| Mixed doubles | |
|---|---|
| 2016 US Open | |
| Champions |  Laura Siegemund  Mate Pavić |
| Runners-up |  CoCo Vandeweghe Rajeev Ram |
| Score | 6–4, 6–4 |
Martina Hingis and Leander Paes were the defending champions, but lost in the second round to CoCo Vandeweghe and Rajeev Ram.
Laura Siegemund and Mate Pavić won the title, defeating Vandeweghe and Ram in the final, 6–4, 6–4. [1]
Sania Mirza / Ivan Dodig (second round)
Yaroslava Shvedova / 
Bruno Soares (quarterfinals) Bethanie Mattek-Sands / 
Horia Tecău (withdrew) Raquel Atawo / 
Jean-Julien Rojer (first round)
Chan Hao-ching / 
Max Mirnyi (second round)
Andrea Hlaváčková / 
Łukasz Kubot (second round) CoCo Vandeweghe / Rajeev Ram (final) Lucie Hradecká / Marcin Matkowski (first round)| Semifinals | Final | ||||||||||||
| 7 | CoCo Vandeweghe Rajeev Ram | 77 | 6 | ||||||||||
Anna-Lena Grönefeld  Robert Farah | 64 | 4 | |||||||||||
| 7 | CoCo Vandeweghe Rajeev Ram | 4 | 4 | ||||||||||
| Laura Siegemund Mate Pavić | 6 | 6 | |||||||||||
| Laura Siegemund Mate Pavić | 77 | 7 | |||||||||||
Chan Yung-jan  Nenad Zimonjić | 65 | 5 | |||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | S Mirza I Dodig | 6 | 6 | ||||||||||||||||||||||||
| WC | T Townsend D Young | 4 | 4 | 1 | S Mirza I Dodig | 3 | 4 | ||||||||||||||||||||
| B Krejčíková M Draganja | 6 | 6 | B Krejčíková M Draganja | 6 | 6 | ||||||||||||||||||||||
| Alt |  J Ostapenko  O Marach | 1 | 4 | B Krejčíková M Draganja | 3 | 3 | |||||||||||||||||||||
| WC |  M Hingis L Paes | 6 | 6 | 7 | C Vandeweghe R Ram | 6 | 6 | ||||||||||||||||||||
| WC | S Vickery F Tiafoe | 3 | 2 | WC | M Hingis L Paes | 61 | 6 | [11] | |||||||||||||||||||
 An Rodionova JS Cabal | 3 | 6 | [8] | 7 | C Vandeweghe R Ram | 77 | 3 | [13] | |||||||||||||||||||
| 7 | C Vandeweghe R Ram | 6 | 2 | [10] | 7 | C Vandeweghe R Ram | 77 | 6 | |||||||||||||||||||
| 4 | R Atawo J-J Rojer | 64 | 7 | [4] | A-L Grönefeld R Farah | 64 | 4 | ||||||||||||||||||||
M Krajicek  D Inglot | 77 | 5 | [10] | M Krajicek D Inglot | 4 | 6 | [8] | ||||||||||||||||||||
| A-L Grönefeld R Farah | 7 | 6 | A-L Grönefeld R Farah | 6 | 3 | [10] | |||||||||||||||||||||
 A Klepač  T Huey | 5 | 4 | A-L Grönefeld R Farah | 1 | 6 | [10] | |||||||||||||||||||||
| WC | J Loeb N Rubin | 5 | 4 |  G Dabrowski R Bopanna | 6 | 2 | [8] | ||||||||||||||||||||
| G Dabrowski R Bopanna | 7 | 6 | G Dabrowski R Bopanna | 5 | 6 | [10] | |||||||||||||||||||||
D Jurak  F Martin | 65 | 3 | 6 | A Hlaváčková Ł Kubot | 7 | 3 | [7] | ||||||||||||||||||||
| 6 | A Hlaváčková Ł Kubot | 77 | 6 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 5 | H-c Chan M Mirnyi | 6 | 6 | ||||||||||||||||||||||||
K Srebotnik  H Kontinen | 4 | 4 | 5 | H-c Chan M Mirnyi | 5 | 62 | |||||||||||||||||||||
 A Parra Santonja M López | 4 | 6 | [6] | WC | N Gibbs D Novikov | 7 | 77 | ||||||||||||||||||||
| WC | N Gibbs D Novikov | 6 | 3 | [10] | WC | N Gibbs D Novikov | 2 | 62 | |||||||||||||||||||
| WC | C McHale R Harrison | 64 | 1 | L Siegemund M Pavić | 6 | 77 | |||||||||||||||||||||
| L Siegemund M Pavić | 77 | 6 | L Siegemund M Pavić | 6 | 6 | ||||||||||||||||||||||
A Spears  S González | 6 | 65 | [10] | A Spears S González | 4 | 2 | |||||||||||||||||||||
| Alt |  O Savchuk  R Lindstedt | 3 | 77 | [4] | L Siegemund M Pavić | 77 | 7 | ||||||||||||||||||||
| 8 | L Hradecká M Matkowski | 5 | 77 | [9] | Y-j Chan N Zimonjić | 65 | 5 | ||||||||||||||||||||
 A Kudryavtseva S Lipsky | 7 | 63 | [11] | A Kudryavtseva S Lipsky | 1 | 2 | |||||||||||||||||||||
| Y-j Chan N Zimonjić | 6 | 64 | [10] | Y-j Chan N Zimonjić | 6 | 6 | |||||||||||||||||||||
| WC | M Oudin M Krueger | 0 | 77 | [4] | Y-j Chan N Zimonjić | 1 | 6 | [13] | |||||||||||||||||||
 T Babos E Butorac | 77 | 6 | 2 | Y Shvedova B Soares | 6 | 3 | [11] | ||||||||||||||||||||
| WC | E Bektas E King | 65 | 1 | T Babos E Butorac | 3 | 5 | |||||||||||||||||||||
 Y Xu  A-u-H Qureshi | 4 | 6 | [8] | 2 | Y Shvedova B Soares | 6 | 7 | ||||||||||||||||||||
| 2 | Y Shvedova B Soares | 6 | 3 | [10] | |||||||||||||||||||||||
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