SERPINA9

SERPINA9
Identifiers
Aliases	SERPINA9 , GCET1, SERPINA11, SERPINA11b, serpin family A member 9
External IDs	OMIM: 615677; MGI: 1919157; HomoloGene: 23633; GeneCards: SERPINA9; OMA:SERPINA9 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q32.13 Start 94,462,717 bp [1] End 94,479,689 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12|12 E Start 103,961,002 bp [2] End 103,980,014 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in epithelium of nasopharynx testicle lymph node appendix superior surface of tongue oral cavity tonsil skin of abdomen skin of leg gonad Top expressed in striatum of neuraxis esophagus lip superior frontal gyrus exocrine gland liver visual cortex cerebellum cerebellar cortex primary visual cortex More reference expression data BioGPS n/a
Gene ontology Molecular function peptidase inhibitor activity serine-type endopeptidase inhibitor activity Cellular component extracellular region membrane cytoplasm extracellular space Biological process negative regulation of peptidase activity negative regulation of endopeptidase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 327657 71907 Ensembl ENSG00000170054 ENSMUSG00000058260 UniProt Q86WD7 Q9D7D2 RefSeq (mRNA) NM_001042518 NM_001284275 NM_001284276 NM_175739 NM_027997 NM_001361910 NM_001361912 RefSeq (protein) NP_001035983 NP_001271204 NP_001271205 NP_783866 NP_082273 NP_001348839 NP_001348841 Location (UCSC) Chr 14: 94.46 – 94.48 Mb Chr 12: 103.96 – 103.98 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Serpin A9 also known as centerin or GCET1 is a protein that in humans is encoded by the SERPINA9 gene located on chromosome 14q32.1. ^[5] Serpin A9 is a member of the serpin family of serine protease inhibitors.

Function

The expression of SERPINA9 is restricted to germinal center B cells and lymphoid malignancies. SERPINA9 is likely to function in vivo in the germinal center as an efficient inhibitor of trypsin-like proteases. ^{[6] [7] [8]}

References

1. GRCh38: Ensembl release 89: ENSG00000170054 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000058260 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: SERPINA9".
6. Paterson MA, Horvath AJ, Pike RN, Coughlin PB (August 2007). "Molecular characterization of centerin, a germinal centre cell serpin". Biochem. J. 405 (3): 489–94. doi:10.1042/BJ20070174. PMC   2267310 . PMID   17447896.
7. Montes-Moreno S, Roncador G, Maestre L, Martínez N, Sanchez-Verde L, Camacho FI, Cannata J, Martinez-Torrecuadrada JL, Shen Y, Chan WC, Piris MA (January 2008). "Gcet1 (centerin), a highly restricted marker for a subset of germinal center-derived lymphomas". Blood. 111 (1): 351–8. doi: 10.1182/blood-2007-06-094151 . PMID   17898315.
8. Paterson MA, Hosking PS, Coughlin PB (July 2008). "Expression of the serpin centerin defines a germinal center phenotype in B-cell lymphomas". Am. J. Clin. Pathol. 130 (1): 117–26. doi: 10.1309/9QKE68QU7B825A3U . PMID   18550480.

Further reading

• Luke MM, O'Meara ES, Rowland CM, et al. (2009). "Gene variants associated with ischemic stroke: the cardiovascular health study". Stroke. 40 (2): 363–8. doi:10.1161/STROKEAHA.108.521328. PMC   2881155 . PMID   19023099.
• Frazer JK, Jackson DG, Gaillard JP, et al. (2000). "Identification of centerin: a novel human germinal center B cell-restricted serpin". Eur. J. Immunol. 30 (10): 3039–48. doi: 10.1002/1521-4141(200010)30:10<3039::AID-IMMU3039>3.0.CO;2-H . PMID   11069088.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Morrison AC, Bare LA, Luke MM, et al. (2008). "Single nucleotide polymorphisms associated with coronary heart disease predict incident ischemic stroke in the atherosclerosis risk in communities study". Cerebrovasc. Dis. 26 (4): 420–4. doi:10.1159/000155637. PMC   2662496 . PMID   18799872.
• Shiffman D, O'Meara ES, Bare LA, et al. (2008). "Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study". Arterioscler. Thromb. Vasc. Biol. 28 (1): 173–9. doi:10.1161/ATVBAHA.107.153981. PMC   2636623 . PMID   17975119.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Montes-Moreno S, Roncador G, Maestre L, et al. (2008). "Gcet1 (centerin), a highly restricted marker for a subset of germinal center-derived lymphomas". Blood. 111 (1): 351–8. doi: 10.1182/blood-2007-06-094151 . PMID   17898315.
• Pan Z, Shen Y, Du C, et al. (2003). "Two newly characterized germinal center B-cell-associated genes, GCET1 and GCET2, have differential expression in normal and neoplastic B cells". Am. J. Pathol. 163 (1): 135–44. doi:10.1016/S0002-9440(10)63637-1. PMC   1868163 . PMID   12819018.
• Namciu SJ, Friedman RD, Marsden MD, et al. (2004). "Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1". Mamm. Genome. 15 (3): 162–78. doi:10.1007/s00335-003-2311-y. PMID   15014966. S2CID   8594824.

External links

• The MEROPS online database for peptidases and their inhibitors: I04.082 Archived 2012-12-23 at archive.today
• SERPINA9+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)