PARG

For the Armenian singer, see Parg (musician).

PARG
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4B1J, 5A7R, 4A0D, 4B1I, 4B1H, 4B1G
Identifiers
Aliases	PARG , PARG99, poly(ADP-ribose) glycohydrolase
External IDs	OMIM: 603501; MGI: 1347094; HomoloGene: 50532; GeneCards: PARG; OMA:PARG - orthologs
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q11.23 Start 49,818,279 bp [1] End 49,970,203 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14|14 B Start 31,923,906 bp [2] End 32,019,507 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon germinal epithelium testicle kidney tubule ventricular zone epithelium of nasopharynx ganglionic eminence corpus callosum gingival epithelium Skeletal muscle tissue of biceps brachii Top expressed in Gonadal ridge primitive streak stria vascularis pineal gland epiblast ureter morula tail of embryo morula abdominal wall More reference expression data BioGPS n/a
Gene ontology Molecular function hydrolase activity poly(ADP-ribose) glycohydrolase activity protein binding Cellular component mitochondrial matrix intracellular membrane-bounded organelle mitochondrion nucleus nucleoplasm cytoplasm cytosol Biological process ATP generation from poly-ADP-D-ribose carbohydrate metabolic process regulation of DNA repair nucleotide-sugar metabolic process cellular response to DNA damage stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8505 26430 Ensembl ENSG00000227345 ENSMUSG00000021911 UniProt Q86W56 O88622 RefSeq (mRNA) NM_001303486 NM_001303487 NM_001303489 NM_003631 NM_001324381 NM_011960 NM_001359915 NM_001374221 RefSeq (protein) NP_001290415 NP_001290416 NP_001290418 NP_001311310 NP_003622 NP_036090 NP_001346844 NP_001361150 Location (UCSC) Chr 10: 49.82 – 49.97 Mb Chr 14: 31.92 – 32.02 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Poly (ADP-ribose) glycohydrolase is an enzyme that in humans is encoded by the PARG gene. ^{[5] [6] [7]}

Poly (ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly (ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000227345 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021911 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Poly (ADP-ribose) glycohydrolase" . Retrieved 2011-11-08.
6. Lin W, Amé JC, Aboul-Ela N, Jacobson EL, Jacobson MK (May 1997). "Isolation and characterization of the cDNA encoding bovine poly(ADP-ribose) glycohydrolase". J. Biol. Chem. 272 (18): 11895–901. doi: 10.1074/jbc.272.18.11895 . PMID   9115250.
7. Amé JC, Apiou F, Jacobson EL, Jacobson MK (1999). "Assignment of the poly(ADP-ribose) glycohydrolase gene (PARG) to human chromosome 10q11.23 and mouse chromosome 14B by in situ hybridization". Cytogenet. Cell Genet. 85 (3–4): 269–70. doi:10.1159/000015310. PMID   10449915. S2CID   42156664.

Further reading

• Affar, E. B.; Germain, M.; Winstall, E.; Vodenicharov, M.; Shah, R. G.; Salvesen, G. S.; Poirier, G. G. (2000). "Caspase-3-mediated Processing of Poly(ADP-ribose) Glycohydrolase during Apoptosis". Journal of Biological Chemistry. 276 (4): 2935–2942. doi: 10.1074/jbc.M007269200 . PMID   11053413.
• Ohashi, S.; Kanai, M.; Hanai, S.; Uchiumi, F.; Maruta, H.; Tanuma, S.; Miwa, M. (2003). "Subcellular localization of poly(ADP-ribose) glycohydrolase in mammalian cells". Biochemical and Biophysical Research Communications. 307 (4): 915–921. Bibcode:2003BBRC..307..915O. doi:10.1016/S0006-291X(03)01272-5. PMID   12878198.
• Meyer, R. G.; Meyer-Ficca, M. L.; Jacobson, E. L.; Jacobson, M. K. (2003). "Human poly(ADP-ribose) glycohydrolase (PARG) gene and the common promoter sequence it shares with inner mitochondrial membrane translocase 23 (TIM23)". Gene. 314: 181–190. doi:10.1016/S0378-1119(03)00738-8. PMID   14527731.
• Golovanov, A. P.; Barillà, D.; Golovanova, M.; Hayes, F.; Lian, L. Y. (2003). "ParG, a protein required for active partition of bacterial plasmids, has a dimeric ribbon-helix-helix structure". Molecular Microbiology. 50 (4): 1141–1153. doi:10.1046/j.1365-2958.2003.03750.x. PMID   14622405. S2CID   45704180.
• Keil, C.; Petermann, E.; Oei, S. L. (2004). "Tannins elevate the level of poly(ADP–ribose) in HeLa cell extracts". Archives of Biochemistry and Biophysics. 425 (1): 115–121. doi:10.1016/j.abb.2004.02.024. PMID   15081900.
• Meyer-Ficca, M. L.; Meyer, R. G.; Coyle, D. L.; Jacobson, E. L.; Jacobson, M. K. (2004). "Human poly(ADP-ribose) glycohydrolase is expressed in alternative splice variants yielding isoforms that localize to different cell compartments". Experimental Cell Research. 297 (2): 521–532. doi: 10.1016/j.yexcr.2004.03.050 . PMID   15212953.
• Putt, K. S.; Hergenrother, P. J. (2004). "A nonradiometric, high-throughput assay for poly(ADP-ribose) glycohydrolase (PARG): Application to inhibitor identification and evaluation". Analytical Biochemistry. 333 (2): 256–264. doi:10.1016/j.ab.2004.04.032. PMID   15450800.
• Bonicalzi, M. -E.; Haince, J. -F.; Droit, A.; Poirier, G. G. (2005). "Poly-ADP-ribosylation in health and disease". Cellular and Molecular Life Sciences. 62 (7–8): 739–750. doi:10.1007/s00018-004-4505-1. PMC   11924541 . PMID   15868399.
• Bonicalzi, M. È.; Gagné, J. P.; Gagné, P.; Ouellet, M. È.; Hendzel, M. J.; Poirier, G. G. (2005). "Poly(ADP-ribose) glycohydrolase is a component of the FMRP-associated messenger ribonucleoparticles". Biochemical Journal. 392 (3): 499–509. doi:10.1042/BJ20050792. PMC   1316289 . PMID   16117724.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.