SERPINB9

SERPINB9
Identifiers
Aliases	SERPINB9 , CAP-3, CAP3, PI-9, PI9, serpin family B member 9
External IDs	OMIM: 601799; MGI: 106603; HomoloGene: 37888; GeneCards: SERPINB9; OMA:SERPINB9 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p25.2 Start 2,887,270 bp [1] End 2,903,309 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13 A3.2- A3.3|13 13.79 cM Start 33,187,233 bp [2] End 33,201,940 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in epithelium of nasopharynx mononuclear cell monocyte germinal epithelium appendix lymph node placenta tibial nerve blood granulocyte Top expressed in right lung lobe gastrula left lung mesenteric lymph nodes left lung lobe placenta lumbar spinal ganglion Epithelium of choroid plexus carotid body spleen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase inhibitor activity cysteine-type endopeptidase inhibitor activity involved in apoptotic process protease binding protein binding serine-type endopeptidase inhibitor activity Cellular component cytosol membrane intracellular anatomical structure extracellular exosome nucleus cytoplasm extracellular space nucleoplasm Golgi apparatus collagen-containing extracellular matrix Biological process negative regulation of peptidase activity mast cell mediated immunity negative regulation of apoptotic process protection from natural killer cell mediated cytotoxicity cellular response to estrogen stimulus positive regulation of gene expression negative regulation by symbiont of host apoptotic process immune response negative regulation of endopeptidase activity apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5272 20723 Ensembl ENSG00000170542 ENSMUSG00000045827 UniProt P50453 O08797 RefSeq (mRNA) NM_004155 NM_009256 RefSeq (protein) NP_004146 NP_004146.1 NP_033282 Location (UCSC) Chr 6: 2.89 – 2.9 Mb Chr 13: 33.19 – 33.2 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Serpin B9 is a protein that in humans is encoded by the SERPINB9 gene. ^{[5] [6] [7]} Serpin B9 is an inhibitor of Granzyme B (GzmB). GzmB is a potent cytotoxic molecule that is secreted by cytotoxic T lymphocytes and natural killer (NK) cells to induce apoptosis in target cells during an immune response. Serpin B9, expressed in the cytosol and nucleus, thus protects from apoptosis by cytotoxic T lymphocytes and NK cells. ^[8]

Serpin B9 belongs to the large superfamily of serine proteinase inhibitors (serpins), which bind to and inactivate serine proteinases. These interactions are involved in many cellular processes, including coagulation, fibrinolysis, complement fixation, matrix remodeling, and apoptosis (Sprecher et al., 1995).[supplied by OMIM] ^[7]

See also

• Serpin

References

1. GRCh38: Ensembl release 89: ENSG00000170542 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000045827 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sprecher CA, Morgenstern KA, Mathewes S, Dahlen JR, Schrader SK, Foster DC, Kisiel W (Jan 1996). "Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors". J Biol Chem. 270 (50): 29854–61. doi: 10.1074/jbc.270.50.29854 . PMID   8530382.
6. Sun J, Stephens R, Mirza G, Kanai H, Ragoussis J, Bird PI (Feb 1999). "A serpin gene cluster on human chromosome 6p25 contains PI6, PI9 and ELANH2 which have a common structure almost identical to the 18q21 ovalbumin serpin genes". Cytogenet Cell Genet. 82 (3–4): 273–7. doi:10.1159/000015118. PMID   9858835. S2CID   23659776.
7. "Entrez Gene: SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9".
8. Huang H, Mu Y, Li S (2024). "The biological function of Serpinb9 and Serpinb9-based therapy". Frontiers in Immunology. 15. doi: 10.3389/fimmu.2024.1422113 . PMC   11222584 . PMID   38966643.

Further reading

• Sun J, Bird CH, Sutton V, et al. (1996). "A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes". J. Biol. Chem. 271 (44): 27802–9. doi: 10.1074/jbc.271.44.27802 . PMID   8910377.
• Annand RR, Dahlen JR, Sprecher CA, et al. (1999). "Caspase-1 (interleukin-1beta-converting enzyme) is inhibited by the human serpin analogue proteinase inhibitor 9". Biochem. J. 342 Pt 3 (3): 655–65. doi:10.1042/0264-6021:3420655. PMC   1220507 . PMID   10477277.
• Kanamori H, Krieg S, Mao C, et al. (2000). "Proteinase inhibitor 9, an inhibitor of granzyme B-mediated apoptosis, is a primary estrogen-inducible gene in human liver cells". J. Biol. Chem. 275 (8): 5867–73. doi: 10.1074/jbc.275.8.5867 . PMID   10681578.
• Bladergroen BA, Strik MC, Bovenschen N, et al. (2001). "The granzyme B inhibitor, protease inhibitor 9, is mainly expressed by dendritic cells and at immune-privileged sites". J. Immunol. 166 (5): 3218–25. doi: 10.4049/jimmunol.166.5.3218 . PMID   11207275.
• Buzza MS, Hirst CE, Bird CH, et al. (2001). "The granzyme B inhibitor, PI-9, is present in endothelial and mesothelial cells, suggesting that it protects bystander cells during immune responses". Cell. Immunol. 210 (1): 21–9. doi:10.1006/cimm.2001.1806. PMID   11485349.
• Hirst CE, Buzza MS, Sutton VR, et al. (2002). "Perforin-independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B-mediated proteolysis in reproduction". Mol. Hum. Reprod. 7 (12): 1133–42. doi: 10.1093/molehr/7.12.1133 . PMID   11719590.
• Tanaka K, Harashima N, Niiya F, et al. (2002). "Serine proteinase inhibitor 9 can be recognized by cytotoxic T lymphocytes of epithelial cancer patients". Jpn. J. Cancer Res. 93 (2): 198–208. doi:10.1111/j.1349-7006.2002.tb01259.x. PMC   5926951 . PMID   11856484.
• ten Berge RL, Meijer CJ, Dukers DF, et al. (2002). "Expression levels of apoptosis-related proteins predict clinical outcome in anaplastic large cell lymphoma". Blood. 99 (12): 4540–6. doi: 10.1182/blood.V99.12.4540 . PMID   12036886.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Hirst CE, Buzza MS, Bird CH, et al. (2003). "The intracellular granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell degranulation, and its overexpression enhances CTL potency". J. Immunol. 170 (2): 805–15. doi: 10.4049/jimmunol.170.2.805 . PMID   12517944.
• Rowshani AT, Florquin S, Bemelman F, et al. (2005). "Hyperexpression of the granzyme B inhibitor PI-9 in human renal allografts: a potential mechanism for stable renal function in patients with subclinical rejection". Kidney Int. 66 (4): 1417–22. doi: 10.1111/j.1523-1755.2004.00903.x . PMID   15458434.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Mahrus S, Kisiel W, Craik CS (2005). "Granzyme M is a regulatory protease that inactivates proteinase inhibitor 9, an endogenous inhibitor of granzyme B". J. Biol. Chem. 279 (52): 54275–82. doi: 10.1074/jbc.M411482200 . PMID   15494398.
• Classen CF, Ushmorov A, Bird P, Debatin KM (2006). "The granzyme B inhibitor PI-9 is differentially expressed in all main subtypes of pediatric acute lymphoblastic leukemias". Haematologica. 89 (11): 1314–21. PMID   15531453.
• Bruneel A, Labas V, Mailloux A, et al. (2006). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis". Proteomics. 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID   16130169. S2CID   26007149.
• van Houdt IS, Oudejans JJ, van den Eertwegh AJ, et al. (2005). "Expression of the apoptosis inhibitor protease inhibitor 9 predicts clinical outcome in vaccinated patients with stage III and IV melanoma". Clin. Cancer Res. 11 (17): 6400–7. doi: 10.1158/1078-0432.CCR-05-0306 . PMID   16144945.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID   16169070. S2CID   8235923.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.

External links

• The MEROPS online database for peptidases and their inhibitors: I04.014 ^{[ permanent dead link ]}
• SERPINB9+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.