2'-hydroxydaidzein reductase

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2'-hydroxydaidzein reductase
Identifiers
EC no. 1.3.1.51
CAS no. 126125-01-7
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
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PMC articles
PubMed articles
NCBI proteins

In enzymology, 2'-hydroxydaidzein reductase (EC 1.3.1.51) is an enzyme that catalyzes the chemical reaction

 
 
H+
 
2'-hydroxydaidzein reductase
H+
 
 
 

The three substrates of this enzyme are 2'-hydroxydaidzein, reduced nicotinamide adenine dinucleotide phosphate (NADPH), and a proton. Its products are 2'-hydroxy-2,3-dihydrodaidzein and oxidised NADP+. [1] [2]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2'-hydroxy-2,3-dihydrodaidzein:NADP+ 2'-oxidoreductase. Other names in common use include NADPH:2'-hydroxydaidzein oxidoreductase, HDR, and 2'-hydroxydihydrodaidzein:NADP+ 2'-oxidoreductase. This enzyme participates in isoflavonoid biosynthesis.

References

  1. Enzyme 1.3.1.51 at KEGG Pathway Database.
  2. Fischer D, Ebenau-Jehle C, Grisebach H (1990). "Phytoalexin synthesis in soybean: purification and characterization of NADPH:2'-hydroxydaidzein oxidoreductase from elicitor-challenged soybean cell cultures". Arch. Biochem. Biophys. 276 (2): 390–5. doi:10.1016/0003-9861(90)90737-J. PMID   2306102.