SERPINB3

SERPINB3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ZV6, 4ZK0, 4ZK3
Identifiers
Aliases	SERPINB3 , HsT1196, SCC, SCCA-1, SCCA-PD, SCCA1, T4-A, SSCA1, serpin family B member 3
External IDs	OMIM: 600517; MGI: 2683295; HomoloGene: 130559; GeneCards: SERPINB3; OMA:SERPINB3 - orthologs
Gene location (Human) Chr. Chromosome 18 (human) [1] Band 18q21.33 Start 63,655,197 bp [1] End 63,661,893 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1 E2.1|1 Start 107,005,897 bp [2] End 107,011,236 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory zone of nasal mucosa nasal epithelium vulva human penis mucosa of paranasal sinus epithelium of bronchus bronchial epithelial cell gums gingival epithelium mucosa of pharynx Top expressed in thymus esophagus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function virus receptor activity protease binding cysteine-type endopeptidase inhibitor activity peptidase inhibitor activity serine-type endopeptidase inhibitor activity Cellular component nucleus vesicle cytoplasmic vesicle extracellular exosome cytoplasm extracellular region extracellular space azurophil granule lumen Biological process paracrine signaling positive regulation of cell population proliferation autocrine signaling negative regulation of catalytic activity negative regulation of JUN kinase activity positive regulation of endopeptidase activity positive regulation of epithelial to mesenchymal transition negative regulation of proteolysis negative regulation of endopeptidase activity positive regulation of cell migration viral entry into host cell negative regulation of peptidase activity neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6317 394252 Ensembl ENSG00000057149 ENSMUSG00000058017 UniProt P29508 Q6UKZ0 RefSeq (mRNA) NM_006919 NM_201376 RefSeq (protein) NP_008850 NP_958764 Location (UCSC) Chr 18: 63.66 – 63.66 Mb Chr 1: 107.01 – 107.01 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Serpin B3 is a protein that in humans is encoded by the SERPINB3 gene. ^{[5] [6]}

See also

• Serpin

References

1. GRCh38: Ensembl release 89: ENSG00000057149 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000058017 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Schneider SS, Schick C, Fish KE, Miller E, Pena JC, Treter SD, Hui SM, Silverman GA (May 1995). "A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene". Proc Natl Acad Sci U S A. 92 (8): 3147–51. Bibcode:1995PNAS...92.3147S. doi: 10.1073/pnas.92.8.3147 . PMC   42122 . PMID   7724531.
6. "Entrez Gene: SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3".

Further reading

• Suminami Y, Kishi F, Sekiguchi K, Kato H (1992). "Squamous cell carcinoma antigen is a new member of the serine protease inhibitors". Biochem. Biophys. Res. Commun. 181 (1): 51–8. doi:10.1016/S0006-291X(05)81380-4. PMID   1958219.
• Mino-Miyagawa N, Kimura Y, Hamamoto K (1990). "Tumor-antigen 4. Its immunohistochemical distribution and tissue and serum concentrations in squamous cell carcinoma of the lung and esophagus". Cancer. 66 (7): 1505–12. doi: 10.1002/1097-0142(19901001)66:7<1505::AID-CNCR2820660712>3.0.CO;2-V . PMID   2208001. S2CID   8673447.
• Mino N, Iio A, Hamamoto K (1988). "Availability of tumor-antigen 4 as a marker of squamous cell carcinoma of the lung and other organs". Cancer. 62 (4): 730–4. doi:10.1002/1097-0142(19880815)62:4<730::AID-CNCR2820620415>3.0.CO;2-W. PMID   2840187. S2CID   33396329.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Schick C, Pemberton PA, Shi GP, et al. (1998). "Cross-class inhibition of the cysteine proteinases cathepsins K, L, and S by the serpin squamous cell carcinoma antigen 1: a kinetic analysis". Biochemistry. 37 (15): 5258–66. doi:10.1021/bi972521d. PMID   9548757.
• Cataltepe S, Gornstein ER, Schick C, et al. (2000). "Co-expression of the squamous cell carcinoma antigens 1 and 2 in normal adult human tissues and squamous cell carcinomas". J. Histochem. Cytochem. 48 (1): 113–22. doi: 10.1177/002215540004800112 . PMID   10653592.
• Uemura Y, Pak SC, Luke C, et al. (2000). "Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells". Int. J. Cancer. 89 (4): 368–77. doi: 10.1002/1097-0215(20000720)89:4<368::AID-IJC9>3.0.CO;2-6 . PMID   10956412. S2CID   23697095.
• Hamada K, Shinomiya H, Asano Y, et al. (2001). "Molecular cloning of human squamous cell carcinoma antigen 1 gene and characterization of its promoter". Biochim. Biophys. Acta. 1518 (1–2): 124–31. doi:10.1016/s0167-4781(01)00174-9. PMID   11267667.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Shimada H, Nabeya Y, Okazumi S, et al. (2003). "Prediction of survival with squamous cell carcinoma antigen in patients with resectable esophageal squamous cell carcinoma". Surgery. 133 (5): 486–94. doi:10.1067/msy.2003.139. PMID   12773976.
• Micke O, Bruns F, Schäfer U, et al. (2003). "The clinical value of squamous cell carcinoma antigen in patients irradiated for locally advanced cancer of the head and neck". Anticancer Res. 23 (2A): 907–11. PMID   12820321.
• Nawata S, Nakamura K, Hirakawa H, et al. (2004). "Electrophoretic analysis of the cleaved form of serpin, squamous cell carcinoma antigen-1 in normal and malignant squamous epithelial tissues". Electrophoresis. 24 (14): 2277–82. doi:10.1002/elps.200305501. PMID   12874860. S2CID   41852542.
• Masumoto K, Sakata Y, Arima K, et al. (2003). "Inhibitory mechanism of a cross-class serpin, the squamous cell carcinoma antigen 1". J. Biol. Chem. 278 (46): 45296–304. doi: 10.1074/jbc.M307741200 . PMID   12949073.
• Moore PL, Ong S, Harrison TJ (2004). "Squamous cell carcinoma antigen 1-mediated binding of hepatitis B virus to hepatocytes does not involve the hepatic serpin clearance system". J. Biol. Chem. 278 (47): 46709–17. doi: 10.1074/jbc.M302842200 . PMID   12975381.
• Onishi A, Nakashiro K, Mihara M, et al. (2004). "Basic and clinical studies on quantitative analysis of lymph node micrometastasis in oral cancer". Oncol. Rep. 11 (1): 33–9. doi:10.3892/or.11.1.33. PMID   14654899.
• Hirakawa H, Nawata S, Sueoka K, et al. (2004). "Regulation of squamous cell carcinoma antigen production by E-cadherin mediated cell-cell adhesion in squamous cell carcinoma cell line". Oncol. Rep. 11 (2): 415–9. doi:10.3892/or.11.2.415. PMID   14719077.
• Pontisso P, Calabrese F, Benvegnù L, et al. (2004). "Overexpression of squamous cell carcinoma antigen variants in hepatocellular carcinoma". Br. J. Cancer. 90 (4): 833–7. doi:10.1038/sj.bjc.6601543. PMC   2410161 . PMID   14970861.
• Ruvoletto MG, Tono N, Carollo D, et al. (2004). "Surface expression of squamous cell carcinoma antigen (SCCA) can be increased by the preS1(21-47) sequence of hepatitis B virus". J. Gen. Virol. 85 (Pt 3): 621–4. doi: 10.1099/vir.0.19130-0 . hdl: 11577/2436607 . PMID   14993646.
• Turato, C; Ruvoletto, MG; Biasiolo, A; et al. (Mar 2009). "Squamous cell carcinoma antigen-1 (SERPINB3) polymorphism in chronic liver disease". Dig Liver Dis. 41 (3): 212–6. doi:10.1016/j.dld.2008.06.001. PMID   18657489.

External links

• The MEROPS online database for peptidases and their inhibitors: I04.008 ^{[ permanent dead link ]}
• SERPINB3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)