [5] In larger sporangia, the membranes are deliquescent, whereas they are persistent in the smaller ones and rupture at maturity. [8] [5] Smaller sporangia also have smooth persistent walls. [6] Sporangiophores are ellipsoid (6–7 μm in diameter) or subglobose (4–6 μm in diameter). [8] Numerous chlamydospores are also produced. [5]

Colonies are fast growing and go up to 2 cm in height. [6] On Czapek Yeast Autolysate (CYA) plates, the colony growth is low and sparse, most often spreading across the entire Petri dish. [2] These colonies of 60 mm diameter or more appear to be pale grey or yellow in colour, with the reverse being uncoloured. [2] Colonies also fill up the entire Petri dish of malt extract agar, producing colony colours similar to those observed on CYA. [2] Mucor circinelloides can assume a yeast-like growth form. [6] It has been isolated in this yeast form from human urine and normal stool specimen. [6] It has also been recovered as a yeast from frogs. [6]

Physiology

Mucor circinelloides has good growth and sporulation between 5–10 °C [4] [5] and very poor growth at 37 °C which is also the maximum growth temperature. [5] [3] The minimal water activity(aw) for growth is 0.9. [4] M. circinelloides assimilates ethanol and nitrate. [3] The length and number of tall sporangiophores decrease with lower temperatures. [4] Spores are broadly ellipsoid (4.4-6.8 x 3.7-4.7 μm [5] Growth, sporulation, and presence of tall and short sporangiophores can be influenced by temperature; however sporangiophore shape, size and uniformity are not influenced by temperatures. [4]

Habitat and ecology

At least 20 species belonging to the genus Mucor are found to be extracted from food. [4] M. circinelloides is one of the five most significant fungus out of these 20 along with M. hiemalis, M. piriformis, M. plumbeus and M. racemosus. [4] It has been reported to spoil cheese and yams as well as diseases of mango. [2] This fungus has also been isolated from various foods such as meat, hazelnuts, walnuts, maize, mung beans, soybeans and barley. [2]

Fungi in the order Mucorales class have not been investigated in detail for their ability to produce mycotoxins; [9] Cytotoxicity and mycotoxin-production was analysed and tested for using the cytotoxicity test (MTT assay) and LC/MS/MS-based multimycotoxin method respectively for three fungal species, including M. circinelloides. [9] Mucor circinelloides was found to be able to produce 3-nitropropionic acid as well as have low cytotoxicity. [9] Conventionally, M. circinelloides is considered not to produce mycotoxins. [2]

Pathogenicity

Mucor circinelloides is considered an emerging pathogen, although it has only been associated rarely with very human disease and have been limited to cutaneous infection. [10] This species is occasionally isolated from humans, birds, cattle, and swine. [6]

Antioxidant potential

Mucor circinelloides is potentially a rich source of antioxidants and other secondary metabolites which could be used in the development of nutraceuticals and natural antioxidants. [11]

References

  1. ↑ Lubbenhusen, T.L; Nielsen, J.; McIntyre, M. (2003). "Characterization of the Mucor circinelloides life cycle by on-line image analysis". J Appl Microbiol. 95 (5): 1152–60. doi:10.1046/j.1365-2672.2003.02098.x. PMID   14633045.
  2. 1 2 3 4 5 6 7 Pitt, J.I.; Hocking, A.D. (1999). Fungi and food spoilage (2nd ed.). Gaithersburg, Md.: Aspen Publications. ISBN   0-8342-1306-0.
  3. 1 2 3 4 de Hoog, G.S; Guarro, J.; Gene, J.; Figueras, M.J (2000). Atlas of clinical fungi (2nd ed.). Utrecht: Centraalbureau voor Schimmelcultures [u.a.] ISBN   90-70351-43-9.
  4. 1 2 3 4 5 6 7 Samson, R.A; Hoekstra, E.S; Frisvad, J.C; Filtenbog, Ole (2000). Introduction to food- and airborne fungi (6th rev. ed.). Utrecht: Centraalbureau voor Schimmelcultures. ISBN   90-70351-42-0.
  5. 1 2 3 4 5 6 7 8 Watanabe, Tsuneo (2009). Pictorial atlas of soil and seed fungi : morphologies of cultured fungi and key to species (3rd ed.). Boca Raton, Fla.: CRC. ISBN   978-1-4398-0419-3.
  6. 1 2 3 4 5 6 7 8 9 10 11 Rippon, John Willard (1988). Medical mycology : the pathogenic fungi and the pathogenic actinomycetes (3rd ed.). Philadelphia: W.B. Saunders Co. ISBN   0-7216-2444-8.
  7. ↑ Schipper (1978). "The genus Mucor contains about 50 recognised taxa, many of which have widespread occurrence and are of considerable economic importance".
  8. 1 2 3 4 Howard, D.H (2003). Pathogenic Fungi in Humans and Animals (3rd ed.). United States of America: Marcel Dekker, Inc. ISBN   9780824706838.
  9. 1 2 3 Hollmann, M.; Razzazi-Fazeli, E.; Grajewski, J.; Twaruzek, M/; Sulyok, M.; Bohm, J. (2008). "Detection of 3-nitropropionic acid and cytoxicity in Mucor circinelloides". Mycotoxin Research. 24 (3): 140–150. doi:10.1007/BF03032341. PMID   23604749.
  10. ↑ Murray, [American Society for Microbiology]. Ed. in chief Patrick R. (1999). Manual of clinical microbiology (7th ed.). Washington, DC: ASM Press. ISBN   1-55581-126-4.
  11. ↑ Hameed, Ahsan; Hussain, Syed Ammar; Yang, Junhuan; Ijaz, Muhammad Umair; Liu, Qing; Suleria, Hafiz Ansar Rasul; Song, Yuanda (2017-10-07). "Antioxidants Potential of the Filamentous Fungi (Mucor circinelloides)". Nutrients. 9 (10): 1101. doi: 10.3390/nu9101101 . PMC   5691717 . PMID   28991177.
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