Sulfinoalanine decarboxylase

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Sulfinoalanine decarboxylase
2jis.jpg
Cysteine sulfinic acid decarboxylase homodimer, Human
Identifiers
EC no. 4.1.1.29
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
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PMC articles
PubMed articles
NCBI proteins

The enzyme sulfinoalanine decarboxylase (EC 4.1.1.29) catalyzes the chemical reaction

3-sulfino-L-alanine hypotaurine + CO2

Hence, this enzyme has one substrate, 3-sulfino-L-alanine (also known as Cysteine sulfinic acid), and two products, hypotaurine and CO2.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 3-sulfino-L-alanine carboxy-lyase (hypotaurine-forming). Other names in common use include cysteine-sulfinate decarboxylase, L-cysteinesulfinic acid decarboxylase, cysteine-sulfinate decarboxylase, CADCase/CSADCase, CSAD, cysteic decarboxylase, cysteinesulfinic acid decarboxylase, cysteinesulfinate decarboxylase, sulfoalanine decarboxylase, and 3-sulfino-L-alanine carboxy-lyase. This enzyme participates in taurine metabolism. It employs one cofactor, pyridoxal phosphate.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2JIS.

Related Research Articles

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References