Phycocyanobilin:ferredoxin oxidoreductase

phycocyanobilin:ferredoxin oxidoreductase
Identifiers
EC no.	1.3.7.5
CAS no.	347401-12-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a phycocyanobilin:ferredoxin oxidoreductase (PcyA, EC 1.3.7.5) is an enzyme that catalyzes the chemical reaction

(3Z)-phycocyanobilin + oxidized ferredoxin ${\displaystyle \rightleftharpoons }$ biliverdin IXalpha + reduced ferredoxin

Thus, the two substrates of this enzyme are (3Z)-phycocyanobilin and oxidized ferredoxin, whereas its two products are biliverdin IXalpha and reduced ferredoxin.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with an iron-sulfur protein as acceptor. The systematic name of this enzyme class is (3Z)-phycocyanobilin:ferredoxin oxidoreductase. This enzyme participates in porphyrin and chlorophyll metabolism.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2D1E, 2DKE, and 2G18.

References

• Frankenberg N, Mukougawa K, Kohchi T, Lagarias JC (2001). "Functional genomic analysis of the HY2 family of ferredoxin-dependent bilin reductases from oxygenic photosynthetic organisms". Plant Cell. 13 (4): 965–78. doi:10.1105/tpc.13.4.965. PMC   135530 . PMID   11283349.
• Beale SI (1993). "Biosynthesis of phycobilins". Chem. Rev. 93 (2): 785–802. doi:10.1021/cr00018a008.
• Wu SH, McDowell MT, Lagarias JC (1997). "Phycocyanobilin is the natural precursor of the phytochrome chromophore in the green alga Mesotaenium caldariorum". J. Biol. Chem. 272 (41): 25700–5. doi: 10.1074/jbc.272.41.25700 . PMID   9325294.