Tabernaemontana divaricata

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Tabernaemontana divaricata
Crape Jasmine.jpg
Scientific classification OOjs UI icon edit-ltr.svg
Kingdom: Plantae
Clade: Tracheophytes
Clade: Angiosperms
Clade: Eudicots
Clade: Asterids
Order: Gentianales
Family: Apocynaceae
Genus: Tabernaemontana
Species:
T. divaricata
Binomial name
Tabernaemontana divaricata
R.Br. ex Roem. & Schult.
Synonyms [2]
List
    • Ervatamia coronaria(Jacq.) Stapf
    • Ervatamia divaricata(L.) Burkill
    • Ervatamia divaricata var. plena(Roxb. ex Voigt) M.R.Almeida
    • Ervatamia flabelliformisTsiang
    • Ervatamia recurva(Lindl.) Lace
    • Ervatamia siamensis(Warb. ex Pit.) Kerr
    • Kopsia cochinchinensisKuntze
    • Nerium coronariumJacq.
    • Nerium divaricatumL.
    • Reichardia grandifloraDennst.
    • Reichardia jasminoidesDennst.
    • Taberna discolor(Sw.) Miers
    • Tabernaemontana citrifoliaLunan
    • Tabernaemontana coronaria(Jacq.) Willd.
    • Tabernaemontana discolorSw.
    • Tabernaemontana flabelliformis(Tsiang) P.T.Li
    • Tabernaemontana gratissimaLindl.
    • Tabernaemontana luridaVan Heurck & Müll.Arg.
    • Tabernaemontana recurvaLindl.
    • Tabernaemontana siamensisWarb. ex Pit.
    • Testudipes recurva(Lindl.) Markgr.
    • Vinca albaNoronha
    • Jasminum zeylanicumBurm.f.
    • Nyctanthes acuminataBurm.f.

Tabernaemontana divaricata, commonly called pinwheel flower, [3] crape jasmine, East India rosebay, and Nero's crown, [4] is an evergreen shrub or small tree native to South Asia, Southeast Asia and China. [1] In zones where it is not hardy it is grown as a house/glasshouse plant for its attractive flowers and foliage. The stem exudes a milky latex when broken, whence comes the name milk flower

Contents

Flowers in West Bengal, India. Crape jasmine flowers in West Bengal.jpg
Flowers in West Bengal, India.

Description

The plant generally grows to a height of 1.5–1.8 metres (5–6 ft) and is dichotomously branched. The large shiny leaves are deep green and about 15 cm (6 in) in length and 5 cm (2 in) in width. The waxy blossoms are found in small clusters on the stem tips. The (single) flowers have the characteristic 'pinwheel' shape also seen in other genera in the family Apocynaceae such as Vinca and Nerium . Both single and double-flowered forms are cultivated, the flowers of both forms being white. The plant blooms in spring but flowers appear sporadically all year. The flowers have a pleasing fragrance. [5] More than 66 alkaloids are found in the shrub. [6] Its habitats include montane brushwoods and sparse forests. [7]

Phytochemistry

The species is known to produce many alkaloids including catharanthine, coronaridine, dregamine, ibogamine, tabersonine, voacangine, voacamine and voacristine. [8] Ibogaine may occur in multiple Tabernaemontana species. [8]

Research

There is presence of potent acetylcholinestearase inhibitors in stems and roots of this plant. 3'-R/S-hydroxyvoacamine isolated from a stem extracts act as a non-competitive inhibitor against AChE with an IC50 value of 7.00±1.99 μM. [9] Bisindole alkaloid 19,20-dihydrotabernamine and 19,20-Dihydroervahanine A shows higher inhibitory activity on acetylcholinesterase compared with galanthamine. [10]

See also

Related Research Articles

<span class="mw-page-title-main">Jasmine</span> Genus of flowering plant in the olive family Oleaceae

Jasmine is a genus of shrubs and vines in the olive family of Oleaceae. It contains around 200 species native to tropical and warm temperate regions of Eurasia, Africa, and Oceania. Jasmines are widely cultivated for the characteristic fragrance of their flowers. Additionally a number of unrelated species of plants or flowers contain the word "jasmine" in their common names.

<span class="mw-page-title-main">Apocynaceae</span> Dogbane and oleander family of flowering plants

Apocynaceae is a family of flowering plants that includes trees, shrubs, herbs, stem succulents, and vines, commonly known as the dogbane family, because some taxa were used as dog poison. Members of the family are native to the European, Asian, African, Australian, and American tropics or subtropics, with some temperate members. The former family Asclepiadaceae is considered a subfamily of Apocynaceae and contains 348 genera. A list of Apocynaceae genera may be found here.

<i>Tabernaemontana</i> Genus of plants

Tabernaemontana is a genus of flowering plants in the family Apocynaceae. It has a pan-tropical distribution, found in Asia, Africa, Australia, North America, South America, and a wide assortment of oceanic islands. These plants are evergreen shrubs and small trees growing to 1–15 m tall. The leaves are opposite, 3–25 cm long, with milky sap; hence it is one of the diverse plant genera commonly called "milkwood". The flowers are fragrant, white, 1–5 cm in diameter.

<span class="mw-page-title-main">Voacangine</span> Chemical compound

Voacangine is an alkaloid found predominantly in the root bark of the Voacanga africana tree, as well as in other plants such as Tabernanthe iboga, Tabernaemontana africana, Trachelospermum jasminoides, Tabernaemontana divaricata and Ervatamia yunnanensis. It is an iboga alkaloid which commonly serves as a precursor for the semi-synthesis of ibogaine. It has been demonstrated in animals to have similar anti-addictive properties to ibogaine itself. It also potentiates the effects of barbiturates. Under UV-A and UV-B light its crystals fluoresce blue-green, and it is soluble in ethanol.

<span class="mw-page-title-main">Indole alkaloid</span> Class of alkaloids

Indole alkaloids are a class of alkaloids containing a structural moiety of indole; many indole alkaloids also include isoprene groups and are thus called terpene indole or secologanin tryptamine alkaloids. Containing more than 4100 known different compounds, it is one of the largest classes of alkaloids. Many of them possess significant physiological activity and some of them are used in medicine. The amino acid tryptophan is the biochemical precursor of indole alkaloids.

<i>Tabernaemontana corymbosa</i> Species of plant

Tabernaemontana corymbosa is a species of plant in the family Apocynaceae. It is found in Brunei, China, Indonesia, Laos, Malaysia, Myanmar, Singapore, Thailand, and Vietnam. Glossy green leaves and faintly sweet scented flower. Flowers continuously all year. Frost tolerant. Grows to about 2 metres. Likes full sun to part shade. A number of cultivars are available.

<span class="mw-page-title-main">Coronaridine</span> Chemical compound

Coronaridine, also known as 18-carbomethoxyibogamine, is an alkaloid found in Tabernanthe iboga and related species, including Tabernaemontana divaricata for which it was named.

<span class="mw-page-title-main">Ibogamine</span> Anti-convulsant, anti-addictive CNS stimulant alkaloid

Ibogamine is an anti-convulsant, anti-addictive, CNS stimulant alkaloid found in Tabernanthe iboga and Crepe Jasmine. Basic research related to how addiction affects the brain has used this chemical.

<span class="mw-page-title-main">Conolidine</span> Chemical compound

Conolidine is an indole alkaloid. Preliminary reports suggest that it could provide analgesic effects with few of the detrimental side-effects associated with opioids such as morphine, though at present it has only been evaluated in mouse models.

<span class="mw-page-title-main">Tabernamine</span> Chemical compound

Tabernamine is a bisindole isolate of Tabernaemontana with anticancer activity.

<span class="mw-page-title-main">Catharanthine</span> Chemical compound

Catharanthine is a terpene indole alkaloid produced by the medicinal plant Catharanthus roseus and Tabernaemontana divaricata. Catharanthine is derived from strictosidine, but the exact mechanism by which this happens is currently unknown. Catharanthine is one of the two precursors that form vinblastine, the other being vindoline.

<span class="mw-page-title-main">Affinine</span> Chemical compound

Affinine is a monoterpenoid indole alkaloid which can be isolated from plants of the genus Tabernaemontana. Structurally it can be considered a member of the vobasine alkaloid family and may be synthesized from tryptophan. Limited pharmacological testing has indicated that it may be an effective inhibitor of both acetylcholinesterase and butyrylcholinesterase.

<span class="mw-page-title-main">Affinisine</span> Chemical compound

Affinisine is a monoterpenoid indole alkaloid which can be isolated from plants of the genus Tabernaemontana. Structurally, it can be considered a member of the sarpagine alkaloid family and may be synthesized from tryptophan via a Pictet-Spengler reaction.

<span class="mw-page-title-main">Apparicine</span> Chemical compound

Apparicine is a monoterpenoid indole alkaloid. It is named after Apparicio Duarte, a Brazilian botanist who studied the Aspidosperma species from which apparicine was first isolated. It was the first member of the vallesamine group of alkaloids to be isolated and have its structure established, which was first published in 1965. It has also been known by the synonyms gomezine, pericalline, and tabernoschizine.

<span class="mw-page-title-main">Ibogaline</span> Alkaloid found in Tabernanthe iboga

Ibogaline is an alkaloid found in Tabernanthe iboga along with the related chemical compounds ibogaine, ibogamine, and other minor alkaloids. It is a relatively smaller component of Tabernanthe iboga root bark total alkaloids (TA) content. It is also present in Tabernaemontana species such as Tabernaemontana australis which shares similar ibogan-biosynthetic pathways. The percentage of ibogaline in T. iboga root bark is up to 15% TA with ibogaine constituting 80% of the alkaloids and ibogamine up to 5%.

<span class="mw-page-title-main">Tabernaemontanine</span> Chemical compound

Tabernaemontanine is a naturally occurring monoterpene indole alkaloid found in several species in the genus Tabernaemontana including Tabernaemontana divaricata.

<span class="mw-page-title-main">Dregamine</span> Chemical compound

Dregamine is a naturally occurring monoterpene indole alkaloid found in several species in the genus Tabernaemontana including Ervatamia hirta and Tabernaemontana divaricata.

<span class="mw-page-title-main">Conophylline</span> Chemical compound

Conophylline is a autophagy inducing vinca alkaloid found in several species of Tabernaemontana including Ervatamia microphylla and Tabernaemontana divaricata. Among its many functional groups is an epoxide: the compound where that ring is replaced with a double bond is called conophyllidine and this co-occurs in the same plants.

<span class="mw-page-title-main">Vobasine</span> Chemical compound

Vobasine is a naturally occurring monoterpene indole alkaloid found in several species in the genus Tabernaemontana including Tabernaemontana divaricata.

<span class="mw-page-title-main">19,20-Dihydroervahanine A</span> Chemical compound

19,20-Dihydroervahanine A is an alkaloid, a natural product which is found in the root of the South-East Asian plant Tabernaemontana divaricata. It inhibits acetylcholinesterase more potently than galantamine in vitro.

References

  1. 1 2 Lakhey, P.; Pathak, J. (2020). "crape jasmine". IUCN Red List of Threatened Species . 2020: e.T149853146A149853842. doi: 10.2305/IUCN.UK.2020-3.RLTS.T149853146A149853842.en . Retrieved 19 November 2021.
  2. "Tabernaemontana divaricata (L.) R.Br. ex Roem. & Schult". Plants of the World Online. Board of Trustees of the Royal Botanic Gardens, Kew. 2017. Retrieved 7 September 2020.
  3. USDA, NRCS (n.d.). "Tabernaemontana divaricata". The PLANTS Database (plants.usda.gov). Greensboro, North Carolina: National Plant Data Team. Retrieved 7 December 2015.
  4. Medicinal Plants of India and Pakistan, Dastur J.F., pub.1962 by D.P. Taraporevala Sons and Co. Private Ltd., Mumbai, 4th Indian reprint 1977[ page needed ]
  5. The Royal Horticultural Society Dictionary of Gardening ed. Chittenden,Fred J. 2nd ed. by Synge,Patrick M. Volume IV : Pt-Zy, p.2074 (as T. coronaria). Pub. Oxford at the Clarendon Press 1965. Reprinted 1984. ISBN   0-19-869106-8
  6. Perry, Lily M. (1980). Medicinal Plants of East and Southeast Asia: Attributed Properties and Uses . MIT Press. ISBN   978-0-262-16076-6.[ page needed ]
  7. "Tabernaemontana divaricata in Flora of China @ efloras.org". www.efloras.org. Retrieved 2022-09-27.
  8. 1 2 Kam TS, Pang HS, Choo YM, Komiyama K (April 2004). "Biologically active ibogan and vallesamine derivatives from Tabernaemontana divaricata". Chemistry and Biodiversity. 1 (4): 646–56. doi:10.1002/cbdv.200490056. PMID   17191876. S2CID   12805328.
  9. Chaiyana W, Schripsema J, Ingkaninan K, Okonogi S (April 2013). "3'-R/S-hydroxyvoacamine, a potent acetylcholinesterase inhibitor from Tabernaemontana divaricata". Phytomedicine . 20 (6): 543–8. doi:10.1016/j.phymed.2012.12.016. PMID   23375813.
  10. Ingkaninan K, Changwijit K, Suwanborirux K (June 2006). "Vobasinyl-iboga bisindole alkaloids, potent acetylcholinesterase inhibitors from Tabernaemontana divaricata root". The Journal of Pharmacy and Pharmacology . 58 (6): 847–52. doi: 10.1211/jpp.58.6.0015 . PMID   16734986. S2CID   37975644.