2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase

2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase
Identifiers
EC no.	1.1.1.302
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase (EC 1.1.1.302, 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase, MjaRED, MJ0671 (gene)) is an enzyme with systematic name 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one:NAD(P)⁺ oxidoreductase. ^{[1] [2]} This enzyme catalyses the following chemical reaction

2,5-diamino-6-(5-phosphono)ribitylamino-4(3H)-pyrimidinone

+ NAD⁺

 

 

 

H⁺

 

H⁺

 

2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine

+ NADH

 

The reaction proceeds in the opposite direction. A step in riboflavin biosynthesis, NADPH and NADH functions equally well as a reductant. ^[3]

References

1. Graupner M, Xu H, White RH (April 2002). "The pyrimidine nucleotide reductase step in riboflavin and F(420) biosynthesis in archaea proceeds by the eukaryotic route to riboflavin". Journal of Bacteriology. 184 (7): 1952–7. doi:10.1128/JB.184.7.1952-1957.2002. PMC   134922 . PMID   11889103.
2. Chatwell L, Krojer T, Fidler A, Römisch W, Eisenreich W, Bacher A, Huber R, Fischer M (June 2006). "Biosynthesis of riboflavin: structure and properties of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase of Methanocaldococcus jannaschii". Journal of Molecular Biology. 359 (5): 1334–51. doi:10.1016/j.jmb.2006.04.045. PMID   16730025.
3. Enzyme 1.1.1.302 at KEGG Pathway Database.

External links

• 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone+5'-phosphate+reductase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)