Aristolochic acids are a family of carcinogenic, mutagenic, and nephrotoxic phytochemicals commonly found in the flowering plant family Aristolochiaceae (birthworts). Aristolochic acid (AA) I is the most abundant one. The family Aristolochiaceae includes the genera Aristolochia and Asarum, which are commonly used in Chinese herbal medicine. Although these compounds are widely associated with kidney problems, liver and urothelial cancers, the use of AA-containing plants for medicinal purposes has a long history. The FDA has issued warnings regarding consumption of AA-containing supplements.
Chinese herbology is the theory of traditional Chinese herbal therapy, which accounts for the majority of treatments in traditional Chinese medicine (TCM). A Nature editorial described TCM as "fraught with pseudoscience", and said that the most obvious reason why it has not delivered many cures is that the majority of its treatments have no logical mechanism of action.
Aristolochia is a large plant genus with over 500 species that is the type genus of the family Aristolochiaceae. Its members are commonly known as birthwort, pipevine or Dutchman's pipe and are widespread and occur in the most diverse climates. Some species, like A. utriformis and A. westlandii, are threatened with extinction.
Angelica sinensis, commonly known as dong quai or female ginseng, is a herb belonging to the family Apiaceae, indigenous to China. Angelica sinensis grows in cool high altitude mountains in East Asia. The yellowish brown root of the plant is harvested in the fall and is a well-known Chinese medicine which has been used for thousands of years.
Aristolochia californica, the California pipevine, California Dutchman's-pipe, or California snakeroot is a perennial woody vine of western North America.
Glycyrrhiza uralensis, also known as Chinese liquorice, is a flowering plant native to Asia. It is used as a sweetener and in traditional Chinese medicine.
Balkan endemic nephropathy (BEN) is a form of interstitial nephritis causing kidney failure. It was first identified in the 1920s among several small, discrete communities along the Danube River and its major tributaries, in the modern countries of Croatia, Bosnia and Herzegovina, Serbia, Kosovo, Romania, and Bulgaria. It is caused by small long-term doses of aristolochic acid in the diet. The disease primarily affects people 30 to 60 years of age. Doses of the toxin are usually low and people moving to endemic areas typically develop the condition only when they have lived there for 10–20 years. People taking higher doses of aristolochic acid have developed kidney failure after shorter durations of exposure.
Aristolochia clematitis, the (European) birthwort, is a twining herbaceous plant in the family Aristolochiaceae, which is native to Europe. The leaves are heart shaped and the flowers are pale yellow and tubular in form. The plant seeks light by ascending the stems of surrounding plants.
Stephania is a genus of flowering plants in the family Menispermaceae, native to eastern and southern Asia and Australia. They are herbaceous perennial vines, growing to around four metres tall, with a large tuber. The leaves are arranged spirally on the stem and are peltate, with the leaf petiole attached near the centre of the leaf. The name Stephania comes from the Greek, "a crown". This refers to the anthers being arranged in a crown-like manner.
Aristolochia grandiflora, the pelican flower, is a deciduous vine with one of the world's largest flowers that emits an odor that smells like rotting meat, attracting flies.
Tetrandrine, a bis-benzylisoquinoline alkaloid, is a calcium channel blocker. It is isolated from the plant Stephania tetrandra, and other Chinese and Japanese herbs.
Lindera aggregata is a plant species belonging to the genus Lindera.
Huáng bǎi, huáng bó or huáng bò is one of the fifty fundamental herbs of traditional Chinese medicine. Known also as Cortex Phellodendri, it is the bark of one of two species of Phellodendron tree: Phellodendron amurense or Phellodendron chinense.
Achyranthes bidentata Blume is a species of flowering plant in the amaranth family, Amaranthaceae. It occurs in India, Nepal, Korea, China, and Japan. It is the source of the Chinese herbal medicine Huai'niuxi(Chinese: 怀牛膝; pinyin: Huái'niúxī). In Nepal its root juice is used for toothache. Its seeds have been used as a substitute for cereal grains in famine years. The plant is used externally in the treatment of leech bites in Mizoram, India and a decoction as a diuretic.
Aristolochia didyma, or yawar panga is a plant found in South America of the genus Aristolochia. It is a powerful purgative, sometimes used in traditional rites to purify the body a few days before an Ayahuasca session.
Tetradium ruticarpum is a tree that comes from China and Korea. It was previously classified in the genus Euodia as Euodia ruticarpa. The fruit is usually used, denoted sometimes as fructus. It has a strong bitter taste, and is used in traditional Chinese medicine (TCM) and is a recognized herb in Kampo. Both the former genus name and the species name are often misspelled, and the plant usually appears in sources dealing with traditional Chinese medicine as "Evodia(e) rutaecarpa".
Aristolochia paucinervis is a herbaceous plant in the family Aristolochiaceae endemic to the western Mediterranean Basin.
Aristolochia fangchi, is a species of flowering plant in the family Aristolochiaceae, native to Vietnam and southeast and south-central China.
