Neuromedin S

Last updated
Neuromedin S
Identifiers
SymbolNMS
NCBI gene 129521
HGNC 32203
Other data
Locus Chr. 2 q11.2

Neuromedin S is a 36-amino acid neuropeptide found in the brain of humans and other mammals. It is produced in the suprachiasmatic nucleus of the hypothalamus and is related to neuromedin U. It is thought to be involved in regulation of circadian rhythm and also has appetite suppressant effects, [1] [2] [3] [4] [5] as well as regulating the release of several other peptide hormones including vasopressin, [6] luteinizing hormone, [7] and oxytocin. [8]

See also

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References

  1. Mori K, Miyazato M, Ida T, Murakami N, Serino R, Ueta Y, Kojima M, Kangawa K (January 2005). "Identification of neuromedin S and its possible role in the mammalian circadian oscillator system". The EMBO Journal. 24 (2): 325–35. doi:10.1038/sj.emboj.7600526. PMC   545815 . PMID   15635449.
  2. Mori K, Miyazato M, Kangawa K (2008). "Neuromedin S: discovery and functions". Results and Problems in Cell Differentiation. 46: 201–12. doi:10.1007/400_2007_054. ISBN   978-3-540-78350-3. PMID   18214396.
  3. Novak CM (July 2009). "Neuromedin S and U". Endocrinology. 150 (7): 2985–7. doi:10.1210/en.2009-0448. PMC   2703548 . PMID   19549882.
  4. Peier A, Kosinski J, Cox-York K, Qian Y, Desai K, Feng Y, Trivedi P, Hastings N, Marsh DJ (July 2009). "The antiobesity effects of centrally administered neuromedin U and neuromedin S are mediated predominantly by the neuromedin U receptor 2 (NMUR2)". Endocrinology. 150 (7): 3101–9. doi:10.1210/en.2008-1772. PMC   2703546 . PMID   19324999.
  5. Mitchell J, Maguire J, Davenport A (June 2009). "Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin S". British Journal of Pharmacology . 158 (1): 87–103. doi:10.1111/j.1476-5381.2009.00252.x. PMC   2795236 . PMID   19519756.
  6. Sakamoto T, Mori K, Nakahara K, Miyazato M, Kangawa K, Sameshima H, Murakami N (September 2007). "Neuromedin S exerts an antidiuretic action in rats". Biochemical and Biophysical Research Communications. 361 (2): 457–61. doi:10.1016/j.bbrc.2007.07.036. PMID   17645872.
  7. Vigo E, Roa J, López M, Castellano JM, Fernandez-Fernandez R, Navarro VM, Pineda R, Aguilar E, Diéguez C, Pinilla L, Tena-Sempere M (February 2007). "Neuromedin s as novel putative regulator of luteinizing hormone secretion". Endocrinology. 148 (2): 813–23. doi: 10.1210/en.2006-0636 . PMID   17110433.
  8. Sakamoto T, Mori K, Miyazato M, Kangawa K, Sameshima H, Nakahara K, Murakami N (October 2008). "Involvement of neuromedin S in the oxytocin release response to suckling stimulus". Biochemical and Biophysical Research Communications. 375 (1): 49–53. doi:10.1016/j.bbrc.2008.07.124. PMID   18675786.