Vinod Scaria

Last updated

Dr Vinod Scaria
Born (1981-03-09) 9 March 1981 (age 42)
Mbinga, Tanzania
NationalityIndian
CitizenshipIndian
Alma mater Calicut Medical College
University of Pune
Awards
  • CSIR Young Scientist Award (2012)
  • FRSB (2017)
Scientific career
Fields Bioinformatics, Computational Biology
Institutions Indraprastha Institute of Information Technology Delhi,
Institute of Genomics and Integrative Biology,
Academy of Scientific and Innovative Research
Doctoral advisor Samir K. Brahmachari
Website vinodscaria.rnabiology.org

Dr Vinod Scaria FRSB, FRSPH (born 9 March 1981) is an Indian biologist, medical researcher pioneering in Precision Medicine and Clinical Genomics in India. He is best known for sequencing the first Indian genome. [1] [2] [3] He was also instrumental in the sequencing of The first Sri Lankan Genome, analysis of the first Malaysian Genome [4] sequencing and analysis of the Wild-type strain of Zebrafish [5] and the IndiGen programme on Genomics for Public Health in India. [6] [7] [8]

Contents

He is presently a senior consultant to Vishwanath Cancer Care Foundation, an Adjunct Professor at the IIT Kanpur. [9] He was previously a senior scientist at CSIR Institute of Genomics and Integrative Biology and an adjunct faculty at Indraprastha Institute of Information Technology, Delhi. [10]

He along with his colleague and collaborator Sridhar Sivasuubu are widely regarded as the pioneers in the area of clinical genomics in India. They are also the co-founders of the Genomics for Understanding Rare Diseases India Alliance Network (GUaRDIAN) a large clinical network working in the area of Rare Disease Genomics in India. They were also instrumental in setting up a comprehensive fellowship programme in genomics for clinicians [11]

His research has also contributed to a number of commercially viable technologies for healthcare and public health applications. [12] This includes one of the methods for fast and accurate diagnosis and screening of mitochondrial genetic diseases. [13]

Early life

Scaria was born in Tanzania in 1981. He did his schooling in Silver Hills Public School, Kozhikode, India. He studied for pre-degree course in St. Joseph's College, Devagiri and completed his undergraduate studies in medicine and surgery from Calicut Medical College with gold medals in Biochemistry and Physiology. He worked as a consultant for information technology at the Pain and Palliative Care society in Kozhikode. Later, he joined the CSIR Institute of Genomics and Integrative Biology, New Delhi, where he started his career as a researcher. [14]

Research

Scaria started his research career at Calicut Medical College in the area of medical ethics and health information on Internet. After joining the CSIR Institute of Genomics and Integrative Biology in 2005, he switched to computational biology and genome informatics. His notable researches include the identification of human micro-RNA which can target HIV virus. In 2009 he and his colleagues at the Institute of Genomics and Integrative Biology announced the sequencing of the wild-type strain of zebrafish [15] and the sequencing of the first Human Genome from India. He also pioneered the use of social web for genome annotation, through mapping of TB genome. [16] Scaria and colleagues also discovered and designed enzyme silencers for mRNA, dubbed antagomirzymes. His group also pioneered the use of social web, cloud computing and students for solving complex drug discovery problems for Neglected Diseases. [17] Dr Scaria has also been involved in popularising personal genomics through meragenome.com [18] and OpenPGx. [19]

His research took a shift to Clinical Genomics in 2009 starting with the sequencing of the first Indian Genome in 2009. [20] Over years he with colleague, Sridhar Sivasubbu created a large research network in area of Clinical Genomics with focus on rare genetic diseases and pharmacogenomics. The focus has been to use genomic tools to understand the molecular basis of genetic diseases in India and use this knowledgebase to develop affordable and accessible genetic tests. [21] This initiative helped uncover the genetic basis of many inherited diseases in India [22]

His research has also led to knowhow which has been successfully licensed to a number of commercial diagnostic entities and available to clinicians across India. [23]

He has published over 150 papers in international journals. [24] He is also the editorial board member of many reputed International Journals including PLOS ONE, PeerJ , International Journal of Rheumatic Diseases and Journal of Translational Medicine. He was a member of senate of the Academy of Scientific and Innovative Research (AcSIR).

Accolades

He was conferred the CSIR Young Scientist Award for biological sciences for developing computational tools to analyse genomic data, by the Prime Minister of India in September 2012. [25] [26] [27]

He is a Kavli Frontiers of Science Fellow of the US National Academy of Sciences [28] and an elected Fellow of the Royal Society of Biology. [29] and elected Fellow of the Royal Society of Public Health [30]

Precision Medicine and Pharmacogenomics in India

He specialises in genome-scale data for Precision Medicine with reference to Pharmacogenetics. He was one of the pioneers to be able to systematically analyse personal genome data to derive pharmacogenetic maps. [4] His research into population-specific genome scale data has provided one of the initial pharmacoepigenetic maps for Malaysia [31] and Qatar. [32] He research also contributed to the first population-scale pharmacogenomic maps for India. [33] [34]

Scaria has been pioneering the application of genomics to diagnose and solve rare genetic diseases in India, including discovering novel variants. [35] He, with his colleague Sridhar Sivasubbu co-founded a national network (GUaRDIAN) [36] of clinicians and researchers working on rare disease genomics. He also co-authored a handbook on exome sequencing and analysis for clinicians. [37] The GUaRDIAN consortium includes over 250 clinicians and researchers from over 70 medical and research centers making it one of the largest clinical genomics research networks in India working in the area of Rare Genetic Diseases. [38] The research network has been quite successful in understanding variants associated with rare genetic diseases and be able to prevent them. [39]

His lab has also contributed to one of the most comprehensive evidence resources for mutation specific therapies in cancer [40]

Genomics and other Omics Technologies to enable Medical Decisions (GOMED) Scaria has been involved in creating a unique programme along with his colleague Dr Mohammed Faruq which enable clinicians from across the country to tap into the rich expertise of CSIR Institute of Genomics and Integrative Biology in the area of genomics to enable fast and effective diagnosis of genetic diseases. [41] This programme today has been widely utilized by hospitals across the country. [42]

The IndiGen programme [43] on population Genomics for public health was initiated in 2019 with an attempt to start understanding the genetic diversity of the country by sequencing over a thousand Indian individuals. [44] "The outcomes of IndiGen will have applications in a number of areas including faster and efficient diagnosis of rare genetic diseases", said Union Science Minister, Harsh Vardhan, at the press conference announcing the programme. [45] The programme has accelerated the commercial adaptation and application of genomics in India by working closely with various industrial partners. [12] The summary data from the programme is available for researchers and clinicians. [46]

Genomics of Arab and Middle Eastern Populations

Scaria has been pioneering the analysis of genomic data from Arab, Middle Eastern populations. His lab contributed to understanding the genetic landscape of Pharmacogenetics in Qatar. [47] [48] He also pioneered the use of whole genome data to understand the genetic epidemiology of prevalent diseases in the region, including Familial Mediterranean Fever. [49]

His lab also created one of the largest and comprehensive allele frequency resource for Arab populations. [50] This database al mena [51] (alleles for Middle East and North Africa) provides information on over 26 million variants indexing a number of whole genome and exome datasets from the region. He is also pioneering the creation of a comprehensive resource for disease variants in the Arab population, in collaboration with multiple researchers from the region. [52] He also pioneered the application of genomics in transfusion medicine with the alnasab database, a comprehensive resource for blood group variants in Arabs [53]

Open Research, Data and Resources for tracking and understanding Epidemics

The COVID-19 Open Research, Data and Resources is an initiative to make relevant Data, Research and Resources [54] at the Vinod Scaria Lab at the CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB) in an open format to ensure that they are widely accessible as well as relevant. The initiative provides ready access to genomic, [55] [56] [57] epidemiological data-sets [58] and protocols [59] pertaining to the COVID-19 epidemic in India. The research also contributed to the understanding of a new clade (I/A3i) of SARS-CoV-2 genomes from India. [60] [61] His group also contributed to uncovering the first reports of COVID-19 reinfection in India [62] and a comprehensive resource on reinfections. [63] He also pioneered research into the genomic characterization of COVID-19 vaccine breakthrough infections. [64] [65] His research also reviewed the risk of monogenic diseases in COVID-19. [66] He has also been instrumental in creating a comprehensive genomic surveillance programme for SARS-CoV-2 in the state of Kerala [67] [68] which has been able to provide early insights into variants and influencing policy. [69] His group also pioneered the EpidemicWatch network [70] and the first participatory digital infection surveillance system Infectiradar [71] in India.

The recent Zika virus outbreak [72] in Kerala has seen Open research approaches to track and understand the epidemic [73] as part of a framework for Citizen science

Related Research Articles

<span class="mw-page-title-main">Government Medical College, Kozhikode</span> Medical school in Kerala, India

Government Medical College, Kozhikode, also known as Calicut Medical College (CMC), is a school of medicine in Kozhikode in the Indian state of Kerala. The college was established in 1957 as the second medical college in Kerala by DR.A.AR.MENON MBBS, FRCH, Minister for Health, EMS ministry. With over 3025 beds, it is currently the largest hospital in India and tenth largest in the world. It is also one of India's largest hospitals by area, covering more than 270 acres of land in the outskirts of Kozhikode city. Formerly affiliated to the University of Calicut, the college is now attached to the Kerala University of Health Sciences (KUHS). Calicut Medical College is the most preferred medical college of Kerala during both All India as well as state counsellings for MBBS admission.

<span class="mw-page-title-main">Marco Marra</span> Canadian geneticist

Marco A. Marra is a Distinguished Scientist and Director of Canada's Michael Smith Genome Sciences Centre at the BC Cancer Research Centre and Professor of Medical Genetics at the University of British Columbia (UBC). He also serves as UBC Canada Research Chair in Genome Science for the Canadian Institutes of Health Research and is an inductee in the Canadian Medical Hall of Fame. Marra has been instrumental in bringing genome science to Canada by demonstrating the pivotal role that genomics can play in human health and disease research.

Personal genomics or consumer genetics is the branch of genomics concerned with the sequencing, analysis and interpretation of the genome of an individual. The genotyping stage employs different techniques, including single-nucleotide polymorphism (SNP) analysis chips, or partial or full genome sequencing. Once the genotypes are known, the individual's variations can be compared with the published literature to determine likelihood of trait expression, ancestry inference and disease risk.

<span class="mw-page-title-main">Whole genome sequencing</span> Determining nearly the entirety of the DNA sequence of an organisms genome at a single time

Whole genome sequencing (WGS), also known as full genome sequencing, complete genome sequencing, or entire genome sequencing, is the process of determining the entirety, or nearly the entirety, of the DNA sequence of an organism's genome at a single time. This entails sequencing all of an organism's chromosomal DNA as well as DNA contained in the mitochondria and, for plants, in the chloroplast.

The exome is composed of all of the exons within the genome, the sequences which, when transcribed, remain within the mature RNA after introns are removed by RNA splicing. This includes untranslated regions of messenger RNA (mRNA), and coding regions. Exome sequencing has proven to be an efficient method of determining the genetic basis of more than two dozen Mendelian or single gene disorders.

<span class="mw-page-title-main">Institute of Genomics and Integrative Biology</span> Indian scientific research institute

CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB) is a scientific research institute devoted primarily to biological research. It is a part of Council of Scientific and Industrial Research (CSIR), India.

Samir Kumar Brahmachari is an Indian biophysicist and Former Director General of the Council of Scientific & Industrial Research (CSIR) and Former Secretary, Department of Scientific and Industrial Research (DSIR), Government of India. He is the Founder Director of Institute of Genomics and Integrative Biology (IGIB), New Delhi and the Chief Mentor of Open Source for Drug Discovery (OSDD) Project. He is the recipient of J.C Bose Fellowship Award, DST (2012). In addition, he is one of the featured researchers in the India Cancer Research Database developed by Institute of Bioinformatics (IOB), Bangalore with support from the Department of Biotechnology, Government of India.

<span class="mw-page-title-main">Exome sequencing</span> Sequencing of all the exons of a genome

Exome sequencing, also known as whole exome sequencing (WES), is a genomic technique for sequencing all of the protein-coding regions of genes in a genome. It consists of two steps: the first step is to select only the subset of DNA that encodes proteins. These regions are known as exons—humans have about 180,000 exons, constituting about 1% of the human genome, or approximately 30 million base pairs. The second step is to sequence the exonic DNA using any high-throughput DNA sequencing technology.

<span class="mw-page-title-main">Andrew Kasarskis</span> American biologist

Andrew Kasarskis is an American biologist. He is the Chief Data Officer (CDO) at Sema4. He was previously CDO and an Executive Vice President (EVP) at the Mount Sinai Health System in New York City and, before that, vice chair of the Department of Genetics and Genomic Sciences and Co-director of the Icahn Institute for Genomics and Multiscale Biology at the Icahn School of Medicine at Mount Sinai. Kasarskis is known for taking a network-based approach to biology and for directing the first medical school class offering students the opportunity to fully sequence and analyze their own genomes.

<span class="mw-page-title-main">Genotype-first approach</span>

The genotype-first approach is a type of strategy used in genetic epidemiological studies to associate specific genotypes to apparent clinical phenotypes of a complex disease or trait. As opposed to “phenotype-first”, the traditional strategy that has been guiding genome-wide association studies (GWAS) so far, this approach characterizes individuals first by a statistically common genotype based on molecular tests prior to clinical phenotypic classification. This method of grouping leads to patient evaluations based on a shared genetic etiology for the observed phenotypes, regardless of their suspected diagnosis. Thus, this approach can prevent initial phenotypic bias and allow for identification of genes that pose a significant contribution to the disease etiology.

The Qatar Genome Programme aims to sequence the genomes of 350,000 inhabitants of Qatar. Supported by the Sidra Medical and Research Center, the program is managed by Qatar Genome Committee and wants to eventually offer personalized healthcare in Qatar to its population with advances in genomics. The Qatar Genome Programme published its first genome-wide association study with 45 clinically relevant traits in 2021

Elective genetic and genomic testing are DNA tests performed for an individual who does not have an indication for testing. An elective genetic test analyzes selected sites in the human genome while an elective genomic test analyzes the entire human genome. Some elective genetic and genomic tests require a physician to order the test to ensure that individuals understand the risks and benefits of testing as well as the results. Other DNA-based tests, such as a genealogical DNA test do not require a physician's order. Elective testing is generally not paid for by health insurance companies. With the advent of personalized medicine, also called precision medicine, an increasing number of individuals are undertaking elective genetic and genomic testing.

Shantanu Sengupta is an Indian cell biologist and a professor at the Institute of Genomics and Integrative Biology (IGIB) of the Council of Scientific and Industrial Research. At IGIB, he coordinates the activities of the National Facility for Biochemical and Genomic Resources (NFBGR) and the Proteomics and Structural Biology Unit of the institute. He is a member of the executive council of the Proteomic Society, India and is known for his studies of cardiovascular diseases from a genetic perspective as well as of Homocysteine with regard to its toxicity and its role in epigenetic modifications. His studies have been documented by way of a number of articles and ResearchGate, an online repository of scientific articles has listed 149 of them. The Department of Biotechnology of the Government of India awarded him the National Bioscience Award for Career Development, one of the highest Indian science awards, for his contributions to biosciences, in 2011.

Debasis Dash is an Indian computational biologist and chief scientist at the Institute of Genomics and Integrative Biology (IGIB). Known for his research on proteomics and Big Data and Artificial Intelligence studies, his studies have been documented by way of a number of articles and ResearchGate, an online repository of scientific articles has listed 120 of them. The Department of Biotechnology of the Government of India awarded him the National Bioscience Award for Career Development, one of the highest Indian science awards, for his contributions to biosciences, in 2014. He is appointed as the director of Institute of Life Sciences, Bhubaneswar on 18 May 2023.

Beena Ramakrishnan Pillai is an Indian microbiologist, geneticist, and a scientist at the Institute of Genomics and Integrative Biology. She is known for her studies on gene regulation influenced by small RNA and histone variants and is a recipient of the Young Scientist Award of the Council of Scientific and Industrial Research and the Young Scientist Medal of the INSA. The Department of Biotechnology of the Government of India awarded her the National Bioscience Award for Career Development, one of the highest Indian science awards, for her contributions to biosciences, in 2017–18.

Human Heredity and Health in Africa, or H3Africa, is an initiative to study the genomics and medical genetics of African people. Its goals are to build the continent's research infrastructure, train researchers and clinicians, and to study questions of scientific and medical interest to Africans. The H3Africa Consortium was formally launched in 2012 in Addis Ababa and has grown to include research projects across 32 countries, a pan-contintental bioinformatics network, and the first whole genome sequencing of many African ethnolinguistic groups.

<span class="mw-page-title-main">COVID-19 Genomics UK Consortium</span> British genomics research consortium

The COVID-19 Genomics UK Consortium (COG-UK) was a group of public health agencies and academic institutions in the United Kingdom created in April 2020 to collect, sequence and analyse genomes of SARS-CoV-2 as part of COVID-19 pandemic response. The consortium comprised the UK's four public health agencies, National Health Service organisations, academic partners and the Wellcome Sanger Institute. The consortium was known for first identifying the SARS-CoV-2 Alpha variant in November 2020. As of January 2021, 45% of all SARS-CoV-2 sequences uploaded to the GISAID sequencing database originated from COG-UK.

INSACOG is the forum set up under the Ministry of Health and Family Welfare by the Government of India on 30 December 2020, to study and monitor genome sequencing and virus variation of circulating strains of COVID-19 in India. Initially it was tasked to study the virus variant Lineage B.1.1.7 earlier found in United Kingdom in December 2020.

<span class="mw-page-title-main">Deborah Nickerson</span> American human genomics researcher (1954–2021)

Deborah Ann "Debbie" Nickerson was an American human genomics researcher. She was professor of genome sciences at the University of Washington. Nickerson founded and directed of one of the five clinical sites of the Gregor Consortium and was a major contributor to many genomics projects, including the Human Genome Project and the International HapMap Project.

Personalized genomics is the human genetics-derived study of analyzing and interpreting individualized genetic information by genome sequencing to identify genetic variations compared to the library of known sequences. International genetics communities have spared no effort from the past and have gradually cooperated to prosecute research projects to determine DNA sequences of the human genome using DNA sequencing techniques. The methods that are the most commonly used are whole exome sequencing and whole genome sequencing. Both approaches are used to identify genetic variations. Genome sequencing became more cost-effective over time, and made it applicable in the medical field, allowing scientists to understand which genes are attributed to specific diseases.

References

  1. ↑ Manoj CG (10 December 2009). "After human genome sequence, the scientist duo look ahead". The Indian Express. Retrieved 10 February 2013.
  2. ↑ Prasanth GN (10 December 2009). "Genome sequencing can be applied in clinical setting". The Times of India . Archived from the original on 28 September 2013. Retrieved 10 February 2013.
  3. ↑ Jingjing H (9 December 2009). "Scientists decode human genome for the first time in India". China News. Archived from the original on 13 December 2009. Retrieved 10 February 2013.
  4. 1 2 Salleh MZ, Teh LK, Lee LS, Ismet RI, Patowary A, Joshi K, et al. (2013). "Systematic pharmacogenomics analysis of a Malay whole genome: proof of concept for personalized medicine". PLOS ONE. 8 (8): e71554. Bibcode:2013PLoSO...871554S. doi: 10.1371/journal.pone.0071554 . PMC   3751891 . PMID   24009664.
  5. ↑ Patowary A, Purkanti R, Singh M, Chauhan R, Singh AR, Swarnkar M, et al. (March 2013). "A sequence-based variation map of zebrafish". Zebrafish. 10 (1): 15–20. doi:10.1089/zeb.2012.0848. PMC   3629779 . PMID   23590399.
  6. ↑ "The Gene Business- Business News". businesstoday.in. 18 February 2020. Retrieved 22 June 2020.
  7. ↑ Koshy, Jacob (25 October 2019). "CSIR offers free mapping of Indian genomes". The Hindu. ISSN   0971-751X . Retrieved 22 June 2020.
  8. ↑ "Genomics for Public Health". sites.google.com. Retrieved 22 June 2020.
  9. ↑ "Adjunct Faculty". www.iitk.ac.in. Retrieved 11 November 2023.
  10. ↑ "Visiting and Adjunct Faculty at IIIT-D".
  11. ↑ "Genomics training for clinicians - CSIR-IGIB Sanofi Genzyme fellowship: From labs to patients". Genomics training for clinicians - CSIR-IGIB Sanofi Genzyme fellowship. Retrieved 14 March 2020.
  12. 1 2 "The Gene Business- Business News". businesstoday.in. 18 February 2020. Retrieved 14 March 2020.
  13. ↑ Prasad, R. (10 July 2016). "Screening for rare genetic disorders at a point-of-click". The Hindu. ISSN   0971-751X . Retrieved 14 March 2020.
  14. ↑ "Vinod Scaria's profile". Institute of Genomics and Integrative Biology. Retrieved 10 February 2013.
  15. ↑ "Genome of Zebrafish Wild-type Strain (ASWT)". IGIB.in. Retrieved 17 April 2013.
  16. ↑ "Detailed map of TB genome to help treatment". The Hindustan Times. 12 April 2010. Archived from the original on 11 April 2013. Retrieved 10 February 2013.
  17. ↑ "Crowd Computing for Cheminformatics". RNA Biology. Archived from the original on 12 January 2013. Retrieved 17 February 2013.
  18. ↑ "meragenome.com : Personal Genomics for All" . Retrieved 10 April 2013.
  19. ↑ "OpenPGx" . Retrieved 10 April 2013.
  20. ↑ "After human genome sequence, scientist duo looks ahead - Indian Express". archive.indianexpress.com. Retrieved 14 February 2020.
  21. ↑ Garari, Kaniza (26 December 2018). "CSIR stands tall with 10 innovations in 2018". Deccan Chronicle. Retrieved 14 February 2020.
  22. ↑ Koshy, Jacob (15 April 2017). "Interpretation of a malady: how scientists zeroed in on one family's rare and crippling disease". The Hindu. ISSN   0971-751X . Retrieved 14 February 2020.
  23. ↑ Prasad, R. (10 July 2016). "Screening for rare genetic disorders at a point-of-click". The Hindu. ISSN   0971-751X . Retrieved 14 February 2020.
  24. ↑ "Publications of Vinod Scaria". RNA Biology. Retrieved 10 February 2013.
  25. ↑ "Young Scientist Awards" (PDF). CSIR, India. Retrieved 10 February 2013.
  26. ↑ "PM gives away awards to scientists". MBCTV. 26 September 2012. Retrieved 10 February 2013.
  27. ↑ "PM gives Swaroop Bhatnagar award to 11 scientists". Outlook.com. 26 September 2012. Retrieved 10 February 2013.
  28. ↑ "Vinod Scaria".
  29. ↑ "Vinod Scaria - Vinod Scaria MBBS, PHD".
  30. ↑ RSPH. "Royal Society for Public Health UK". www.rsph.org.uk. Retrieved 17 January 2022.
  31. ↑ Prasad R (12 June 2016). "Why Indians, SE Asian Malays respond differently to some drugs". The Hindu. Retrieved 10 October 2016.
  32. ↑ Sarant L (2016). "Qatar exome study: An advancement in precision medicine". Nature Middle East. doi:10.1038/nmiddleeast.2016.137.
  33. ↑ Sahana, S.; Bhoyar, Rahul C.; Sivadas, Ambily; Jain, Abhinav; Imran, Mohamed; Rophina, Mercy; Senthivel, Vigneshwar; Kumar Diwakar, Mohit; Sharma, Disha; Mishra, Anushree; Sivasubbu, Sridhar (April 2022). "Pharmacogenomic landscape of Indian population using whole genomes". Clinical and Translational Science. 15 (4): 866–877. doi:10.1111/cts.13153. ISSN   1752-8054. PMC   9010271 . PMID   35338580.
  34. ↑ Sahana, S; Sivadas, Ambily; Mangla, Mohit; Jain, Abhinav; Bhoyar, Rahul C; Pandhare, Kavita; Mishra, Anushree; Sharma, Disha; Imran, Mohamed; Senthivel, Vigneshwar; Divakar, Mohit Kumar (1 July 2021). "Pharmacogenomic landscape of COVID-19 therapies from Indian population genomes". Pharmacogenomics. 22 (10): 603–618. doi:10.2217/pgs-2021-0028. ISSN   1462-2416. PMC   8216321 . PMID   34142560.
  35. ↑ Vellarikkal SK, Patowary A, Singh M, Kumari R, Faruq M, Master DC, et al. (2014). "Exome sequencing reveals a novel mutation, p.L325H, in the KRT5 gene associated with autosomal dominant Epidermolysis Bullosa Simplex Koebner type in a large family from western India". Human Genome Variation. 1: 14007. doi:10.1038/hgv.2014.7. PMC   4785511 . PMID   27081501.
  36. ↑ "Genomics for Understanding Rare Diseases India Alliance Network" . Retrieved 25 December 2014.
  37. ↑ Scaria V, Sivasubbu S (11 February 2015). Exome Sequencing, Analysis and Interpretation : Handbook for Clinicians. India: Research in Genomics. p. 126. Retrieved 5 April 2015.
  38. ↑ Sivasubbu S, Scaria V (September 2019). "Genomics of rare genetic diseases-experiences from India". Human Genomics. 14 (1): 52. doi: 10.1186/s40246-019-0215-5 . PMC   6760067 . PMID   31554517.
  39. ↑ Isalkar U (6 October 2016). "Research on genes rules out ailment in youngest sibling". The Times of India. TNN. Retrieved 10 October 2016.
  40. ↑ Mittal, Gauri; R I, Anu; Vatsyayan, Aastha; Pandhare, Kavita; Scaria, Vinod (1 January 2021). "MUSTARD—a comprehensive resource of mutation-specific therapies in cancer". Database. 2021: baab042. doi:10.1093/database/baab042. ISSN   1758-0463. PMC   8312254 . PMID   34309639.
  41. ↑ "Genomics and other omics technologies to enable Medical Decisions".
  42. ↑ "Referral statistics of GOMED".
  43. ↑ "Genomics for Public Health". sites.google.com. Retrieved 13 November 2019.
  44. ↑ Koshy, Jacob (19 April 2019). "Genome sequencing to map population diversity". The Hindu. ISSN   0971-751X . Retrieved 13 November 2019.
  45. ↑ Koshy, Jacob (25 October 2019). "CSIR offers free mapping of Indian genomes". The Hindu. ISSN   0971-751X . Retrieved 13 November 2019.
  46. ↑ "IndiGenomes Resource of Population Genomes from India". clingen.igib.res.in. Retrieved 14 March 2020.
  47. ↑ Sivadas A, Sharma P, Scaria V (November 2016). "Landscape of warfarin and clopidogrel pharmacogenetic variants in Qatari population from whole exome datasets". Pharmacogenomics. 17 (17): 1891–1901. doi:10.2217/pgs-2016-0130. PMID   27767380.
  48. ↑ Sivadas A, Scaria V (July 2018). "Pharmacogenomic survey of Qatari populations using whole-genome and exome sequences". The Pharmacogenomics Journal. 18 (4): 590–600. doi:10.1038/s41397-018-0022-8. PMID   29720721. S2CID   24137943.
  49. ↑ Koshy R, Sivadas A, Scaria V (January 2018). "Genetic epidemiology of familial Mediterranean fever through integrative analysis of whole genome and exome sequences from Middle East and North Africa". Clinical Genetics. 93 (1): 92–102. doi:10.1111/cge.13070. PMID   28597968. S2CID   27609668.
  50. ↑ Koshy R, Ranawat A, Scaria V (October 2017). "al mena: a comprehensive resource of human genetic variants integrating genomes and exomes from Arab, Middle Eastern and North African populations". Journal of Human Genetics. 62 (10): 889–894. doi:10.1038/jhg.2017.67. PMID   28638141. S2CID   36515834.
  51. ↑ "al mena". clingen.igib.res.in.
  52. ↑ "Comprehensive resource of genetic variants associated with diseases in Arabs - Vinod Scaria MBBS, PhD". vinodscaria.rnabiology.org.
  53. ↑ "GME". clingen.igib.res.in. Retrieved 17 January 2022.
  54. ↑ "COVID-19 Open - Vinod Scaria MBBS, PhD". vinodscaria.rnabiology.org. Retrieved 16 April 2020.
  55. ↑ "India to have own genome data bank to decode COVID-19 virus". The New Indian Express. Retrieved 19 June 2020.
  56. ↑ "INDICOV". clingen.igib.res.in. Retrieved 19 June 2020.
  57. ↑ "COVID-19 Genomepedia , a comprehensive searchable resource of SARS-nCoV-2 genomes | CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB) Delhi, India". COVID-19 Genomepedia , a comprehensive searchable resource of SARS-nCoV-2 genomes | CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB) Delhi, India. Retrieved 16 April 2020.
  58. ↑ "Genomes & Genetic Epidemiology of SARS-nCoV-2 - Vinod Scaria MBBS, PhD". vinodscaria.rnabiology.org. Retrieved 16 April 2020.
  59. ↑ Poojary, Mukta; Shantaraman, Anantharaman; Jolly, Bani; Scaria, Vinod (2019). "Computational Protocol for Assembly and Analysis of SARS-nCoV-2 Genomes". Research Reports. 4.
  60. ↑ Banu, Sofia; Jolly, Bani; Mukherjee, Payel; Singh, Priya; Khan, Shagufta; Zaveri, Lamuk; Shambhavi, Sakshi; Gaur, Namami; Mishra, Rakesh K.; Scaria, Vinod; Sowpati, Divya Tej (31 May 2020). "A distinct phylogenetic cluster of Indian SARS-CoV-2 isolates". bioRxiv: 2020.05.31.126136. doi: 10.1101/2020.05.31.126136 . S2CID   219535426.
  61. ↑ Banu, Sofia; Jolly, Bani; Mukherjee, Payel; Singh, Priya; Khan, Shagufta; Zaveri, Lamuk; Shambhavi, Sakshi; Gaur, Namami; Reddy, Shashikala; Kaveri, K.; Srinivasan, Sivasubramanian (2020). "A distinct phylogenetic cluster of Indian SARS-CoV-2 isolates". Open Forum Infectious Diseases. 7 (11): ofaa434. doi: 10.1093/ofid/ofaa434 . PMC   7543508 . PMID   33200080. S2CID   222209242.
  62. ↑ Gupta, Vivek; Bhoyar, Rahul C.; Jain, Abhinav; Srivastava, Saurabh; Upadhayay, Rashmi; Imran, Mohamed; Jolly, Bani; Divakar, Mohit Kumar; Sharma, Disha; Sehgal, Paras; Ranjan, Gyan (2020). "Asymptomatic reinfection in two healthcare workers from India with genetically distinct SARS-CoV-2". Clinical Infectious Diseases. 73 (9): e2823–e2825. doi:10.1093/cid/ciaa1451. PMC   7543380 . PMID   32964927.
  63. ↑ "COVID-19 REINFECTIONS". sites.google.com. Retrieved 30 September 2020.
  64. ↑ Singh, Urvashi B.; Rophina, Mercy; Chaudhry, Rama; Senthivel, Vigneshwar; Bala, Kiran; Bhoyar, Rahul C.; Jolly, Bani; Jamshed, Nayer; Imran, Mohamed; Gupta, Ritu; Aggarwal, Praveen; Divakar, Mohit Kumar; Sinha, Subrata; v.r, Arvinden; Bajaj, Anjali; Shamnath, Afra; Jain, Abhinav; Group, Covid Cbnaat Core; Scaria, Vinod; Sivasubbu, Sridhar; Guleria, Randeep (3 June 2021). "Variants of Concern responsible for SARS-CoV-2 vaccine breakthrough infections from India". osf.io. doi:10.31219/osf.io/fgd4x. S2CID   241703030 . Retrieved 1 April 2023.
  65. ↑ J, Beena Philomina; Jolly, Bani; John, Neethu; Bhoyar, Rahul C.; Majeed, Nisha; Senthivel, Vigneshwar; P, Fairoz C.; Rophina, Mercy; Vasudevan, Bindhu; Imran, Mohamed; Viswanathan, Prasanth (24 May 2021). "Genomic survey of SARS-CoV-2 vaccine breakthrough infections in healthcare workers from Kerala, India". Journal of Infection. 83 (2): 237–279. doi:10.1016/j.jinf.2021.05.018. ISSN   0163-4453. PMC   8143909 . PMID   34044037.
  66. ↑ Cotsapas, Chris; Saarela, Janna; Farmer, Jocelyn R.; Scaria, Vinod; Abraham, Roshini S. (1 June 2021). "Do monogenic inborn errors of immunity cause susceptibility to severe COVID-19?". The Journal of Clinical Investigation. 131 (14). doi: 10.1172/JCI149459 . ISSN   0021-9738. PMC   8279660 . PMID   34061775.
  67. ↑ "GENESCoV2 Kerala". genescov2.genomes.in. Retrieved 3 June 2021.
  68. ↑ Bhagat, Shalini Venugopal (23 May 2021). "As India Stumbles, One State Charts Its Own Covid Course". The New York Times. ISSN   0362-4331 . Retrieved 3 June 2021.
  69. ↑ Milan Sharma (24 May 2021). "B.1.617.2 becoming dominant variant in India, finds genome sequencing". India Today. Retrieved 3 June 2021.
  70. ↑ "KAISER - EpidemicWatch". kaiser.genomes.in. Retrieved 18 May 2022.
  71. ↑ "KAISER - Infectiradar". kaiser.genomes.in. Retrieved 18 May 2022.
  72. ↑ "Zika virus: India's Kerala state on alert after 14 cases reported". BBC News. 9 July 2021. Retrieved 14 July 2021.
  73. ↑ "KAISER - Zika Open Research". kaiser.genomes.in. Retrieved 14 July 2021.
This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.