Andy Ram and Vera Zvonareva defeated Bob Bryan and Venus Williams in the final, 6–3, 6–2 to win the mixed doubles tennis title at the 2006 Wimbledon Championships.
Martina Navratilova and Bob Bryan defeated Květa Peschke and Martin Damm in the final, 6–2, 6–3 to win the mixed doubles tennis title at the 2006 US Open. It was Navratilova's 59th and final major title, 32 years after her first.
Elena Likhovtseva and Daniel Nestor won the mixed doubles title at the 2007 Australian Open tennis tournament, defeating Victoria Azarenka and Max Mirnyi in the final 6–4, 6–4.
Katarina Srebotnik and Bob Bryan were the defending champions, but Srebtonik did not compete in the Mixed Doubles tournament at this U.S. Open. Bryan partnered Vera Zvonareva, and successfully defended the title, defeating Alicia Molik and Todd Woodbridge in the final 6–3, 6–4.
Martina Hingis and Mahesh Bhupathi defeated Elena Likhovtseva and Daniel Nestor in the final, 6–3, 6–3 to win the mixed doubles tennis title at the 2006 Australian Open. With the win, Bhupathi completed the career Grand Slam in mixed doubles, becoming the 14th player to do so. It was Hingis' first major mixed doubles title; she would later also complete the career Grand Slam in the discipline.
Wayne and Cara Black were the defending champions but lost in the second round to Mahesh Bhupathi and Mary Pierce.
Leander Paes and Martina Navratilova were the defending champions but lost in the third round to Wayne and Cara Black.
Martina Navratilova and Bob Bryan were the defending champions, but Navratilova retired from the sport at the end of 2006. Bryan partnered Tatiana Golovin, and lost in the second round to Sania Mirza and Mahesh Bhupathi.
Sun Tiantian and Nenad Zimonjić won the mixed doubles title at the 2008 Australian Open, defeating Sania Mirza and Mahesh Bhupathi in the final 7–6(7–4), 6–4.
Vera Zvonareva and Bob Bryan were the defending champions, but Zvonareva did not participate in this U.S. Open due to injury. Bryan partnered Rennae Stubbs, and the pair lost in the quarterfinals to Corina Morariu and Mike Bryan.
The 1999 US Open mixed doubles was the mixed doubles event of the hundred-and-ninth edition of the US Open, the fourth and last Grand Slam of the year. Serena Williams and Max Mirnyi were the defending champions but did not compete that year.
Defending champions Lisa Raymond and Mike Bryan lost in the first round to Arantxa Sánchez Vicario and Daniel Nestor.
Leoš Friedl and Daniela Hantuchová were the defending champions but decided not to play together. Friedl played with Tina Križan and lost in first round to Mike Bryan and Liezel Huber, while Hantuchová competed with Kevin Ullyett.
The mixed doubles of the 2002 Australian Open was held for the 58th time since the first tournament back in 1922. Heading into the tournament, Corina Morariu and Ellis Ferreira were the defending champions, but could not defend their title. While Morariu did not compete this year, Ferreira partnered with Cara Black and lost in the first Round to Rita Grande and Jeff Tarango in three sets.
Rennae Stubbs and Todd Woodbridge were the defending champions, but lost in the first round to Martina Navratilova and Leander Paes.
Patricia Tarabini and Javier Frana were the defending champions, but lost in third round to Rachel McQuillan and David Macpherson.
Mahesh Bhupathi and Elena Likhovtseva were the defending champions but decided not to play together. Bhupathi played with Paola Suárez and lost in third round to Nenad Zimonjić and Iroda Tulyaganova, while Likhovtseva competed with Bob Bryan and lost in second round to Andy Ram and Anastasia Rodionova.
Lisa Raymond and Mike Bryan were the defending champions, but lost in the quarterfinals to Cara Black and Wayne Black.
Martina Navratilova and Leander Paes defeated Eleni Daniilidou and Todd Woodbridge in the final, 6–4, 7–5 to win the mixed doubles tennis title at the 2003 Australian Open. It was Navratilova's first Australian Open mixed doubles title and eighth mixed doubles title overall, and the first Australian Open and second mixed doubles title for Paes. With the win, Navratilova became the fourth woman in history to complete the career Grand Slam in mixed doubles, and became only the third player in history to complete the "Boxed Set".
Virginia Ruano Pascual and Tomás Carbonell were the defending champions, but had different outcomes. Ruano Pascual teamed up with Gastón Etlis and lost in second round to Cara and Wayne Black, while Carbonell did not compete this year due to retiring from professional tennis in 2001.
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Lisa Raymond 
Elena Likhovtseva 
Mahesh Bhupathi 
