Wound licking

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A gorilla licking a wound Gorilla licking wound.jpg
A gorilla licking a wound

Wound licking is an instinctive response in humans and many other animals to cover an injury or second degree burn [1] with saliva. Dogs, cats, small rodents, horses, and primates all lick wounds. [2] Saliva contains tissue factor which promotes the blood clotting mechanism. The enzyme lysozyme is found in many tissues and is known to attack the cell walls of many gram-positive bacteria, aiding in defense against infection. Tears are also beneficial to wounds due to the lysozyme enzyme. However, there are also infection risks due to bacteria in the mouth.

Contents

Mechanism

A dog licking a wounded paw Dog licking wound.jpg
A dog licking a wounded paw

Oral mucosa heals faster than skin, [3] suggesting that saliva may have properties that aid wound healing. Saliva contains cell-derived tissue factor, and many compounds that are antibacterial or promote healing. Salivary tissue factor, associated with microvesicles shed from cells in the mouth, promotes wound healing through the extrinsic blood coagulation cascade. [4] [5] [6] The enzymes lysozyme and peroxidase, [7] defensins, [8] cystatins and an antibody, IgA, [9] are all antibacterial. Thrombospondin and some other components are antiviral. [10] [11] A protease inhibitor, secretory leukocyte protease inhibitor, is present in saliva and is both antibacterial and antiviral, and a promoter of wound healing. [12] [13] Nitrates that are naturally found in saliva break down into nitric oxide on contact with skin, which will inhibit bacterial growth. [14] Saliva contains growth factors [15] such as epidermal growth factor, [16] VEGF, [17] TGF-β1, [18] leptin, [19] [20] IGF-I, [21] [22] lysophosphatidic acid, [23] [24] hyaluronan [25] and NGF, [26] [27] [28] which all promote healing, although levels of EGF and NGF in humans are much lower than those in rats. In humans, histatins may play a larger role. [29] [30] As well as being growth factors, IGF-I and TGF-α induce antimicrobial peptides. [31] Saliva also contains an analgesic, opiorphin. [32] Licking will also tend to debride the wound and remove gross contamination from the affected area. In a recent study, scientists have confirmed through several experiments that the protein responsible for healing properties in human saliva is, in fact, histatin. Scientists are now looking for ways to make use of this information in ways that can lead to chronic wounds, burns, and injuries being healed by saliva. [33]

In animals

A cat with an Elizabethan collar Cat with Elizabethan collar.jpg
A cat with an Elizabethan collar
Lick granuloma from excessive licking Canine lick granuloma.jpg
Lick granuloma from excessive licking

It has been long observed that the licking of their wounds by dogs might be beneficial. Indeed, a dog's saliva is bactericidal against the bacteria Escherichia coli and Streptococcus canis , although not against coagulase-positive Staphylococcus or Pseudomonas aeruginosa . [34] Wound licking is also important in other animals. Removal of the salivary glands of mice [35] and rats slows wound healing, and communal licking of wounds among rodents accelerates wound healing. [36] [37] Communal licking is common in several primate species. In macaques, hair surrounding a wound and any dirt is removed, and the wound is licked, healing without infection. [38]

Risks

Wound licking is beneficial but too much licking can be harmful. An Elizabethan collar may be used on pet animals to prevent them from biting an injury or excessively licking it, which can cause a lick granuloma. These lesions are often infected by pathogenic bacteria such as Staphylococcus intermedius. [39] Horses that lick wounds may become infected by a stomach parasite, Habronema , a type of nematode worm. The rabies virus may be transmitted between animals, such as the kudu antelopes by wound licking of wounds with residual infectious saliva. [40]

In humans

Religion and legend

There are many legends involving healing wounds by licking them or applying saliva. Saint Magdalena de Pazzi is said to have cured a nun of sores and scabs in 1589 by licking her limbs. [41] The Roman Emperor Vespasian is said to have performed a healing of a blind man using his saliva. [42] Pliny the Elder in his Natural History reported that a fasting woman's saliva is an effective cure for bloodshot eyes. [43]

In the Hebrew Bible saliva is associated with uncleanliness. However, in the Gospels, there are three different incidents in which Jesus uses saliva to cure (Mark 7:33, Mark 8:23, John 9:6). Köstenberger suggests "by using saliva to cure a man, Jesus claims to possess unusual spiritual authority." [44]

Risks

There are potential health hazards in wound licking due to infection risk, especially in immunocompromised patients. Human saliva contains a wide variety of bacteria that are harmless in the mouth, but that may cause significant infection if introduced into a wound. A notable case was a diabetic man who licked his bleeding thumb following a minor bicycle accident, and subsequently had to have the thumb amputated after it became infected with Eikenella corrodens from his saliva. [45]

Licking of people's wounds by animals

History and legend

Dog saliva has been said by many cultures to have curative powers in people. [46] [47] "Langue de chien, langue de médecin" is a French saying meaning "A dog's tongue is a doctor's tongue", and a Latin quote that "Lingua canis dum lingit vulnus curat" or "A dog's saliva can heal your wound" appears in a thirteenth-century manuscript. [48] In Ancient Greece, dogs at the shrine of Aesculapius were trained to lick patients, and snake saliva was also applied to wounds. [49] Saint Roch in the Middle Ages was said to have been cured of a plague of sores by licking from his dog. [50] The Assyrian Queen Semiramis is supposed to have attempted to resurrect the slain Armenian king Ara the Beautiful by having the dog god Aralez lick his wounds. [51] In the Scottish Highlands in the nineteenth century, dog saliva was believed to be effective for treating wounds and sores. [52] In the Gospel of Luke (16:19-31), Lazarus the Beggar's sores are licked by dogs, although no curative effects are reported by the Evangelist.[ citation needed ]

Risks

As with the licking of wounds by people, wound licking by animals carries a risk of infection. Allowing pet cats to lick open wounds can cause cellulitis [53] [54] and sepsis [55] [56] due to bacterial infections. Licking of open wounds by dogs could transmit rabies if the dog is infected with rabies, [57] although this is said by the CDC to be rare. [58] Dog saliva has been reported to complicate the healing of ulcers. [59] Another issue is the possibility of an allergy to proteins in the saliva of pets, such as Fel d 1 in cat allergy and Can f 1 in dog allergy. [60] Cases of serious infection following the licking of wounds by pets include:

Idiomatic use

To "lick your wounds" means to "withdraw temporarily while recovering from a defeat" [72]

The phrase was spoken by Antony in John Dryden's seventeenth century play All for Love : [73]

They look on us at distance, and, like curs
Scaped from the lion's paws, they bay far off
And lick their wounds, and faintly threaten war.

See also

References

  1. ↑ Putro BC, Dachlan I (2018). "The effect of human saliva compared to Aloe vera on wound healing of 2 nd degree burn injury in animal models". Journal of Thee Medical Sciences (Berkala Ilmu Kedokteran). 50 (4). doi: 10.19106/JMEDSCIE/005004201801 . S2CID   198383710.
  2. ↑ Engel C (2003). Wild Health: Lessons in Natural Wellness from the Animal Kingdom . Houghton Mifflin Harcourt. ISBN   9780618340682.
  3. ↑ Szpaderska AM, Zuckerman JD, DiPietro LA (August 2003). "Differential Injury Responses in Oral Mucosal and Cutaneous Wounds". J. Dent. Res. 82 (8): 621–6. doi:10.1177/154405910308200810. PMID   12885847. S2CID   6281177.
  4. ↑ Glazko AJ, Greenberg DM (1938). "The mechanism of the action of saliva in blood coagulation". Am J Physiol. 125: 108–12. doi: 10.1152/ajplegacy.1938.125.1.108 .
  5. ↑ Berckmans RJ, Sturk A, van Tienen LM, Schaap MC, Nieuwland R (2011). "Cell-derived vesicles exposing coagulant tissue factor in saliva". Blood. 117 (11): 3172–80. doi: 10.1182/blood-2010-06-290460 . PMID   21248061.
  6. ↑ Gross PL (2011). "Salivary microvesicles clot blood". Blood. 117 (11): 2989. doi: 10.1182/blood-2011-02-332759 . PMID   21415275.
  7. ↑ Ihalin R, Loimaranta V, Tenovuo J (January 2006). "Origin, structure, and biological activities of peroxidases in human saliva". Arch Biochem Biophys. 445 (2): 261–8. doi:10.1016/j.abb.2005.07.004. PMID   16111647.
  8. ↑ Abiko Y, Nishimura M, Kaku T (2003). "Defensins in saliva and the salivary glands". Med Electron Microsc. 36 (4): 247–52. doi:10.1007/s00795-003-0225-0. PMID   16228657. S2CID   31895839.
  9. ↑ Schenkels LC, Veerman EC, Nieuw Amerongen AV (1995). "Biochemical composition of human saliva in relation to other mucosal fluids". Crit. Rev. Oral Biol. Med. 6 (2): 161–75. CiteSeerX   10.1.1.494.57 . doi:10.1177/10454411950060020501. PMID   7548622.
  10. ↑ Campo J, Perea MA, del Romero J, Cano J, Hernando V, Bascones A (May 2006). "Oral transmission of HIV, reality or fiction? An update". Oral Dis. 12 (3): 219–28. doi:10.1111/j.1601-0825.2005.01187.x. PMID   16700731. Archived from the original on 8 January 2012.
  11. ↑ Baron S, Singh I, Chopra A, Coppenhaver D, Pan J (November 2000). "Innate antiviral defenses in body fluids and tissues". Antiviral Res. 48 (2): 71–89. doi:10.1016/S0166-3542(00)00126-1. PMC   7125796 . PMID   11114410.
  12. ↑ Ashcroft GS, Lei K, Jin W, et al. (October 2000). "Secretory leukocyte protease inhibitor mediates non-redundant functions necessary for normal wound healing". Nat. Med. 6 (10): 1147–53. doi:10.1038/80489. PMID   11017147. S2CID   7738015.
  13. ↑ Kate Wong: A Protein's Healing Powers. Scientific American 2 October 2000
  14. ↑ Benjamin N, Pattullo S, Weller R, Smith L, Ormerod A (June 1997). "Wound licking and nitric oxide". Lancet. 349 (9067): 1776. doi:10.1016/S0140-6736(05)63002-4. PMID   9193412. S2CID   5405352.
  15. ↑ Zelles T, Purushotham KR, Macauley SP, Oxford GE, Humphreys-Beher MG (December 1995). "Saliva and growth factors: the fountain of youth resides in us all". J. Dent. Res. 74 (12): 1826–32. doi:10.1177/00220345950740120301. PMID   8600176. S2CID   1540916.
  16. ↑ Jahovic N, Güzel E, Arbak S, Yeğen BC (September 2004). "The healing-promoting effect of saliva on skin burn is mediated by epidermal growth factor (EGF): role of the neutrophils". Burns. 30 (6): 531–8. doi:10.1016/j.burns.2004.02.007. PMID   15302417.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  17. ↑ Pammer J, Weninger W, Mildner M, Burian M, Wojta J, Tschachler E (October 1998). "Vascular endothelial growth factor is constitutively expressed in normal human salivary glands and is secreted in the saliva of healthy individuals". J. Pathol. 186 (2): 186–91. doi:10.1002/(SICI)1096-9896(1998100)186:2<186::AID-PATH148>3.0.CO;2-J. PMID   9924435. S2CID   38787698. Archived from the original on 5 January 2013.
  18. ↑ Schrementi ME, Ferreira AM, Zender C, DiPietro LA (2008). "Site-specific production of TGF-beta in oral mucosal and cutaneous wounds". Wound Repair Regen. 16 (1): 80–6. doi:10.1111/j.1524-475X.2007.00320.x. PMID   18086295. S2CID   57591440. Archived from the original on 5 January 2013.
  19. ↑ Frank S, Stallmeyer B, Kämpfer H, Kolb N, Pfeilschifter J (August 2000). "Leptin enhances wound re-epithelialization and constitutes a direct function of leptin in skin repair". J. Clin. Invest. 106 (4): 501–9. doi:10.1172/JCI9148. PMC   380250 . PMID   10953025.
  20. ↑ Gröschl M, Topf HG, Kratzsch J, Dötsch J, Rascher W, Rauh M (April 2005). "Salivary leptin induces increased expression of growth factors in oral keratinocytes". J. Mol. Endocrinol. 34 (2): 353–66. doi: 10.1677/jme.1.01658 . PMID   15821102.
  21. ↑ Costigan DC, Guyda HJ, Posner BI (May 1988). "Free insulin-like growth factor I (IGF-I) and IGF-II in human saliva". J. Clin. Endocrinol. Metab. 66 (5): 1014–8. doi:10.1210/jcem-66-5-1014. PMID   3360895.
  22. ↑ Todorović V, Pesko P, Micev M, et al. (October 2008). "Insulin-like growth factor-I in wound healing of rat skin". Regul. Pept. 150 (1–3): 7–13. doi:10.1016/j.regpep.2008.05.006. PMID   18597865. S2CID   45969233.
  23. ↑ Sugiura T, Nakane S, Kishimoto S, Waku K, Yoshioka Y, Tokumura A (December 2002). "Lysophosphatidic acid, a growth factor-like lipid, in the saliva". J. Lipid Res. 43 (12): 2049–55. doi: 10.1194/jlr.M200242-JLR200 . PMID   12454265.
  24. ↑ Balazs L, Okolicany J, Ferrebee M, Tolley B, Tigyi G (1 February 2001). "Topical application of the phospholipid growth factor lysophosphatidic acid promotes wound healing in vivo". Am. J. Physiol. Regul. Integr. Comp. Physiol. 280 (2): R466–72. doi:10.1152/ajpregu.2001.280.2.R466. PMID   11208576. S2CID   13089523.
  25. ↑ Pogrel MA, Low MA, Stern R (June 2003). "Hyaluronan (hyaluronic acid) and its regulation in human saliva by hyaluronidase and its inhibitors" (PDF). J Oral Sci. 45 (2): 85–91. doi: 10.2334/josnusd.45.85 . PMID   12930131.
  26. ↑ Li AK, Koroly MJ, Schattenkerk ME, Malt RA, Young M (July 1980). "Nerve growth factor: acceleration of the rate of wound healing in mice". Proc. Natl. Acad. Sci. U.S.A. 77 (7): 4379–81. Bibcode:1980PNAS...77.4379L. doi: 10.1073/pnas.77.7.4379 . PMC   349838 . PMID   6933491.
  27. ↑ Kawamoto K, Matsuda H (2004). "Nerve growth factor and wound healing". NGF and Related Molecules in Health and Disease. Progress in Brain Research. Vol. 146. pp. 369–84. doi:10.1016/S0079-6123(03)46023-8. ISBN   978-0-444-51472-1. PMID   14699974.{{cite book}}: |journal= ignored (help)
  28. ↑ Nam JW, Chung JW, Kho HS, Chung SC, Kim YK (March 2007). "Nerve growth factor concentration in human saliva". Oral Dis. 13 (2): 187–92. doi:10.1111/j.1601-0825.2006.01265.x. PMID   17305621. Archived from the original on 10 October 2012.
  29. ↑ Oudhoff MJ, Bolscher JG, Nazmi K, et al. (November 2008). "Histatins are the major wound-closure stimulating factors in human saliva as identified in a cell culture assay". FASEB J. 22 (11): 3805–12. doi: 10.1096/fj.08-112003 . PMID   18650243. S2CID   19797007.
  30. ↑ Wright K (28 December 2008). "Top 100 Stories of 2008 #62: Researchers Discover Why Wound-Licking Works". Discover Magazine.
  31. ↑ Sørensen OE, Cowland JB, Theilgaard-Mönch K, Liu L, Ganz T, Borregaard N (1 June 2003). "Wound healing and expression of antimicrobial peptides/polypeptides in human keratinocytes, a consequence of common growth factors". J. Immunol. 170 (11): 5583–9. doi: 10.4049/jimmunol.170.11.5583 . PMID   12759437.
  32. ↑ Wisner A, Dufour E, Messaoudi M, et al. (November 2006). "Human Opiorphin, a natural antinociceptive modulator of opioid-dependent pathways". Proc. Natl. Acad. Sci. U.S.A. 103 (47): 17979–84. Bibcode:2006PNAS..10317979W. doi: 10.1073/pnas.0605865103 . PMC   1693858 . PMID   17101991.
  33. ↑ Federation of American Societies for Experimental Biology. "Licking Your Wounds: Scientists Isolate Compound in Human Saliva That Speeds Wound Healing." ScienceDaily. ScienceDaily, 24 July 2008.
  34. ↑ Hart BL, Powell KL (September 1990). "Antibacterial properties of saliva: role in maternal periparturient grooming and in licking wounds". Physiol. Behav. 48 (3): 383–6. doi:10.1016/0031-9384(90)90332-X. PMID   2125128. S2CID   27717690.
  35. ↑ Bodner L, Knyszynski A, Adler-Kunin S, Danon D (1991). "The effect of selective desalivation on wound healing in mice". Exp. Gerontol. 26 (4): 357–63. doi:10.1016/0531-5565(91)90047-P. PMID   1936194. S2CID   21897174.
  36. ↑ Hutson JM, Niall M, Evans D, Fowler R (June 1979). "Effect of salivary glands on wound contraction in mice". Nature. 279 (5716): 793–5. Bibcode:1979Natur.279..793H. doi:10.1038/279793a0. PMID   450129. S2CID   4273490.
  37. ↑ Bodner L (1991). "Effect of parotid submandibular and sublingual saliva on wound healing in rats". Comp Biochem Physiol A. 100 (4): 887–90. doi:10.1016/0300-9629(91)90309-Z. PMID   1685381.
  38. ↑ Dittus WP, Ratnayeke SM (1989). "Individual and social behavioral responses to injury in wild toque macaques (Macaca Sinica)". International Journal of Primatology. 10 (3): 215–34. doi:10.1007/BF02735201. S2CID   25815676.
  39. ↑ Shumaker AK, Angus JC, Coyner KS, Loeffler DG, Rankin SC, Lewis TP (October 2008). "Microbiological and histopathological features of canine acral lick dermatitis". Veterinary Dermatology. 19 (5): 288–98. doi:10.1111/j.1365-3164.2008.00693.x. PMID   18699812.
  40. ↑ Mansfield K, McElhinney L, Hübschle O, et al. (2006). "A molecular epidemiological study of rabies epizootics in kudu (Tragelaphus strepsiceros) in Namibia". BMC Vet. Res. 2: 2. doi: 10.1186/1746-6148-2-2 . PMC   1382222 . PMID   16412222.
  41. ↑ Fabrini P, Isoleri, Antonio (1900). The life of St. Mary Magdalen De-Pazzi : Florentine noble, sacred Carmelite virgin. Philadelphia.{{cite book}}: CS1 maint: location missing publisher (link)
  42. ↑ Eve E (2008). "Spit in Your Eye: The Blind Man of Bethsaida and the Blind Man of Alexandria". New Testament Studies. 54: 1–17. doi:10.1017/S0028688508000015 (inactive 18 November 2024). S2CID   170335886.{{cite journal}}: CS1 maint: DOI inactive as of November 2024 (link)
  43. ↑ "Pliny Natural History: Book XXVIII: Chapter XXIII". Loeb Classical Library.
  44. ↑ Köstenberger AJ (December 2004). John. Baker Academic. p. 283. ISBN   978-0-8010-2644-7.
  45. ↑ Weil HP, Fischer-Brügge U, Koch P (April 2002). "Potential hazard of wound licking" (PDF). N. Engl. J. Med. 346 (17): 1336. doi:10.1056/NEJM200204253461721. PMID   11973376.
  46. ↑ Hatfield G (2004). Encyclopedia of Folk Medicine: Old World and New World Traditions. ABC-CLIO. ISBN   9781576078747.
  47. ↑ Daniels CL, C. M. Stevans (2003). Encyclopfdia of Superstitions, Folklore, and the Occult Sciences of the World (Volume II). Minerva Group Inc. p. 668. ISBN   9781410209153.
  48. ↑ The Aberdeen Bestiary, a thirteenth-century English illuminated manuscript
  49. ↑ Angeletti LR, Agrimi U, Curia C, French D, Mariani-Costantini R (July 1992). "Healing rituals and sacred serpents". Lancet. 340 (8813): 223–5. doi:10.1016/0140-6736(92)90480-Q. PMID   1353146. S2CID   23136986.
  50. ↑ Serpell J (1996). In the Company of Animals: A Study of Human-animal Relationships. Cambridge University Press. ISBN   9780521577793.
  51. ↑ Ananikian M (1925). Armenian Mythology in The Mythology of All Races Volume VII. New York: Archaeological Institute of America, Marshall Jones Co.
  52. ↑ Gregor W (1881). Notes on the Folk-Lore of the North-East of Scotland. Forgotten Books. p. 251. ISBN   978-1-60506-178-8. Archived from the original on 25 July 2011. Retrieved 13 February 2009.
  53. ↑ DiNubile MJ, Lipsky BA (June 2004). "Complicated infections of skin and skin structures: when the infection is more than skin deep" (PDF). J. Antimicrob. Chemother. 53 (Suppl 2): ii37–50. doi: 10.1093/jac/dkh202 . PMID   15150182.
  54. ↑ Yu GV, Boike AM, Hladik JR (1995). "An unusual case of diabetic cellulitis due to Pasturella multocida". J Foot Ankle Surg. 34 (1): 91–5. doi:10.1016/S1067-2516(09)80109-9. PMID   7780401.
  55. ↑ Hazouard E, Ferrandière M, Lanotte P, Le Marcis L, Cattier B, Giniès G (September 2000). "[Septic shock caused by Pasteurella multocida in alcoholic patients. Probable contamination of leg ulcers by the saliva of the domestic cats]". Presse Med (in French). 29 (16): 1455–7. PMID   11039085.
  56. ↑ Valtonen M, Lauhio A, Carlson P, et al. (June 1995). "Capnocytophaga canimorsus septicemia: fifth report of a cat-associated infection and five other cases". Eur. J. Clin. Microbiol. Infect. Dis. 14 (6): 520–3. doi:10.1007/BF02113430. PMID   7588825. S2CID   631013.
  57. ↑ Phanuphak P, Ubolyam S, Sirivichayakul S (1994). "Should travellers in rabies endemic areas receive pre-exposure rabies immunization?". Ann Med Interne. 145 (6): 409–11. PMID   7864502.
  58. ↑ Centers for Disease Control and Prevention (CDC) (July 2004). "Investigation of rabies infections in organ donor and transplant recipients—Alabama, Arkansas, Oklahoma, and Texas, 2004". MMWR Morb. Mortal. Wkly. Rep. 53 (26): 586–9. PMID   15241303.
  59. ↑ Knowles J (27 January – 2 February 2000). "Dog saliva complicates the healing of ulcers". Nurs Times. 96 (4 Suppl): 8. PMID   10827733.
  60. ↑ Konieczny A, Morgenstern JP, Bizinkauskas CB, et al. (December 1997). "The major dog allergens, Can f 1 and Can f 2, are salivary lipocalin proteins: cloning and immunological characterization of the recombinant forms". Immunology. 92 (4): 577–86. doi:10.1046/j.1365-2567.1997.00386.x. PMC   1364166 . PMID   9497502.
  61. ↑ Dupuy O, Garrabé E, Bordier L, Boyer B, Goasguen O, Mayaudon H, Bauduceau B (October 2006). "Pasteurella dagmatis spondylodiscitis in a diabetic patient". Rev Méd Interne (in French). 27 (10): 803–4. doi:10.1016/j.revmed.2006.05.018. PMID   16978746.
  62. ↑ Heym B, Jouve F, Lemoal M, Veil-Picard A, Lortat-Jacob A, Nicolas-Chanoine MH (October 2006). "Pasteurella multocida infection of a total knee arthroplasty after a "dog lick"". Knee Surg Sports Traumatol Arthrosc. 14 (10): 993–7. doi:10.1007/s00167-005-0022-5. PMID   16468067. S2CID   7446046.
  63. ↑ Low SC, Greenwood JE (2008). "Capnocytophaga canimorsus: infection, septicaemia, recovery and reconstruction". Journal of Medical Microbiology. 57 (7): 901–903. doi: 10.1099/jmm.0.47756-0 . ISSN   0022-2615. PMID   18566152.
  64. ↑ Low SC, Greenwood JE (July 2008). "Capnocytophaga canimorsus: infection, septicaemia, recovery and reconstruction". J. Med. Microbiol. 57 (Pt 7): 901–3. doi: 10.1099/jmm.0.47756-0 . PMID   18566152.
  65. ↑ Staff writers (25 July 2008). "Woman loses leg, fingers, toes from dog lick". Herald Sun. Retrieved 30 January 2009.
  66. ↑ Anderson CE, Jayawardene SA, Carmichael P (2000). "A lick may be as bad as a bite: irreversible acute renal failure". Nephrol Dial Transplant. 15 (11): 1883–4. doi: 10.1093/ndt/15.11.1883 . PMID   11071985.
  67. ↑ Ko Chang, L. K. Siu, Yen-Hsu Chen, Po-Liang Lu, Tun-Chieh Chen, Hsiao-Chen Hsieh, Chun-Lu Lin (2007). "Fatal Pasteurella multocida septicemia and necrotizing fasciitis related with wound licked by a domestic dog". Scandinavian Journal of Infectious Diseases. 39 (2): 167–70. doi:10.1080/00365540600786572. PMID   17366037. S2CID   29739347.
  68. ↑ Godey B, Morandi X, Bourdinière J, Heurtin C (1999). "Beware of dogs licking ears". Lancet. 354 (9186): 1267–8. doi:10.1016/S0140-6736(99)04197-5. PMID   10520644. S2CID   34432193.
  69. ↑ Chun ML, Buekers TE, Sood AK, Sorosky JI (April 2003). "Postoperative wound infection with Pasteurella multocida from a pet cat". Am J Obstet Gynecol. 188 (4): 1115–6. doi:10.1067/mob.2003.266. PMID   12712125.
  70. ↑ Bryant BJ, Conry-Cantilena C, Ahlgren A, Felice A, Stroncek DF, Gibble J, Leitman SF (November 2007). "Pasteurella multocida bacteremia in asymptomatic plateletpheresis donors: a tale of two cats". Transfusion. 47 (11): 1984–9. doi:10.1111/j.1537-2995.2007.01421.x. PMID   17958526. S2CID   25123364. Archived from the original on 5 January 2013.
  71. ↑ Wade T, Booy R, Teare EL, Kroll S (November 1999). "Pasteurella multocida meningitis in infancy – (a lick may be as bad as a bite)". Eur J Pediatr. 158 (11): 875–8. doi:10.1007/s004310051232. PMID   10541939. S2CID   24293826.
  72. ↑ wikt:To lick one's wounds
  73. ↑ Dryden J (1677). All for Love, or the World Well Lost. Archived from the original on 2 October 2015. Retrieved 27 March 2009.
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