SERPINB4

SERPINB4
Identifiers
Aliases	SERPINB4 , LEUPIN, PI11, SCCA-2, SCCA1, SCCA2, serpin family B member 4
External IDs	OMIM: 600518; MGI: 3573933; HomoloGene: 76659; GeneCards: SERPINB4; OMA:SERPINB4 - orthologs
Gene location (Human) Chr. Chromosome 18 (human) [1] Band 18q21.33 Start 63,637,259 bp [1] End 63,644,256 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 E2.1 Start 106,973,317 bp [2] End 106,980,033 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nasal epithelium vulva mucosa of paranasal sinus human penis olfactory zone of nasal mucosa epithelium of bronchus bronchial epithelial cell gums gingival epithelium oral cavity Top expressed in esophagus superior surface of tongue skin of external ear lip conjunctival fornix trachea secondary oocyte molar zygote corneal stroma More reference expression data BioGPS n/a
Gene ontology Molecular function peptidase inhibitor activity protease binding enzyme binding serine-type endopeptidase inhibitor activity Cellular component cytoplasm intracellular anatomical structure extracellular space Biological process negative regulation of peptidase activity regulation of proteolysis protection from natural killer cell mediated cytotoxicity negative regulation of endopeptidase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6318 20248 Ensembl ENSG00000206073 ENSMUSG00000044594 UniProt P48594 n/a RefSeq (mRNA) NM_002974 NM_175041 NM_009126 RefSeq (protein) NP_002965 NP_778206 n/a Location (UCSC) Chr 18: 63.64 – 63.64 Mb Chr 1: 106.97 – 106.98 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Serpin B4 is a protein that in humans is encoded by the SERPINB4 gene. ^{[5] [6] [7]}

See also

• Serpin

References

1. GRCh38: Ensembl release 89: ENSG00000206073 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000044594 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Schneider SS, Schick C, Fish KE, Miller E, Pena JC, Treter SD, Hui SM, Silverman GA (May 1995). "A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene". Proc Natl Acad Sci U S A. 92 (8): 3147–51. Bibcode:1995PNAS...92.3147S. doi: 10.1073/pnas.92.8.3147 . PMC   42122 . PMID   7724531.
6. Sakata Y, Arima K, Takai T, Sakurai W, Masumoto K, Yuyama N, Suminami Y, Kishi F, Yamashita T, Kato T, Ogawa H, Fujimoto K, Matsuo Y, Sugita Y, Izuhara K (Feb 2004). "The squamous cell carcinoma antigen 2 inhibits the cysteine proteinase activity of a major mite allergen, Der p 1". J Biol Chem. 279 (7): 5081–7. doi: 10.1074/jbc.M311585200 . PMID   14630915.
7. "Entrez Gene: SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4".

Further reading

• Barnes RC, Worrall DM (1995). "Identification of a novel human serpin gene; cloning sequencing and expression of leupin". FEBS Letters. 373 (1): 61–5. Bibcode:1995FEBSL.373...61B. doi: 10.1016/0014-5793(95)01015-7 . PMID   7589435. S2CID   26092255.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Bartuski AJ, Kamachi Y, Schick C, et al. (1999). "A murine ortholog of the human serpin SCCA2 maps to chromosome 1 and inhibits chymotrypsin-like serine proteinases". Genomics. 54 (2): 297–306. doi:10.1006/geno.1998.5586. PMID   9828132.
• Sakaguchi Y, Kishi F, Murakami A, et al. (1999). "Structural analysis of human SCC antigen 2 promoter". Biochim. Biophys. Acta. 1444 (1): 111–6. doi:10.1016/s0167-4781(98)00259-0. PMID   9931463.
• Cataltepe S, Gornstein ER, Schick C, et al. (2000). "Co-expression of the squamous cell carcinoma antigens 1 and 2 in normal adult human tissues and squamous cell carcinomas". J. Histochem. Cytochem. 48 (1): 113–22. doi: 10.1177/002215540004800112 . PMID   10653592.
• Luke C, Schick C, Tsu C, et al. (2000). "Simple modifications of the serpin reactive site loop convert SCCA2 into a cysteine proteinase inhibitor: a critical role for the P3' proline in facilitating RSL cleavage". Biochemistry. 39 (24): 7081–91. doi:10.1021/bi000050g. PMID   10852705.
• Uemura Y, Pak SC, Luke C, et al. (2000). "Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells". Int. J. Cancer. 89 (4): 368–77. doi: 10.1002/1097-0215(20000720)89:4<368::AID-IJC9>3.0.CO;2-6 . PMID   10956412. S2CID   23697095.
• Hamada K, Shinomiya H, Asano Y, et al. (2001). "Molecular cloning of human squamous cell carcinoma antigen 1 gene and characterization of its promoter". Biochim. Biophys. Acta. 1518 (1–2): 124–31. doi:10.1016/s0167-4781(01)00174-9. PMID   11267667.
• Takeda A, Kajiya A, Iwasawa A, et al. (2003). "Aberrant expression of serpin squamous cell carcinoma antigen 2 in human tumor tissues and cell lines: evidence of protection from tumor necrosis factor-mediated apoptosis". Biol. Chem. 383 (7–8): 1231–6. doi:10.1515/BC.2002.136. PMID   12437110. S2CID   23972588.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gariboldi M, Peissel B, Fabbri A, et al. (2003). "SCCA2-like serpins mediate genetic predisposition to skin tumors". Cancer Res. 63 (8): 1871–5. PMID   12702576.
• Pontisso P, Calabrese F, Benvegnù L, et al. (2004). "Overexpression of squamous cell carcinoma antigen variants in hepatocellular carcinoma". Br. J. Cancer. 90 (4): 833–7. doi:10.1038/sj.bjc.6601543. PMC   2410161 . PMID   14970861.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ray R, Choi M, Zhang Z, et al. (2005). "Uteroglobin suppresses SCCA gene expression associated with allergic asthma". J. Biol. Chem. 280 (11): 9761–4. doi: 10.1074/jbc.C400581200 . PMID   15677460.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Sueoka K, Nawata S, Nakagawa T, et al. (2005). "Tumor-associated serpin, squamous cell carcinoma antigen stimulates matrix metalloproteinase-9 production in cervical squamous cell carcinoma cell lines". Int. J. Oncol. 27 (5): 1345–53. doi:10.3892/ijo.27.5.1345. PMID   16211231.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Katagiri C, Nakanishi J, Kadoya K, Hibino T (2006). "Serpin squamous cell carcinoma antigen inhibits UV-induced apoptosis via suppression of c-JUN NH2-terminal kinase". J. Cell Biol. 172 (7): 983–90. doi:10.1083/jcb.200508064. PMC   2063756 . PMID   16549498.

External links

• The MEROPS online database for peptidases and their inhibitors: I04.009 ^{[ permanent dead link ]}
• SERPINB4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)