(R)-limonene synthase

Not to be confused with (4S)-limonene synthase.

(R)-limonene synthase
Identifiers
EC no.	4.2.3.20
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

The enzyme (R)-limonene synthase (EC 4.2.3.20) catalyzes the reversible chemical reaction

• geranyl diphosphate ${\displaystyle \rightleftharpoons }$ (+)-(4R)-limonene + diphosphate.

Description

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is Geranyl-diphosphate diphosphate-lyase [cyclizing, (+)-(4R)-limonene-forming]. Other names in common use include Limonene synthase, and Geranyldiphosphate diphosphate lyase [(+)-(R)-limonene-forming].

The enzyme participates in monoterpenoid biosynthesis and is localized to Leucoplasts of oil gland secretory cells. ^[1]

References

1. Turner G, Gershenzon J, Nielson EE, Froehlich JE, Croteau R (July 1999). "Limonene synthase, the enzyme responsible for monoterpene biosynthesis in peppermint, is localized to leucoplasts of oil gland secretory cells". Plant Physiology. 120 (3): 879–86. doi:10.1104/pp.120.3.879. PMC   59327 . PMID   10398724.

Further reading

• Bouwmeester HJ, Gershenzon J, Konings MC, Croteau R (July 1998). "Biosynthesis of the monoterpenes limonene and carvone in the fruit of caraway. I. Demonstration Of enzyme activities and their changes with development". Plant Physiology. 117 (3): 901–12. doi: 10.1104/pp.117.3.901 . PMC   34944 . PMID   9662532.
• Lücker J, El Tamer MK, Schwab W, Verstappen FW, van der Plas LH, Bouwmeester HJ, Verhoeven HA (July 2002). "Monoterpene biosynthesis in lemon (Citrus limon). cDNA isolation and functional analysis of four monoterpene synthases". European Journal of Biochemistry. 269 (13): 3160–71. doi: 10.1046/j.1432-1033.2002.02985.x . PMID   12084056.