SERPINB7

SERPINB7
Identifiers
Aliases	SERPINB7 , MEGSIN, PPKN, TP55, serpin family B member 7
External IDs	OMIM: 603357; MGI: 2151053; HomoloGene: 68363; GeneCards: SERPINB7; OMA:SERPINB7 - orthologs
Gene location (Human) Chr. Chromosome 18 (human) [1] Band 18q21.33 Start 63,752,935 bp [1] End 63,805,376 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 E2.1 Start 107,327,385 bp [2] End 107,380,419 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of arm skin of leg human penis skin of abdomen skin of thigh skin of hip epithelium of nasopharynx vulva testicle bronchial epithelial cell Top expressed in skin of external ear umbilical cord skin of abdomen skin of back olfactory epithelium lip esophagus condyle fossa cervix More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase inhibitor activity serine-type endopeptidase inhibitor activity Cellular component cytoplasm extracellular space Biological process positive regulation of collagen biosynthetic process positive regulation of transforming growth factor beta1 production negative regulation of peptidase activity positive regulation of glomerular mesangial cell proliferation positive regulation of platelet-derived growth factor production negative regulation of endopeptidase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8710 116872 Ensembl ENSG00000166396 ENSMUSG00000067001 UniProt O75635 Q9D695 RefSeq (mRNA) NM_001040147 NM_001261830 NM_001261831 NM_003784 NM_027548 RefSeq (protein) NP_001035237 NP_001248759 NP_001248760 NP_003775 NP_081824 Location (UCSC) Chr 18: 63.75 – 63.81 Mb Chr 1: 107.33 – 107.38 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Serpin B7 is a protein that in humans is encoded by the SERPINB7 gene. ^[5]

See also

• Serpin

References

1. GRCh38: Ensembl release 89: ENSG00000166396 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000067001 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7".

Further reading

• Tsujimoto M, Tsuruoka N, Ishida N, et al. (1997). "Purification, cDNA cloning, and characterization of a new serpin with megakaryocyte maturation activity". J. Biol. Chem. 272 (24): 15373–80. doi: 10.1074/jbc.272.24.15373 . PMID   9182567.
• Miyata T, Nangaku M, Suzuki D, et al. (1998). "A mesangium-predominant gene, megsin, is a new serpin upregulated in IgA nephropathy". J. Clin. Invest. 102 (4): 828–36. doi:10.1172/JCI2450. PMC   508946 . PMID   9710452.
• Inagi R, Miyata T, Suzuki D, et al. (2001). "Specific tissue distribution of megsin, a novel serpin, in the glomerulus and its up-regulation in IgA nephropathy". Biochem. Biophys. Res. Commun. 286 (5): 1098–106. Bibcode:2001BBRC..286.1098I. doi:10.1006/bbrc.2001.5509. PMID   11527413.
• Inagi R, Miyata T, Imasawa T, et al. (2003). "Mesangial cell-predominant gene, megsin". Nephrol. Dial. Transplant. 17 Suppl 9 (90009): 32–3. doi: 10.1093/ndt/17.suppl_9.32 . PMID   12386281.
• Inagi R, Miyata T, Nangaku M, et al. (2003). "Transcriptional regulation of a mesangium-predominant gene, megsin" (PDF). J. Am. Soc. Nephrol. 13 (11): 2715–22. doi: 10.1097/01.ASN.0000033507.32175.FA . PMID   12397041.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Li YJ, Du Y, Li CX, et al. (2004). "Family-based association study showing that immunoglobulin A nephropathy is associated with the polymorphisms 2093C and 2180T in the 3' untranslated region of the Megsin gene". J. Am. Soc. Nephrol. 15 (7): 1739–43. doi: 10.1097/01.ASN.0000130858.00688.46 . PMID   15213261.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC   515316 . PMID   15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Inagi R, Nangaku M, Usuda N, et al. (2005). "Novel serpinopathy in rat kidney and pancreas induced by overexpression of megsin". J. Am. Soc. Nephrol. 16 (5): 1339–49. doi: 10.1681/ASN.2004070600 . PMID   15788472.
• Xia Y, Li Y, Du Y, et al. (2006). "Association of MEGSIN 2093C-2180T haplotype at the 3' untranslated region with disease severity and progression of IgA nephropathy". Nephrol. Dial. Transplant. 21 (6): 1570–4. doi:10.1093/ndt/gfk096. PMID   16431886.
• Xia YF, Huang S, Li X, et al. (2006). "A family-based association study of megsin A23167G polymorphism with susceptibility and progression of IgA nephropathy in a Chinese population". Clin. Nephrol. 65 (3): 153–9. doi:10.5414/cnp65153. PMID   16550745.

External links

• The MEROPS online database for peptidases and their inhibitors: I04.012 ^{[ permanent dead link ]}
• SERPINB7+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.