Trans-feruloyl-CoA hydratase

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trans-feruloyl-CoA hydratase
Identifiers
EC no. 4.2.1.101
CAS no. 197462-62-7
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
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In enzymology, a trans-feruloyl-CoA hydratase (EC 4.2.1.101) is an enzyme that catalyzes the chemical reaction

4-hydroxy-3-methoxyphenyl-beta-hydroxypropanoyl-CoA trans-feruloyl-CoA + H2O

Hence, this enzyme has one substrate, 4-hydroxy-3-methoxyphenyl-beta-hydroxypropanoyl-CoA, and two products, trans-feruloyl-CoA and H2O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 4-hydroxy-3-methoxyphenyl-beta-hydroxypropanoyl-CoA hydro-lyase (trans-feruloyl-CoA-forming). This enzyme is also called trans-feruloyl-CoA hydro-lyase (incorrect).

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2J5I.

Related Research Articles

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In enzymology, a vanillin synthase is an enzyme that catalyzes the chemical reaction

In enzymology, a trans-feruloyl—CoA synthase is an enzyme that catalyzes the chemical reaction

The enzyme 3α,7α,12α-trihydroxy-5β-cholest-24-enoyl-CoA hydratase (EC 4.2.1.107) catalyzes the chemical reaction

<span class="mw-page-title-main">3-dehydroquinate dehydratase</span> Class of enzymes

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<span class="mw-page-title-main">Hydroxymethylglutaryl-CoA synthase</span> Class of enzymes

In molecular biology, hydroxymethylglutaryl-CoA synthase or HMG-CoA synthase EC 2.3.3.10 is an enzyme which catalyzes the reaction in which acetyl-CoA condenses with acetoacetyl-CoA to form 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA). This reaction comprises the second step in the mevalonate-dependent isoprenoid biosynthesis pathway. HMG-CoA is an intermediate in both cholesterol synthesis and ketogenesis. This reaction is overactivated in patients with diabetes mellitus type 1 if left untreated, due to prolonged insulin deficiency and the exhaustion of substrates for gluconeogenesis and the TCA cycle, notably oxaloacetate. This results in shunting of excess acetyl-CoA into the ketone synthesis pathway via HMG-CoA, leading to the development of diabetic ketoacidosis.

The biosynthesis of phenylpropanoids involves a number of enzymes.

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Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase (EC 4.2.1.134, PHS1 (gene), PAS2 (gene)) is an enzyme with systematic name very-long-chain (3R)-3-hydroxyacyl-CoA hydro-lyase. This enzyme catalyses the following chemical reaction

<span class="mw-page-title-main">Dihydrodipicolinate synthase</span> Class of enzymes

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References


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