1-Deoxy-11beta-hydroxypentalenate dehydrogenase

1-deoxy-11beta-hydroxypentalenate dehydrogenase
Identifiers
EC no.	1.1.1.340
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

1-deoxy-11beta-hydroxypentalenate dehydrogenase (EC 1.1.1.340, 1-deoxy-11beta-hydroxypentalenic acid dehydrogenase, ptlF (gene), penF (gene name)) is an enzyme with systematic name 1-deoxy-11beta-hydroxypentalenate:NAD⁺ oxidoreductase. ^[1] This enzyme catalyses the following chemical reaction

1-deoxy-11β-hydroxypentalenic acid

+ NAD⁺

 

 

 

H⁺

 

H⁺

 

1-deoxy-11-oxopentalenic acid

+ NADH

 

This enzyme from the bacterium Streptomyces avermitilis participates in pentalenolactone biosynthesis. ^[2]

References

1. You Z, Omura S, Ikeda H, Cane DE (March 2007). "Pentalenolactone biosynthesis: Molecular cloning and assignment of biochemical function to PtlF, a short-chain dehydrogenase from Streptomyces avermitilis, and identification of a new biosynthetic intermediate". Archives of Biochemistry and Biophysics. 459 (2): 233–40. doi:10.1016/j.abb.2006.11.016. PMC   1857356 . PMID   17178094.
2. Enzyme 1.1.1.340 at KEGG Pathway Database.

External links

• 1-deoxy-11beta-hydroxypentalenate+dehydrogenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)