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In mathematics, the classification of finite simple groups is a result of group theory stating that every finite simple group is either cyclic, or alternating, or belongs to a broad infinite class called the groups of Lie type, or else it is one of twenty-six or twenty-seven exceptions, called sporadic. The proof consists of tens of thousands of pages in several hundred journal articles written by about 100 authors, published mostly between 1955 and 2004.
Inositol trisphosphate or inositol 1,4,5-trisphosphate abbreviated InsP3 or Ins3P or IP3 is an inositol phosphate signaling molecule. It is made by hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2), a phospholipid that is located in the plasma membrane, by phospholipase C (PLC). Together with diacylglycerol (DAG), IP3 is a second messenger molecule used in signal transduction in biological cells. While DAG stays inside the membrane, IP3 is soluble and diffuses through the cell, where it binds to its receptor, which is a calcium channel located in the endoplasmic reticulum. When IP3 binds its receptor, calcium is released into the cytosol, thereby activating various calcium regulated intracellular signals.
The year 1975 in science and technology involved some significant events, listed below.
Luc Montagnier was a French virologist and joint recipient, with Françoise Barré-Sinoussi and Harald zur Hausen, of the 2008 Nobel Prize in Physiology or Medicine for his discovery of the human immunodeficiency virus (HIV). He worked as a researcher at the Pasteur Institute in Paris and as a full-time professor at Shanghai Jiao Tong University in China.
Baryonyx is a genus of theropod dinosaur which lived in the Barremian stage of the Early Cretaceous period, about 130–125 million years ago. The first skeleton was discovered in 1983 in the Smokejack Clay Pit, of Surrey, England, in sediments of the Weald Clay Formation, and became the holotype specimen of Baryonyx walkeri, named by palaeontologists Alan J. Charig and Angela C. Milner in 1986. The generic name, Baryonyx, means "heavy claw" and alludes to the animal's very large claw on the first finger; the specific name, walkeri, refers to its discoverer, amateur fossil collector William J. Walker. The holotype specimen is one of the most complete theropod skeletons from the UK, and its discovery attracted media attention. Specimens later discovered in other parts of the United Kingdom and Iberia have also been assigned to the genus, though many have since been moved to new genera.
Inositol trisphosphate receptor (InsP3R) is a membrane glycoprotein complex acting as a Ca2+ channel activated by inositol trisphosphate (InsP3). InsP3R is very diverse among organisms, and is necessary for the control of cellular and physiological processes including cell division, cell proliferation, apoptosis, fertilization, development, behavior, learning and memory. Inositol triphosphate receptor represents a dominant second messenger leading to the release of Ca2+ from intracellular store sites. There is strong evidence suggesting that the InsP3R plays an important role in the conversion of external stimuli to intracellular Ca2+ signals characterized by complex patterns relative to both space and time, such as Ca2+ waves and oscillations.
Sir Michael John Berridge (22 October 1938 - 13 February 2020) was a British physiologist and biochemist. He was known for his work on cell signaling, in particular the discovery that inositol trisphosphate acts as a second messenger, linking events at the plasma membrane with the release of calcium ions (Ca2+) within the cell.
2-Aminoethoxydiphenyl borate (2-APB) is a chemical that acts to inhibit both IP3 receptors and TRP channels (although it activates TRPV1, TRPV2, & TRPV3 at higher concentrations). In research it is used to manipulate intracellular release of calcium ions (Ca2+) and modify TRP channel activity, although the lack of specific effects make it less than ideal under some circumstances. Additionally, there is evidence that 2-APB acts directly to inhibit gap junctions made of connexin. Increasing evidence showed that 2-APB is a powerful modifier of store-operated calcium channels (SOC) function, low concentration of 2-APB can enhance SOC while high concentration induces a transient increase followed by complete inhibition.
Inositol-trisphosphate 3-kinase B is an enzyme that in humans is encoded by the ITPKB gene.
Inositol 1,4,5-trisphosphate receptor type 1 is a protein that in humans is encoded by the ITPR1 gene.
SH2-domain containing Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 is an enzyme that in humans is encoded by the INPPL1 gene.
Inositol (1,4,5) trisphosphate 3-kinase (EC 2.7.1.127), abbreviated here as ITP3K, is an enzyme that facilitates a phospho-group transfer from adenosine triphosphate to 1D-myo-inositol 1,4,5-trisphosphate. This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:1D-myo-inositol-1,4,5-trisphosphate 3-phosphotransferase. ITP3K catalyzes the transfer of the gamma-phosphate from ATP to the 3-position of inositol 1,4,5-trisphosphate to form inositol 1,3,4,5-tetrakisphosphate. ITP3K is highly specific for the 1,4,5-isomer of IP3, and it exclusively phosphorylates the 3-OH position, producing Ins(1,3,4,5)P4, also known as inositol tetrakisphosphate or IP4.
Inositol-trisphosphate 3-kinase A is an enzyme that in humans is encoded by the ITPKA gene.
Robert Charles Gallo is an American biomedical researcher. He is best known for his role in establishing the human immunodeficiency virus (HIV) as the infectious agent responsible for acquired immune deficiency syndrome (AIDS) and in the development of the HIV blood test, and he has been a major contributor to subsequent HIV research.
Inositol 1,4,5-trisphosphate receptor, type 2, also known as ITPR2, is a protein which in humans is encoded by the ITPR2 gene. The protein encoded by this gene is both a receptor for inositol triphosphate and a calcium channel.
Inositol 1,4,5-trisphosphate receptor, type 3, also known as ITPR3, is a protein which in humans is encoded by the ITPR3 gene. The protein encoded by this gene is both a receptor for inositol triphosphate and a calcium channel.
Jean-Claude Chermann is a French virologist who managed the research team which, by 1983, under the administrative supervision of Luc Montagnier, had discovered the virus associated with AIDS. Whereas second author of this initial publication and obviously involved as team manager in this discovery, he had been omitted from the Nobel Prize attributed to its colleagues. In 2008, as chairman of the support committee for the attribution of the Nobel Prize in medicine to Jean-Claude Chermann, Bernard Le Grelle, a political consultant, campaigned for the official recognition of this oversight with the Nobel committee by bringing together more than 700 doctors, professors and scientists . The virus was named lymphadenopathy-associated virus, or LAV. A year later, a team led by Robert Gallo of the United States confirmed the discovery of the virus, but renamed it human T-lymphotropic virus type III (HTLV-III).
Continuum was a magazine published by an activist group of the same name who denied the existence of HIV/AIDS.
The enzyme inositol-polyphosphate 5-phosphatase (EC 3.1.3.56), systematic name 1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase, catalyses the following reactions:
Baryonychinae is an extinct clade or subfamily of spinosaurids from the Early Cretaceous (Valanginian-Albian) of Britain, Portugal, and Niger. The clade was named by Charig & Milner in 1986 and defined by Sereno et al. in 1998 and Holtz et al. in 2004 as all taxa more closely related to Baryonyx walkeri than to Spinosaurus aegyptiacus.
References
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- ↑ Greener, Mark (2005). "MAbs Turn 30". The Scientist. 19 (3): 14–16.
- ↑ Klotz S.A.; Drutz D.J.; Tam M.R.; Reed K.H. (1983). "Hemorrhagic proctitis due to lymphogranuloma venereum serogroup L2: Diagnosis by fluorescent monoclonal antibody". The New England Journal of Medicine . 308 (26): 1563–1565. doi:10.1056/NEJM198306303082604. PMID 6602293.
- ↑ Hanukoglu I, Fuchs E (July 1983). "The cDNA sequence of a Type II cytoskeletal keratin reveals constant and variable structural domains among keratins". Cell. 33 (3): 915–924. doi:10.1016/0092-8674(83)90034-X. PMID 6191871. S2CID 21490380.
- ↑ Streb, H.; Irvine, R. F.; Berridge, M. J.; Schulz, I. (November 3, 1983). "Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate". Nature . 306 (5938): 67–9. Bibcode:1983Natur.306...67S. doi:10.1038/306067a0. PMID 6605482. S2CID 4359904.
- ↑ Chadabe, Joel (May 1, 2000). "The Electronic Century, Part IV: The Seeds of the Future". Electronic Musician. 16 (5). Penton Media. Archived from the original on September 28, 2012. Retrieved November 28, 2012.
- ↑ On the net.unix-wizards and net.usoft newsgroups.
- ↑ Allen, Roy A. (2001). "Chapter 12: Microsoft in the 1980s" (PDF). A History of the Personal Computer: the People and the Technology. Allan Publishing. pp. 12/25–12/26. ISBN 978-0-9689108-0-1 . Retrieved November 7, 2010.
- ↑ "Microsoft Office online, Getting to know you...again: The Ribbon". Archived from the original on May 11, 2011. Retrieved June 8, 2011.
- ↑ "The history of branding, Microsoft history". Archived from the original on May 28, 2009. Retrieved June 8, 2011.
- ↑ Pollack, Andrew (August 25, 1983). "Computerizing Magazines". The New York Times . Archived from the original on May 12, 2011. Retrieved June 8, 2011.
- ↑ Zetter, Kim (November 10, 2009). "This Day in Tech – Nov. 10, 1983: Computer 'Virus' Is Born". Wired . Retrieved January 28, 2012.
- ↑ Maxime Crochemore; Renaud Vérin (1997). On compact directed acyclic word graphs. Lecture Notes in Computer Science. pp. 192–211. CiteSeerX 10.1.1.13.6892 . doi:10.1007/3-540-63246-8_12. ISBN 978-3-540-69242-3. Wikidata Q90413885.
{{cite book}}:|journal=ignored (help) - ↑ Gorenstein, Daniel (1983). The classification of finite simple groups. Vol. 1. Groups of noncharacteristic 2 type. The University Series in Mathematics. New York: Plenum Press. ISBN 978-0-306-41305-6. MR 0746470.
- ↑ "About". UCSF . Retrieved June 10, 2020.
- ↑ Charig, A. J.; Milner, A. C. (1986). "Baryonyx, a remarkable new theropod dinosaur". Nature. 324 (6095): 359–361. Bibcode:1986Natur.324..359C. doi:10.1038/324359a0. PMID 3785404. S2CID 4343514.
- ↑ Chang, Kenneth (July 5, 2022). "Fields Medals in Mathematics Won by Four Under Age 40". The New York Times . Archived from the original on July 5, 2022. Retrieved July 5, 2022.